Clinical trials: Cavities
Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders
Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer Triage
This research study evaluates an experimental, point-of-care tool that combines Deep Ultraviolet (DUV) light imaging with Artificial Intelligence (AI) to rapidly screen for oral cancer and pre-cancer (dysplasia).
- Conditions
- Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Cancer
- Trial name
- DEEP UV-M (NCT07842211)
- Testing
- Deep UV-M and AI Cytology Triage
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Anh Le
Anal Carcinoma, Cervical Carcinoma
Extended Follow Up of Young Women in Costa Rica Who Received Vaccine for Human Papillomavirus Types 16 and 18 and Unvaccinated Controls
This research trial studies extended follow up of young women in Costa Rica who received vaccine for human papillomavirus types 16 and 18 and unvaccinated controls.
- Conditions
- Anal Carcinoma, Cervical Carcinoma, Human Papillomavirus Infection, Human Papillomavirus-Related Cervical Carcinoma
- Trial name
- NCT00867464
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Long-term Follow-up
- Where
- Costa Rica
- Volunteers
- 8,670 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Glioma
Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer
The objective of this study is to assess two novel positron emission tomography (PET) radiotracers, [64Cu]CM500 and [68Ga]CM500, for Positron Emission Tomography-Magnetic Resonance Imaging (PET-MR) and Positron Emission…
- Conditions
- Bladder Cancer, Glioma, Glioblastoma (GBM), Breast Cancer
- Trial name
- NCT07781852
- Testing
- [64Cu]CM500, [68Ga]CM500, PET/MR
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lumina Pharmaceuticals Inc
Nasal Cavity, CBCT Segmentation
Serrated Inferior Turbinate Variation and Sinonasal Findings on CBCT
regulate nasal airflow, humidify and filter inspired air. Serrated inferior turbinate is a rare anatomical variation characterized by an irregular, serrated appearance of the inferior turbinate bone.
- Trial name
- NCT07739927
- Testing
- No intervention (retrospective CBCT imaging analysis)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Alcohol-Related Carcinoma, Fanconi Anemia
Role of Acetaldehyde in the Development of Oral Cancer
This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points.
- Conditions
- Alcohol-Related Carcinoma, Fanconi Anemia, Oral Cavity Carcinoma
- Trial name
- NCT05973656
- Testing
- Alcohol, Biospecimen Collection, Breath Test
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
The Importance of Mucosal Screening in the Prevention of Oral Cancer.
Patients attending the Department of Oral Mucosal and Periodontal Diseases at the University Dental Center of the Medical University of Warsaw who provide written informed consent will be invited to participate in the study.
- Conditions
- OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Potentially Malignant Lesions, Leukoplakia Oral
- Trial name
- NCT07682883
- Testing
- Fluorescent oral examination (FOE), Conventional oral examination
- Where
- Poland
- Volunteers
- 1,383 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Dental Cavity
Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries
The primary objective of this study is to estimate the distribution of pathogenic species and genotypes of bacterial diversity in 7 stages ICDAS (International Caries Detection and Assessment System) corresponding to the severity…
- Trial name
- Caries Species (NCT02056262)
- Testing
- Dental cavity evaluation, Saliva sampling, Plaque sampling
- Where
- 3 sites in France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cavities of Teeth
The Effects of Bundling Dental and Medical Appointments and Price on Uptake of Preventive Dental Care
This study evaluates the effectiveness of behavioral messages sent via WhatsApp in encouraging patients to schedule preventive dental check-ups.
- Trial name
- NCT07121673
- Testing
- Dental appointment message, Dental appointment message with price discount, Bundling frame
- Where
- Chile
- Volunteers
- 306,524 people, healthy volunteers welcome
- Sponsor
- University of Chile
Oral Cancer, Chatbot
Enhancing Oral Cancer Awareness
To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention
- Conditions
- Oral Cancer, Chatbot, Patient Education, Prevention
- Trial name
- NCT06682494
- Testing
- Traditional Education, AI-powered Chatbox
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cavities of Teeth
Esthetics of Dental Composite and Adhesive System
To compare a newly developed filling composite to a current filling composite system. Two restorations will be placed in each subject, one using system A and one using system B.
- Trial name
- NCT03716349
- Testing
- Pulp vitality testing, Photos, local and/or topical anesthetic
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Erica Teixeira
Nasal Cavity and Paranasal Sinus Cancer
Evaluation of Endoscopic Management of Sinonasal Tumors In Difficult Anatomical Locations
Research outcome measures: 1. Primary (main): To Evaluate the Gross Total Resection Rate Using Endoscopic Approach for Lesions Extended To Anatomically Challenging Areas 2. Secondary (subsidiary): 1.
- Trial name
- NCT07512466
- Testing
- endoscopic approch
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assiut University
Parenting, Cavity, Dental
Brief Interventions to Improve Behavior Outcomes and Prevent Cavities
The investigators will study brief educational interventions designed to address childhood behavior problems and prevent cavities.
- Conditions
- Parenting, Cavity, Dental, Child Behavior
- Trial name
- NCT06588725
- Testing
- Play Nicely, Cavity Prevention Handout
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Demineralization, Remineralization
Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model
Clinical study to evaluate the anti-cavity effectiveness of three dentrifices using an intra-oral enamel Demineralization and Remineralization In-Situ Model.
- Conditions
- Demineralization, Remineralization, Dental Cavity, Enamel Lesions
- Trial name
- NCT07134231
- Testing
- Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Enamel Lesions, Demineralization, Tooth
Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model
Clinical study to evaluate the anti-cavity efficacy of three dentifrices using an intra-oral enamel Demineralization - Remineralization In-Situ Model. This is a Phase III, single-center, triple-blind with a crossover design.
- Conditions
- Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity
- Trial name
- REPAIR (NCT06732518)
- Testing
- Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Comparison of Bulk Fill vs HVGIC in Class II Cavities
Clinical Performance of HVGIC vs Bulk Fill Composite in Class II Cavities of Posterior Teeth: A 12-Month RCT
Study Title: Clinical Performance of Highly Viscous Glass Ionomer versus Bulk Fill Resin Composite Restorative Materials in Moderate Class II Cavities of Permanent Posterior Teeth: A 12-Month Randomized Clinical Study Study…
- Trial name
- NCT07067164
- Testing
- Bulk fill resin composite restorative material
- Where
- Egypt
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Papillomavirus Vaccines, Human Immunodeficiency Virus
Immunogenicity of Gardasil-9 HPV Vaccine in People Living With HIV
The primary objective of this study is to determine the magnitude and breadth of the serum antibody response to the nonavalent HPV vaccine (Gardasil-9) in adults with well-controlled HIV infection.
- Conditions
- Papillomavirus Vaccines, Human Immunodeficiency Virus, Papillomavirus Infection, Serology
- Trial name
- AGO-Gard (NCT05266898)
- Testing
- Human papillomavirus 9-valent vaccine, recombinant, human papillomavirus vaccine, recombinant
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Dental Cavity, Caries,Dental
Effectiveness of a Nutritional Counseling Tool in Reducing the Amount and Frequency of Sugar Intake
The purpose of the study is to assess the effectiveness of nutritional counselling on added sugar consumption, frequency of snacking and caries experiences expressed as Decayed, Missing, and Filled Teeth score (DMFT).
- Trial name
- NCT06673342
- Testing
- Nutritional Counseling
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Proximal Cavities of Posterior Teeth
Clinical Performance of Injectable Universal Flowable Composite in Proximal Cavities of Posterior Teeth.
The aim of the study is to evaluate the clinical performance of injectable universal flowable composite vs conventional resin composite restorations in proximal cavities of posterior teeth.
- Trial name
- NCT05263089
- Testing
- PALFIQUE® Universal Flow; Tokuyama, Tokyo, Japan (super low flowability), ESTELITE® Alpha; Tokuyama, Tokyo, Japan
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oropharyngeal Cancers, Biomarker in Early Diagnosis
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
The goal of this observational study is to evaluate whether the active-matrix metalloproteinase-8 (aMMP-8) mouth-rinse test can help detect oral and oropharyngeal cancers.
- Conditions
- Oropharyngeal Cancers, Biomarker in Early Diagnosis, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Periodontal Diseases
- Trial name
- NCT06701058
- Where
- Finland
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital