Clinical trials: Cartilage Defect
Osteochondral Defects of Talus, Gait Analysis
Gait Pattern Analysis After Arthroscopic Treament of Osteochondral Defects of Talus
The study will investigate alterations in post-surgical gait patterns among patients who have undergone all arthroscopic microfracture and biological scaffold implementation surgery for the osteochondral lesions of talus.
- Conditions
- Osteochondral Defects of Talus, Gait Analysis, Microfracture Procedure, Biological Scaffold
- Trial name
- NCT07161128
- Testing
- arthroscopic microfracture and biological scaffold implementation for osteochondral defects of talus
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
Knee Injuries, Cartilage Injury
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
The goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions.
- Conditions
- Knee Injuries, Cartilage Injury, Osteochondral Defect
- Trial name
- NCT06078072
- Testing
- Biomaterials augmented with mesenchymal stem/stromal cells
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Osteochondral Defect
A Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects
The study was designed by the principal investigator, Dr. Andrea Veljkovic, and the St. Paul's Hospital Foot and Ankle Research Group, who will conduct the study.
- Trial name
- NCT03696394
- Testing
- BioCartilage® Micronized Cartilage Matrix
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- St. Paul's Hospital, Canada
Defect of Articular Cartilage
A Study to Evaluate the Safety of Augment™ Bone Graft
Is Augment Bone Graft plus Allograft safe to use for the treatment of osteochondral defects of the knee?
- Trial name
- NCT01290991
- Testing
- Augment Bone Graft
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Nova Scotia Health Authority
Defect of Articular Cartilage, Osteochondritis Dissecans
Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration
The Cartilage Autograft Implantation System (CAIS) is designed as a single surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight or low weight-bearing region.
- Trial name
- CAIS (NCT00881023)
- Testing
- Microfracture, Cartilage Autograft Implantation System
- Where
- 29 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- DePuy Mitek
Degenerative Lesion of Articular Cartilage of Knee
Observational Study on the Treatment of Knee Osteochondral Lesions of Grade III-IV
The purpose of the study is to evaluate prospectively the outcome of treatment interventions of knee osteochondral lesions Outerbridge grade III and IV.
- Trial name
- LOGIC (NCT01554878)
- Testing
- knee surgery
- Where
- 4 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Defect of Articular Cartilage
Smith & Nephew's European Trufit Study
The purpose of this clinical study is to demonstrate the effectiveness and safety of the Trufit CB (Cartilage Bone) implant for the treatment of single, isolated cartilage defects of the knee compared to Microfracture.
- Trial name
- NCT01246635
- Testing
- Trufit CB (Cartilage Bone) Implant, Microfracture if the knee
- Where
- 14 sites in Belgium, Denmark and 6 more
- Volunteers
- 153 people
- Sponsor
- Smith & Nephew, Inc.
Cartilage Disease
Observational Study With NOVOCART® Inject in the Reconstruction of the Hip Joint With Full Thickness Cartilage Defects
Non-interventional study to evaluate safety and efficacy of NOVOCART® Inject in patients with full thickness cartilage defects in the hip.
- Trial name
- HIP-ACTION (NCT02179346)
- Where
- 3 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Tetec AG
Defect of Articular Cartilage
Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee
Subjects will be selected among the investigators' patient population who are already scheduled to receive a marrow stimulating procedure (MSP), with or without the addition of BioCartilage.
- Trial name
- NCT02203071
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Missouri-Columbia
Cartilage Damage, Degenerative Osteoarthritis
UCMSC Transplantation in the Treatment of Cartilage Damage
The purpose of this study is to investigate the efficacy and safety of transplantation of umbilical cord mesenchymal stem cells（UCMSCs） in patient with Knee cartilage damage.
- Trial name
- NCT02776943
- Testing
- umbilical cord mesenchymal stem cells, Hyaluronic acid
- Volunteers
- 20 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Defect of Articular Cartilage
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- FastTRACK (NCT02659215)
- Testing
- Hyalofast, Microfracture
- Where
- 48 sites in United States, Austria and 7 more
- Volunteers
- 200 people
- Sponsor
- Anika Therapeutics, Inc.
Cartilage Defect
A Study of REcycled CartiLage Auto/Allo IMplantation to Treat and Repair Focal Hip Cartilage Defects
The purpose of this research study it to gather information on the safety and side effects of treating cartilage defects with autologous cartilage cells mixed with allogeneic adipose-derived mesenchymal stem cells (AMSCs) in a…
- Trial name
- NCT05553132
- Testing
- Autologous Chondrocytes in their Pericellular Matrix (Chondrons) Coimplanted with Allogeneic Adipose-Derived Mesenchymal Stromal Cells (AMSCs) in a Fibrin Glue Carrier
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Daniel B. F. Saris
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Cartilage Injury, Osteoarthritis
Study to Compare Efficacy and Safety of Cartistem and Microfracture in Patients With Knee Articular Cartilage Injury
The purpose of the study is to assess and compare the safety and efficacy of the allogeneic-unrelated umbilical cord blood-derived mesenchymal stem cell product (Cartistem®) to that of a microfracture treatment in patients with…
- Trial name
- NCT01041001
- Testing
- Cartistem, Microfracture treatment
- Where
- 8 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Medipost Co Ltd.
Hip Arthroscopy, Articular Cartilage Defect
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced…
- Conditions
- Hip Arthroscopy, Articular Cartilage Defect, Microfractures
- Trial name
- REPAIR (NCT05402072)
- Testing
- Autologous matrix-induced chondrogenesis (AMIC)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Chondral Lesion Plus Partial Medial Meniscectomy
Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions
The purpose of this study is to evaluate changes in clinical and imaging outcomes following arthroscopic treatment of a single medial femoral chondral lesion plus partial medial meniscectomy by Radiofrequency-Based debridement or…
- Trial name
- ACT (NCT01803880)
- Testing
- Mechanical Debridement, RF-Based Debridement
- Where
- 7 sites in United States
- Volunteers
- 148 people
- Sponsor
- Smith & Nephew, Inc.
Cartilage Lesion, Osteochondral Lesion
Cone Beam CT (CBCT) Arthrogram of the Ankle in Assessement of Osteochondral or Cartilage Lesions
This study aims to compare weight-bearing Cone Beam CT arthrogram and conventional CT arthrogram in assessement of patients with ankle osteo-chondral or cartilage lesions.
- Trial name
- Arthro-CBCT (NCT05203757)
- Testing
- ArthroCT scan, CBCT
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis, Knee, Osteochondral Defect
The Impact of Covid-19 on Patients Waiting for Knee Surgery
The Covid-19 pandemic has led to the postponement and cancellation of elective orthopaedic surgeries worldwide. These delays to elective procedures combined with ongoing demand have led to increasingly longer waiting list times.
- Conditions
- Osteoarthritis, Knee, Osteochondral Defect, Cartilage Injury, Cartilage Damage
- Trial name
- NCT05124613
- Testing
- Survey
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Manchester
Chondral Defect
The Biomechanical Outcomes of Autologous Chondrocyte Implantation
Injury to the knee can damage the lining of the knee's bones, called cartilage. Cartilage injuries cause pain and limit movement, making activities like walking, playing sports, and working difficult.
- Trial name
- NCT06921889
- Testing
- Autologous Chondrocyte Implantation (ACI)
- Where
- 7 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Manchester
Chondral Defect, Osteochondral Defect
EB-OC for the Treatment of Focal Chondral/Osteochondral Defects in the Knee
EB-OC is a tissue engineered osteochondral tissue graft comprising of a living tissue engineered cartilage layer attaching to a bone scaffold.
- Trial name
- NCT06895889
- Testing
- EB-OC Graft Implantation, Abrasion chondroplasty
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Epibone, Inc.