Clinical trials: Cell Function, open to volunteers
Bronchiolitis Obliterans Syndrome
Novel Pulmonary Function Measures for Diagnosis of Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem-Cell Transplantation in Children
In this study, we will study 129Xe-MRI and LCI as tools for diagnosis of BOS in pediatric patients who have received Hematopoietic Stem Cell Transplantation (HSCT) and have been identified as eligible for this study.
- Trial name
- NCT04391335
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- The Hospital for Sick Children
Overweight (BMI > 25), Males and Females
IMPACT: Immune and Musculoskeletal Physiological Adaptations to Combined Exercise Training & Nutrition
The purpose of this study is to determine whether 12 weeks of exercise training combined with dairy consumption influences inflammation and immune responses in adults with overweight, compared to exercise training alone.
- Trial name
- NCT07513987
- Testing
- Milk, Greek Yogurt, Exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- York University
Diabetes Mellitus, Type 1
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.
- Trial name
- NCT07222332
- Testing
- Baricitinib
- Where
- 131 sites in United States, Australia and 18 more
- Volunteers
- 300 people
- Sponsor
- Eli Lilly and Company
Immune System, Stress
Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals
The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.
- Conditions
- Immune System, Stress, Chronic Stress, Cardiovascular Health
- Trial name
- NCT07735221
- Testing
- Peanuts, roasted, salted with skins, Isocaloric food
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Kidney Tumors, CKD
Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery
This clinical trial is an open-label, randomized controlled study designed to evaluate the efficacyand safety of salt substitutes in protecting renal function after kidney tumor surgery, aiming toprovide dietary renal protection…
- Conditions
- Kidney Tumors, CKD, Salt Substitute, Nephrectomy
- Trial name
- NCT07062952
- Testing
- Salt substitute
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jinling Hospital, China
Diabetes, Pre-diabetes
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
The objective of this clinical trial is to explore whether L-arginine supplementation with 3.32g/day may enhance antioxidant defenses in overweight and obese patients with pre-diabetes and metabolic syndrome, possibly providing…
- Conditions
- Diabetes, Pre-diabetes, Metabolic Syndrome
- Trial name
- L-BIOARG (NCT06686069)
- Testing
- bioarginina zero
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Federico II University
Multiple Myeloma
Lymphodepleting Total Body Irradiation (TBI) Plus Cyclophosphamide Prior to Ciltacabtagene Autoleucel (Carvykti; Cilta-cel) for Multiple Myeloma (MM) Patients With Impaired Renal Function
Treatment for relapsed/refractory multiple myeloma continues to evolve with the approval of highly effective anti-BCMA CAR T therapies in recent years.
- Trial name
- NCT06623630
- Testing
- Cyclophosphamide, Ciltacabtagene Autoleucel, Total body irradiation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
LAL
A Precision Medicine Trial for Patients With Relapsed or Refractory T Cell ALL
To evaluate the benefit of a precision medicine based strategy (targeted therapeutic options (TTOs)) for patients with relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) (in terms of composite remission).
- Trial name
- ALL-TARGET (NCT07522801)
- Testing
- Venetoclax + Tofacitinib, Venetoclax+ Everoliumus +Enrylaze, Venetoclax + 5 Azacitidine
- Where
- 69 sites in Czechia, France and 4 more
- Volunteers
- 93 people
- Sponsor
- Philippe ROUSSELOT
Conjunctivitis, Allergic
Treg Effector Function and Th2/Treg Ratio in Allergic Conjunctivitis: Effect of Desensitization Therapy
This study aims to evaluate the effector function and expression of TIGIT and PD-1 on Tregs, as well as the Th2/Treg ratio, in patients with allergic conjunctivitis with and without desensitization therapy, compared to healthy…
- Trial name
- INMUNOREG (NCT07171307)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Non-Small Cell Lung Cancer
Single-Center Intelligent Pulmonary Rehabilitation After Lung Cancer Surgery
This study will compare an intelligent pulmonary function exercise device with usual care and natural recovery in patients recovering from lung cancer surgery.
- Trial name
- NCT07631533
- Testing
- Intelligent Pulmonary Function Exercise Device, Usual Care and Natural Recovery
- Volunteers
- 200 people
- Sponsor
- Jianxing He
End Stage Kidney Disease, Immunological Tolerance
Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants
The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function…
- Conditions
- End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- NCT05525507
- Testing
- Conditioning and Stem cell infusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Paragangliomas
Comparison of an Initial Active Follow-up and Therapeutic Care on Functional Outcome and Quality of Life in Patients With Head and Neck Paragangliomas
Head and neck paragangliomas (HNPGs) are predominantly non-secreting, benign and slow-growing tumors. Although most patients remain asymptomatic, up to 30% develop symptoms related to local tumor growth and fewer than 5-10%…
- Trial name
- PRONO-PARAG-N (NCT07784595)
- Testing
- Active follow-up, Surgery, Radiation
- Where
- 8 sites in France
- Volunteers
- 122 people
- Sponsor
- Hospices Civils de Lyon
Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia
Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia
This clinical trial evaluates the effects of hemoglobin threshold-specific packed red blood cell (PRBC) transfusions on quality of life and functional outcomes in patients who have undergone chemotherapy or an allogeneic…
- Conditions
- Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Myeloid Neoplasm
- Trial name
- NCT06710418
- Testing
- Activity Tracking, Biospecimen Collection, Cognitive Assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Type 2 Diabetes
Novel Chinese Medicine Formula for Diabetes
Diabetes is a leading cause of heart disease, stroke, kidney failure, cancer and premature death. One in 10 adults are affected by diabetes.
- Trial name
- NCT06978023
- Testing
- JM-LD, JM-HD
- Where
- Hong Kong
- Volunteers
- 162 people
- Sponsor
- Chinese University of Hong Kong
Splenectomy
Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response…
- Trial name
- SPLEENVIVO (NCT06418256)
- Testing
- Spleen, blood and plasma collection
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Female Infertility Due to Diminished Ovarian Reserve
Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age
Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment.
- Trial name
- NCT07685431
- Testing
- Alpha-Lipoic Acid (ALA)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Thyroid Neoplasms, Carcinoma, Papillary
Hybrid Endoscopic Hemithyroidectomy and Targeted Ablation for Bilateral Papillary Thyroid Carcinoma
This study evaluates a thyroid-function-preserving alternative to routine total thyroidectomy for bilateral papillary thyroid carcinoma (PTC).
- Trial name
- NCT07033572
- Testing
- Endoscopic Hemithyroidectomy with Central-Neck Dissection, Ultrasound-Guided Radiofrequency Ablation of Contralateral Nodule
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Sepsis, Critical Illness
Metabolic and Functional Study of γδ T Cells in Critically Ill Patients
This prospective observational cohort study investigates the subset-specific metabolic adaptation and functional remodeling of cytotoxic γδ T cells in critically ill patients with and without sepsis.
- Conditions
- Sepsis, Critical Illness, Immunosuppression, MODS
- Trial name
- NCT07680816
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Latent Autoimmune Diabetes in Adults (LADA)
Effects of Cofrogliptin on Beta-Cell Function in LADA Patients
This single-center, randomized, open-label, controlled study aims to evaluate the effect of cofrogliptin on pancreatic β-cell function in adults with latent autoimmune diabetes in adults (LADA).
- Trial name
- NCT07460336
- Testing
- Cofrogliptin, Vitamin D3, Metformin
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Second Xiangya Hospital of Central South University
Craniometaphyseal Dysplasia
Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD)
CMD can be inherited in an autosomal dominant or recessive trait. CMD may also be caused by de novo mutations. The goal of this study is to identify genes and regulatory elements on chromosomes that are the cause for CMD.
- Trial name
- CMD (NCT01630460)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- UConn Health