Clinical trials: Cell Proliferation
Benign Breast Disease
Nuclear Morphology of Breast Cells in Ductal Lavage
Breast nipple aspirate fluids (NAF) are useful for non-invasive monitoring of the breast. NAF has been shown to exhibit large inter-individual differences in lipid peroxidation.
- Trial name
- NCT00259597
- Testing
- breast ductal lavage
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Acute Humoral Rejections, Chronic Humoral Rejections
Effects of Thymoglobulin on Human B Cells
This study is being done to better understand how immunosuppressive medications (anti-rejection medications that may or may not be approved by the Food and Drug Administration (FDA)) affect the alloimmune response (how a person's…
- Conditions
- Acute Humoral Rejections, Chronic Humoral Rejections, Transplant
- Trial name
- NCT02137876
- Testing
- Blood Draws
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Osteosarcoma
Extracorporeal Shock Wave Therapy on Osteoblast-Like Cells In- Vitro Study
The idea of treating different deformities or diseases in the maxillofacial region with Extracorporeal Shockwave Therapy (ESWT) has recently become popular.
- Trial name
- ESWT (NCT05801887)
- Testing
- Extracorporeal shockwave device, No ESWT
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Metformin, CA Endometrium
Comparison of the Effectiveness Metformin for Deceasing Proliferative Marker in Endometrial Cancer Cells
Comparison of the effectiveness metformin versus placebo for deceasing proliferative marker Ki-67 expression in endometrial tumours when given for 4 weeks before hysterectomy in endometrial cancer cells.
- Trial name
- NCT03618472
- Testing
- Metformin Hydrochloride 850 MG
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Adenomatous Polyps
Curcumin for the Chemoprevention of Colorectal Cancer
Specific Aims: To determine if curcuminoids modulate cellular proliferation as measured by proliferating cell nuclear antigen (PCNA) in the colorectal mucosa of subjects with previously resected adenomatous colonic polyps.
- Trial name
- NCT00118989
- Testing
- Curcuminoids
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy Humans
Cranberry Enhances Human Immune Function and Reduces Illness
The purpose of this study is to determine whether consuming a beverage made with cranberry polyphenols and proanthocyanidins is effective in modifying immune function by enhancing immune cell proliferation, cytokine production…
- Trial name
- NCT01398150
- Testing
- Beverage made to look like the cranberry beverage, Beverage made from cranberry compounds
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Florida
Thyroid Cancer
SREBP1 as a Potential Biomarker Promotes Cell Proliferation and Invasion in Thyroid Cancer
In this study, the investigators detected the expression of SREBP1 in thyroid cancer tissues, explored the biological functions of SREBP1 in thyroid cancer cells.
- Trial name
- NCT04072731
- Testing
- pathologic
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- People's Hospital of Zhengzhou University
Healthy
Comparison of Proliferative Potential of H-PBSC Based on Demographics and Cryopreservation Time
The goal of this observational study is to observe stored stem cells and determine their capability to grow based on several factors.
- Trial name
- NCT05573412
- Testing
- Cellular analysis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Andrews Research & Education Foundation
Systemic Lupus Erythematosus, BAFF Polymorphism
BAFF and APRIL and RESPONSE TO BELIMUMAB in SLE
This project is intended to identify the routes on which BAFF and APRIL act in order to detect possible future candidates to Belimumab treatment among patients diagnosed of SLE.
- Trial name
- BAFF (NCT03919643)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Diabetes, Diabetes Mellitus
Discovering Early Biomarkers in Circulating Endothelial Cells for Diabetes Complications by Single Cell RNA Sequencing
The purpose of this study is to discover early biomarkers in circulating endothelial cells for diabetes complications, by investigating circulating endothelial cells in blood samples from patients with newly diagnosed…
- Conditions
- Diabetes, Diabetes Mellitus, Proliferative Diabetic Retinopathy, Diabetic Maculopathy
- Trial name
- CEC4DC (NCT05169502)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Cell Carcinoma
Establishment and Application of 3-Dimensional (3-D) Cell Culture Model of Clinical Circulating Tumor Cells (CTCs)
The goal of this observational study is to validate and evaluate the clinical feasibility of using a 3-D cell culture model for CTCs isolation/purification and their cell number expansion in cancer patient with transitional cell…
- Trial name
- NCT05623748
- Testing
- CTCs isolation/purification and cell number expansion
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Lymphoproliferative Disorders, Autoimmune Lymphoproliferative
Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation
Background: Blood stem cells in the bone marrow make all the cells to normally defend a body against disease. Allogeneic blood or marrow transplant is when these stem cells are transferred from one person to another.
- Conditions
- Lymphoproliferative Disorders, Autoimmune Lymphoproliferative, Primary T-cell Immunodeficiency Disorders, Immune System Diseases
- Trial name
- NCT03663933
- Testing
- e-ATG, Immunosuppression Only Conditioning, Reduced Intensity Conditioning
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Oxidative Stress, Stem Cell Research
Enriched Oxygen Mixtures in Athletes
Currently, Hyperbaric Oxigen (HBO) is a widely used treatment for several conditions. There are 14 indications for HBO, officially recognized by the Undersea and Hyperbaric Medical Society (UHMS), but research is discovering…
- Trial name
- OXY-SPORT (NCT04366427)
- Testing
- L-HBO, HBO, 30% O2
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Padova
Human Blood Cell Disorders, Lymphoid, Myeloid and Erythroid Proliferative Disease
Human Blood Cell Disorders Tissue Bank
The Human Blood Cell Disorder Tissue Bank will provide a convenient, comprehensive source of tissue containing populations of human blood cells from patients with various types of lymphoid, myeloid, and erythroid proliferative…
- Trial name
- NCT00902447
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy Volunteers Pharmacokinetic Study
Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK
The purpose of the study is to assess the safety, tolerability and PK of selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in healthy male Japanese and non-Japanese Asian volunteers following administration of a single dose.
- Trial name
- NCT01960374
- Testing
- Selumetinib
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Endometriosis
Proliferation of Endometrial Stromal Cells in Adenomyosis
Adenomyosis refers to the presence of endometrial glands and stroma that is haphazardly deep within the myometrium. However, the etiology and pathologic mechanism responsible for adenomyosis are not yet very well known.
- Trial name
- NCT00173212
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Humans
Immune Benefits From Mushroom Consumption
The purpose of this study is to determine whether consuming mushrooms is effective in enhancing the function of γδ T cells.
- Trial name
- NCT01398176
- Testing
- 3 ounces of mushrooms, 6 ounces of mushrooms
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Subjects
Single Center Study Of N-803 Stimulation On Expansion, Enrichment, Proliferation Of Natural Killer Cells Collected By Apheresis
This is phase 1 single cohort study evaluating the effects of N-803 administration on mononuclear cells (MNC) collected from healthy donors undergoing a procedure called apheresis.
- Trial name
- NCT06040918
- Testing
- N-803
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
Asthma
Role of Eosinophils in the Proliferation of Airway Smooth Muscle (ASM) Cells
Being a key player in Asthma, eosinophils constitute a potential target to interfere with the series of biological events leading to Asthma pathogenesis.
- Trial name
- NCT01082952
- Where
- Saudi Arabia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- King Saud University
Gastrointestinal Dysmotility
Enteric Neural Precursor Cells (ENPC) in the Human Gut
The study aim is to acquire human tissues to (a) understand the structure and organization of the human Enteric Nervous System; (b) perform a molecular transcriptomic profile of individual cells residing in the human gut; (c)…
- Trial name
- NCT04880538
- Testing
- Endoscopic procedure
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University