Clinical trials: Cartilage Diseases
Obesity, Osteoarthritis
Reducing Obesity and Cartilage Compression in Knees
OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for the development and…
- Conditions
- Obesity, Osteoarthritis, Knee Osteoarthritis
- Trial name
- ROCCK (NCT04730557)
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Cartilage Destruction
Оptical Spectroscopy in the Diagnosis of Intra-articular Injuries
Intra-articular joint injuries are the most common and prognostically unfavorable in case of untimely or erroneous diagnosis, which leads to a significant violation of the quality of life and activity of patients.
- Trial name
- NCT05454605
- Where
- Russia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Microtia, Congenital, Microtia
Rib Microtia and the Erector Spinae Plane (ESP) Block
The erector spinae plane block is a novel regional anesthetic technique that allows for analgesia of the thorax and abdomen with a peripheral nerve block.
- Conditions
- Microtia, Congenital, Microtia, Anesthesia, Local, Anesthesia
- Trial name
- NCT03729427
- Testing
- Erector Spinae Plane Block
- Where
- United States
- Sponsor
- Stanford University
Foreign-Body Reaction, Inflammation
IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee.
Articular cartilage defects in the knee have a poor intrinsic healing capacity and may lead to functional disability and osteoarthritis.
- Conditions
- Foreign-Body Reaction, Inflammation, Effusion (L) Knee, Knee Pain Swelling
- Trial name
- IMPACT (NCT02037204)
- Testing
- Cartilage repair surgery
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- UMC Utrecht
Slipping Rib Syndrome
Slipping Rib Syndrome: A Clinical Entity to Consider in Chest Pain
Slipping rib syndrome consists on false or floating ribs hypermobility, whose can force the ribs to come in contact with each other. The authors reported a fourteen case series presenting a slipping rib syndrome.
- Trial name
- NCT04226638
- Testing
- Dynamic ultrasound
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- AMS Centro Medico del Ejercicio
Articular Cartilage Disorder
Investigation of a Customized Femoral Resurfacing Implant
The purpose is to assess the safety profile and performance of a femoral resurfacing implant for localized chondral lesions.
- Trial name
- Knee100 (NCT01690689)
- Testing
- Implant surgery
- Where
- 3 sites in Sweden
- Volunteers
- 10 people
- Sponsor
- Episurf Medical Inc.
Chondromalacia Patellae
Neuroprolotherapy With Physical Therapy for Treatment of Patellar Chondromalacia
Patellar chondromalacia is the degeneration of articular cartilage located on the posterior face of the patella and may suggest the onset of an osteoarthrosis.
- Trial name
- NCT03515720
- Testing
- Prolotherapy
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto Mexicano del Seguro Social
Hemiplegia
The Relationship Of Ultrasonographic Measurements With Sarcopenia in Stroke
introduction:The aim of this study was to show the relationship of distal femoral cartilage and quadriceps thicknesses with functional status and presence of sarcopenia in ambulatory stroke patients with voluntary movement.
- Trial name
- NCT06254573
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kayseri City Hospital
Microtia, Outcome Assessment
Safety and Efficacy of Connecting the Residual Ear to the Cartilage Scaffold in First- vs. Second-Stage Surgery
Eligible patients will be admitted from the outpatient clinic to complete the relevant examinations after admission（Preoperative routine examination and chest CT）.
- Conditions
- Microtia, Outcome Assessment, RCT, Surgery Related Complications Rate
- Trial name
- NCT06763991
- Testing
- Two-stage connection, One-stage connection
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sichuan Provincial People's Hospital
Knee Osteoarthritis
The Effect of Corrective Osteotomy on in Vivo Cartilage Mechanobiology in Patients With Knee Osteoarthritis
Our overall hypothesis is that a sudden ambulatory load reduction (caused by corrective osteotomy) leads to changes in cartilage biology that delay or reverse osteoarthritic processes determining the clinical outcome and…
- Trial name
- Osteotomy (NCT02622204)
- Testing
- Corrective osteotomy
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarthritis
Effects of Synvisc on Cartilage in Knee Osteoarthritis (OA)
Hylan G-F 20 (Synvisc) is an FDA-approved hyaluronate derivative used to treat knee osteoarthritis (OA). Animal studies have shown that Synvisc can have favorable effects on cartilage when injected into joints.
- Trial name
- NCT00949494
- Testing
- Synvisc
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Endeavor Health
Osteoarthritis, Knee, Articular Cartilage Defects of the Knee
Subchondral Drilling Diameter During CARTISTEM Implantation for Knee Cartilage Defects
This prospective, randomized study at Severance Hospital compares two subchondral drilling techniques during CARTISTEM implantation for symptomatic medial-compartment knee articular cartilage defects.
- Trial name
- NCT07881445
- Testing
- 2-mm subchondral drilling, Sequential 4-mm and 2-mm subchondral drilling
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Hemophilia A
Cartilage Biomarkers and HEAD-US Score in Severe Hemophilia A Patients Receiving FVIII Prophylaxis
Patients with severe hemophilia A often develop joint complication requiring careful monitoring. This study aimed to compare the effectiveness of standard low dose weight-based FVIII concentrates (CFCs) prophylaxis with…
- Trial name
- HEADUS_SHA8 (NCT06816953)
- Testing
- HEAD-US, Urinary carboxy-terminal cross linked telopeptide of type II collagen, Inflammatory markers
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Chulalongkorn University
Joint Disease
Extracellular Vesicles in Fibrin Gel for Cartilage Repair
This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth…
- Trial name
- GelVex (NCT06713902)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteoarthritis, Knee
Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial
Phase I/II randomized, double-blind, placebo-controlled clinical trial to test the safety and efficacy of Fisetin for treating mild to moderate osteoarthritis
- Trial name
- NCT04210986
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Steadman Philippon Research Institute
Chondromalacia Patellae
Intermedius Genicular Nerve in the Treatment of Patients With Chondromalacia Patella
Radiofrequency application is a treatment method that temporarily prevents the transmission of pain in the nerve where the application is made through the heat emitted by radio waves.Partial inhibition of the functions of the…
- Trial name
- NCT05096520
- Testing
- radiofrequency, control, 2% lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Articular Cartilage Disorder of Knee
Radiofrequency-Based Debridement vs. Mechanical Debridement for the Treatment of Articular Cartilage Lesions
The purpose of this study is to evaluate the changes in clinical and imaging outcomes following arthroscopic treatment of chondral lesion(s) by Radiofrequency-Based debridement or Mechanical Debridement in subjects 18-50 years of…
- Trial name
- NCT03678948
- Testing
- Radiofrequency-Based Debridement, Mechanical Debridement
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Christopher Kaeding
Chondral Defect, Articular Cartilage Defect
A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle
The objective of this study is to demonstrate the superiority of MACI (autologous cultured chondrocytes on porcine collagen membrane) versus Bone Marrow Stimulation in the treatment of patients aged 17 to 65 years with…
- Trial name
- MASCOT (NCT06915233)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation
- Where
- 9 sites in United States
- Volunteers
- 309 people
- Sponsor
- Vericel Corporation
Hip Dysplasia
Periacetabular Osteotomy With Versus Without Adjunctive Hip Arthroscopy
Although evidence is amassing regarding the role of intra-articular pathology in the surgical management of adolescents and adults with hip dysplasia, the optimal method of detection and especially management of this pathology…
- Trial name
- PRSPAO (NCT02790749)
- Testing
- Adjunctive hip arthroscopy to accompany PAO, PAO without adjunctive hip arthroscopy
- Volunteers
- 44 people
- Sponsor
- Sharp HealthCare
Knee Osteoarthritis
Evaluation of Femoral Cartilage Thickness After Treadmill and Tartan Track Walking
The aim of this study is to measure and compare the femoral cartilage deformation after walking on the treadmill and tartan floor in patients with knee osteoarthritis (OA) and healthy volunteers.
- Trial name
- NCT05316792
- Testing
- walking
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pamukkale University