Clinical trials: Cartilage Defect
Defect of Articular Cartilage, Osteochondral Lesion of Talus
DeNovo NT Ankle LDC Study
The purpose of this post-market clinical study is to collect long-term outcomes for DeNovo NT Graft treatment of articular cartilage lesions in the ankle in a standard clinical setting.
- Conditions
- Defect of Articular Cartilage, Osteochondral Lesion of Talus, Osteochondritis Dissecans
- Trial name
- NCT01347892
- Testing
- DeNovo NT Natural Tissue Graft
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Defect of Articular Cartilage
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- FastTRACK (NCT02659215)
- Testing
- Hyalofast, Microfracture
- Where
- 48 sites in United States, Austria and 7 more
- Volunteers
- 200 people
- Sponsor
- Anika Therapeutics, Inc.
Articular Cartilage Defect
NOVOCART 3D Treatment Following Microfracture Failure
This study is prospective single arm extension study of protocol AAG-G-H-1220. It is open only to participants of AAG-G-H-1220 randomized to the Microfracture treatment group.
- Trial name
- NCT03219307
- Testing
- NOVOCART 3D
- Where
- 5 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Aesculap Biologics, LLC
Chondral Lesion Plus Partial Medial Meniscectomy
Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions
The purpose of this study is to evaluate changes in clinical and imaging outcomes following arthroscopic treatment of a single medial femoral chondral lesion plus partial medial meniscectomy by Radiofrequency-Based debridement or…
- Trial name
- ACT (NCT01803880)
- Testing
- Mechanical Debridement, RF-Based Debridement
- Where
- 7 sites in United States
- Volunteers
- 148 people
- Sponsor
- Smith & Nephew, Inc.
Articular Cartilage Defect Grade III or IV of the Knee
Use of Cell Therapy to Enhance Arthroscopic Knee Cartilage Surgery
The purpose of this study is to assess the potential benefit of enhancing knee surgery for cartilage injury using some of the patient's own cells, taken from fat tissue, that may be able to help cartilage to regenerate.
- Trial name
- NCT01799876
- Testing
- Autologous Cell, Standard microfracture arthroscopic surgery
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Fondren Orthopedic Group L.L.P.
Cartilage Damage, Degenerative Osteoarthritis
UCMSC Transplantation in the Treatment of Cartilage Damage
The purpose of this study is to investigate the efficacy and safety of transplantation of umbilical cord mesenchymal stem cells（UCMSCs） in patient with Knee cartilage damage.
- Trial name
- NCT02776943
- Testing
- umbilical cord mesenchymal stem cells, Hyaluronic acid
- Volunteers
- 20 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Articular Cartilage Defect, Articular Cartilage Degeneration
Phase 2 Clinical Trial of CartiLife® in the United States
To evaluate the safety and efficacy of implanting pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject with articular cartilage defects of the…
- Trial name
- NCT04744402
- Testing
- Autologous Chondrocyte Implantation (CartiLife®)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Biosolution Co., Ltd.
Cartilage Diseases
Non-Interventional Study to Evaluate Safety and Efficacy of NOVOCART 3D in Patients With Cartilage Defects
Non-interventional study to evaluate safety and efficacy of NOVOCART 3D in adult and adolescent patients with full thickness cartilage defects after the treatment with NOVOCART 3D.
- Trial name
- NISANIK (NCT02348697)
- Testing
- NOVOCART 3D
- Where
- 9 sites in Germany
- Volunteers
- 81 people
- Sponsor
- Tetec AG
Osteochondral Defects of Talus, Gait Analysis
Gait Pattern Analysis After Arthroscopic Treament of Osteochondral Defects of Talus
The study will investigate alterations in post-surgical gait patterns among patients who have undergone all arthroscopic microfracture and biological scaffold implementation surgery for the osteochondral lesions of talus.
- Conditions
- Osteochondral Defects of Talus, Gait Analysis, Microfracture Procedure, Biological Scaffold
- Trial name
- NCT07161128
- Testing
- arthroscopic microfracture and biological scaffold implementation for osteochondral defects of talus
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
Articular Cartilage Defect, Chondral Defect
Introduction of ACI for Cartilage Repair
This study was aimed to evaluate effectiveness and safety of autologous chondrocyte suspension for treatment of knee articular cartilage defects.
- Conditions
- Articular Cartilage Defect, Chondral Defect, Osteochondritis
- Trial name
- NCT04296487
- Testing
- autologous chondrocytes
- Where
- Switzerland
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cartilage Diseases, Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for articular cartilage defect of knee.
- Trial name
- NCT02291926
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Cartilage Defect, Elbow Injury
A Study of Collagen Scaffold for the Repair of Elbow Cartilage Injury
The goal of this clinical trial is to test whether adding a collagen protein scaffold can improve cartilage repair in elbow joint injuries, compared to standard surgery alone.
- Trial name
- NCT07149896
- Testing
- Collagen Scaffold (Colla-Plug), microfracture
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Jishuitan Hospital
Articular Cartilage Defects in the Knee Joint
Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects
Multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (GelrinC). This study compares the efficacy and safety of GelrinC to a historical control arm (microfracture) in the treatment…
- Trial name
- SAGE (NCT03262909)
- Testing
- GelrinC, Microfracture historical control arm
- Where
- 13 sites in United States
- Volunteers
- 181 people
- Sponsor
- Regentis Biomaterials
Articular Cartilage Defect, Articular Cartilage Degeneration
Phase 3 Clinical Trial of CartiLife® in Korea
To evaluate the safety and efficacy of pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject implanted into articular cartilage defects of the…
- Trial name
- NCT05051332
- Testing
- Autologous Chondrocyte Implantation (CartiLife®), Microfracture Surgery
- Where
- 18 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Biosolution Co., Ltd.
Articular Cartilage Defect
Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
The objective of this trial is to demonstrate superior efficacy and safety of MACI compared with arthroscopic microfracture in the treatment of patients (aged 18 to 55 years) with symptomatic articular cartilage defects of the…
- Trial name
- SUMMIT (NCT00719576)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 20 sites in Czechia, France and 5 more
- Volunteers
- 144 people
- Sponsor
- Vericel Corporation
Osteoarthritis, Knee, Chondral Defect
Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage Treated in the Arthroscopic Technique With the Use of:Autogenous Transplantation of Fragmented Adipose Tissue,PRP GF,Mesenchymal Cells,Hyaluronic Acid-low Molecular Weight and Cross-linked
The main objective of the research project is to evaluate the results of the treatment of chondromalacia of the cartilage in the knee joint with the use of: autogenous transplantation of fragmented adipose tissue taken from the…
- Conditions
- Osteoarthritis, Knee, Chondral Defect, Chondromalacia, Left Knee, Chondromalacia, Right Knee
- Trial name
- NCT07110402
- Testing
- Autogenous transplant of fragmented adipose tissue taken from abdominal integuments, PRP GF (platelet-rich plasma with growth factors), Mesenchymal cells centrifuged from bone marrow cells taken from the iliac crest
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- eMKa MED Medical Center
Cartilage Disease
Observational Study With NOVOCART® Inject in the Reconstruction of the Hip Joint With Full Thickness Cartilage Defects
Non-interventional study to evaluate safety and efficacy of NOVOCART® Inject in patients with full thickness cartilage defects in the hip.
- Trial name
- HIP-ACTION (NCT02179346)
- Where
- 3 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Tetec AG
Defect of Articular Cartilage
Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects
The purpose of this study is to: Compare the treatment efficacy of autologous mesenchymal stem cells (Mesenchymal Stem Cells) versus chondrocytes implanted in a commercial available scaffold in a human clinical trial.
- Trial name
- NCT00885729
- Testing
- stem cells, Chondrocytes, Rehabilitation program
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Articular Cartilage Defect
A Study to Compare Two Techniques for Articular Cartilage Repair:ACIC Vs. MCIC
Study Title: A study to compare two articular cartilage repair techniques in the knee joint: Autologous Collagen Induced Chondrogenesis (ACIC) Vs. Mesenchymal Cell Induced Chondrogenesis (MCIC).
- Trial name
- NCT01984450
- Testing
- ACIC, MCIC, implant with a collagen + fibrin gel mixture
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Shetty-Kim Research Foundation
Cartilage Disease
Non-interventional Study With NOVOCART® 3D for the Treatment of Cartilage Defects of the Knee in Pediatric Patients
Prospective, multicenter, single-arm non-interventional study to evaluate the efficacy, safety and health economics of NOVOCART 3D in the Treatment fo cartilage defects of the knee in pediatric patients wieh closed epiphyseal…
- Trial name
- JUNOVO (NCT04186208)
- Testing
- NOVOCART 3D
- Where
- 6 sites in Germany
- Volunteers
- 42 people
- Sponsor
- Tetec AG