Clinical trials: Cell Function
Stem Cell Transplantation
Physical Impairments in Allogeneic-HSCT
Pulmonary functions, exercise capacity and muscle strength deteriorate in survived hematopoietic stem cell transplantation (HSCT) recipients due to toxic effects of chemotherapy, radiotherapy, conditioning regimens and/or…
- Trial name
- NCT03448627
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Gazi University
Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication
Red Blood Cell Transfusion in ECMO - A Feasibility Trial
Extracorporeal Membrane Oxygenation (ECMO) is an invasive and resource intense treatment used to support critically ill patients who have suffered severe cardiac arrest, cardiac failure or respiratory failure (including severe…
- Conditions
- Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication, Disability Physical, Cognitive Ability, General
- Trial name
- ROSETTA (NCT05814094)
- Testing
- Red Blood Cell Transfusion
- Where
- 2 sites in Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Lymphoblastic Leukemia
Endothelial Function, Arterial Stiffness and Components
Specific Aim: Compare the endothelial function, arterial stiffness and components of metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy sibling controls.
- Trial name
- NCT01439217
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cervical Cancer, Breast Cancer
Cytokine Regulation of Natural Killer Receptors in Inhibiting Activated T Cell Function
In this study proposal, the investigators will extend their previous studies and examine the kinetic cytotoxic activity with concordant expression of inhibitory natural killer (NK) receptors (iNKR) on activated T cells.
- Conditions
- Cervical Cancer, Breast Cancer, Endometrial Cancer, Cancer
- Trial name
- NCT00173290
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Psoriasis
Effect of Chronic Inflammation on Myocardial Perfusion and Function
Background: Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF.
- Trial name
- NCT04870827
- Testing
- 13N Amonia
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
the Diabetic Process
Deacylated Ghrelin and Beta Cell Function
Use of human unacylated ghrelin (UAG, also called des-octanoyl ghrelin) to study physiology in healthy subjects. The proposed research is an investigator-initiated study funded by the National Institutes of Health designed to…
- Trial name
- UAG (NCT01531283)
- Testing
- unacylated ghrelin, acyl ghrelin, combined acyl and desacyl ghrelin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- David Dalessio
Graves Disease
Characteristics of Islet β-cell Functions in Chinese Patients With Graves' Disease
Patients with GD often present with glucose dysregulation, which, according to most studies, is associated with islet β-cell dysfunctions, enhanced gluconeogenesis and insulin resistance (IR).
- Trial name
- NCT02376088
- Testing
- Methimazole
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Weikai Hou
High Grade Gliomas, Hypoxia Brain
Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response
High-grade gliomas (HGGs) are the most common type of brain cancer in adults. Life expectancy for patients with HGGs is low. Radiotherapy aims to cure the tumour, but this is hard because HGGs are resistant to treatment.
- Conditions
- High Grade Gliomas, Hypoxia Brain, Glioblastoma (GBM), Brain Neoplasms, Adult
- Trial name
- BRIGHTER (NCT07670455)
- Testing
- Oxygen-Enhanced MRI (OE-MRI)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Type 1 Diabetes
Combination Therapy With Sitagliptin and Lansoprazole to Restore Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes
Sanford Research/USD proposes to study the combination therapy of oral administration of sitagliptin and lansoprazole versus placebo for the preservation of pancreatic beta cells still present in patients with recent-onset…
- Trial name
- REPAIR-T1D (NCT01155284)
- Testing
- Sitagliptin and Lansoprazole
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Hypertriglyceridemia, Glucose Intolerance
Impact of Plasma Lipids on β Cell Function and Insulin Sensitivity
The investigators aim to evaluate whether and to what extent glucose tolerance, beta cell function, insulin clearance, and glucose metabolic fluxes change in response to an acute increase in plasma triglycerides during lipid…
- Trial name
- NCT05181514
- Testing
- 20% Intralipid, Normal Saline
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Skeletal Muscle Hypertrophy
Effects of a Multi-ingredient Supplement Study: a Randomized Controlled Trial in Men and Women
Resistance exercise training is a known stimulant for muscle protein synthesis (MPS) to occur, however the consumption of protein is also necessary to induce a shift towards a positive net protein balance.
- Trial name
- SRCT (NCT03525197)
- Testing
- Whey protein-based supplement, Collagen protein-based supplement
- Where
- 2 sites in Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- McMaster University
Shock, Septic
Mitochondrial Function of Immune Cells in Sepsis
Introduction: Evidence suggests that sepsis and septic shock severely impair mitochondria and that the resulting mitochondrial dysfunction is related to the severity and outcome of the resulting organ dysfunction.
- Trial name
- MitoSepsis (NCT01600989)
- Testing
- blood sampling
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Diseases
Red Blood Cell ATP Release and Vascular Function in Humans
Previous work demonstrates that the red blood cells of older adults do not release a potent vasodilator (ATP) as well as the red blood cells of younger adults.
- Trial name
- NCT03404843
- Testing
- Fasudil Hydrochloride, Saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Diabetes Mellitus, Healthy
Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus
Type 1 diabetes mellitus is an autoimmune disease in which the body's immune cells attack the insulin-producing cells of the pancreas.
- Trial name
- NCT00001985
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Zinc Deficiency, Inflammation
Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc
The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater…
- Conditions
- Zinc Deficiency, Inflammation, Metabolic Diseases, Vascular Diseases
- Trial name
- NCT05236374
- Testing
- Beef protein
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Arteriosclerosis, Stress, Psychological
The Effect of Beta-Blockers and Aspirin on Hemostasis and Endothelial Function After Acute Mental Stress
This randomized double-blinded controlled trial uses a factorial design to investigate whether application of beta-blockers (inderal 80 mg) or aspirin (100 mg) or a combination thereof has an effect on the activation of the…
- Trial name
- NCT00174902
- Testing
- inderal (drug), acetylsalicylic acid (drug)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
PreDiabetes
A Trial to Assess Diets Containing Beef vs. Poultry on Pancreatic Beta-Cell Function
The objective of this study is to assess and compare the effects of usual diets containing lean beef vs. lean poultry on pancreatic beta-cell responses in men and women with prediabetes.
- Trial name
- NCT05456477
- Testing
- Beef, Poultry
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
COPD, Smoking
COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function
Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD), the 4th cause of mortality in the US. Central to COPD pathogenesis is "ciliopathy", dysfunction of the airway ciliated cells that mediate…
- Trial name
- NCT01974154
- Testing
- Cohort I, Cohort II
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sickle Cell Disease
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia
MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease.
- Trial name
- MitoQ (NCT04109820)
- Testing
- MitoQ
- Where
- 5 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh