Clinical trials: Cell Transplantation
Hematopoietic Stem Cell Transplantation, Cell Transplantation
Biospecimen Procurement for Immunological Landscape Studies Following Hematopoietic Cell Transplantation
Background: Allogenic hematopoietic cell transplantation (HCT) is a procedure in which a person gets stem cells from a donor in order to treat their disease.
- Conditions
- Hematopoietic Stem Cell Transplantation, Cell Transplantation, Hematologic Malignancies
- Trial name
- NCT04428918
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Hematopoietic Stem Cell Transplantation
Post-transplantation Cyclophosphamide for Haploidentical Transplant From Maternal or Collateral Donors
In "beijing model" for haploidentical transplant, the rate of acute graft-versus-host disease (GVHD) from maternal or collateral donors was significantly higher than that from other kins.
- Trial name
- NCT02412423
- Testing
- post-transplantation cyclophosphamide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Haploidentical Hematopoietic Stem Cell Transplantation
Effect of NAC on the Hematopoietic Reconstitution After Haploidentical Hematopoietic Stem Cell Transplantation
The aim of the study is to evaluate the efficacy of the prophylactic administration of N-acetyl-L-cysteine (NAC) in acute leukemia patients with complete remission pre- and post-allotransplant on the occurrence of poor graft…
- Trial name
- NCT03236220
- Testing
- N-acetyl-L-cysteine
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Acute Myelogenous Leukemia, Allogeneic Stem Cell Transplantation
Bisantrene for Relapsed /Refractory AML
Induction of response in patients with AML that are either primary resistant (failed induction and or salvage therapy) or relapsed including post allogeneic stem cell transplantation and failed salvage therapy or cannot receive…
- Trial name
- NCT03820908
- Testing
- Bisantrene
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Fatigue, Leukemia
Effect of the Cycloergometer in Patients Undergoing Hematopoietic Stem Cell Transplantation
Physiological changes caused by hematological diseases associated with high dose chemotherapy have a negative impact on patient's functionality, making them more fragile and vulnerable after hematopoietic cell transplantation.
- Conditions
- Fatigue, Leukemia, Lymphoma, Multiple Myeloma
- Trial name
- NCT04496011
- Testing
- Aerobic training with cycle ergometer
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Transplantation, Pediatric ALL
mHealth Family Self-Management
This innovative research will address a gap in the literature involving the evaluation of the impact of an individualized family-centered mHealth application to enhance daily post-discharge communication following pediatric…
- Trial name
- myFAMI (NCT03533049)
- Testing
- myFAMI
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Medical College of Wisconsin
Invasive Aspergillosis, Acute Leukemia
Diagnostic Study of Combined Biomnarker Testing in Bronchoalveolar Lavage Samples of Immunocompromised Patients
The aim of our prospective and multicentre diagnostic study is therefore to elucidate on the sensitivity and specificity rates of these serologic markers in combination with molecular tools (both an Aspergillus specific and a…
- Conditions
- Invasive Aspergillosis, Acute Leukemia, Biomarkers, Stem Cell Transplantation
- Trial name
- NCT01695512
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Stem Cell Transplantation, Leukemia
Thiotepa-Clofarabine-Busulfan With Allogeneic Stem Cell Transplant for High Risk Malignancies
Any time the words "you," "your," "I," or "me" appear, it is meant to apply to the potential participant. The goal of this clinical research study is to learn if thiotepa, busulfan, and clofarabine, when given before an…
- Conditions
- Stem Cell Transplantation, Leukemia, Lymphoma
- Trial name
- NCT00857389
- Testing
- Thiotepa, Clofarabine, Busulfan
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Hematopoietic Stem Cell Transplantation, Cardiotoxicity
Effect of Angiotensin Converting Enzyme and Sacubitril Valsartan in Patients After Bone Marrow Transplantation
The purpose of the present study is to investigate the effect of ACE inhibitors and the sacubitril-valsartan complex in bone marrow transplant patients by assessing cardiovascular and endothelial parameters in order to search for…
- Trial name
- NCT04092309
- Testing
- ACE inhibitor, Sacubitril-Valsartan
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
Donor Lymphocyte Infusion, Allogeneic Hematopoietic Stem Cell Transplantation
Chemotherapy and DLI for Prevention of Second Relapse in Patients With Relapsed Acute Leukemia After Allotransplant
Patients with acute leukemia relapsing after allotransplant and who respond to anti-leukaemia interventions are at high-risk of a second relapse.
- Conditions
- Donor Lymphocyte Infusion, Allogeneic Hematopoietic Stem Cell Transplantation, Acute Leukemia, Minimal Residual Disease
- Trial name
- NCT03297528
- Testing
- donor lymphocyte infusion
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Hematopoietic Cell Transplantation Recipient
Positive Psychology Intervention to Improve Quality of Life in Stem Cell Transplant Survivors and Their Caregivers
This trial studies a positive psychology intervention designed to improve quality of life in stem cell transplant survivors and their caregivers.
- Trial name
- NCT03525106
- Testing
- Booklet, Exercise Intervention, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Fred Hutchinson Cancer Center
Autologous Hematopoietic Stem Cell Transplantation, Acute Myeloid Leukemia
IDA+BUCY vs BUCY Conditioning Regimen for Intermediate-risk AML Undergoing Auto-HSCT
Autologous hematopoietic stem cell transplantation (Auto-HSCT) is an effective alternative to allogeneic HSCT for intermediate-risk acute myeloid leukemia (AML) without HLA-matched donors.
- Conditions
- Autologous Hematopoietic Stem Cell Transplantation, Acute Myeloid Leukemia, Conditioning
- Trial name
- NCT02671708
- Testing
- Idarubicin（IDA）, Busulfan (BU), Cyclophosphamide (CY)
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Stem Cell Transplant Complications, Acute Graft-Versus-Host Disease
FMT for Steroid Resistant Gut Acute GVHD
The study aims to evaluate the safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of steroid resistant graft-versus-host-disease (GVHD) of the gut.
- Conditions
- Stem Cell Transplant Complications, Acute Graft-Versus-Host Disease, Fecal Microbiota Transplantation
- Trial name
- NCT04285424
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Hematopoietic Stem Cell Transplantation
Pilot Study Using Propranolol To Promote Prenylation Of Gtpase Rap1b In Hematopoietic Stem Cell Transplant Recipients
This is a an ancillary study designed to explore whether an additional cell signaling pathway (prenylation of Rap1) that was recently identified as being under beta-adrenergic control may be affected by beta-blocker use.
- Trial name
- NCT02535182
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical College of Wisconsin
Minimal Residual Disease, Donor Lymphocyte Infusion
MRD-directed Donor Lymphocyte Infusion for Reduce of Relapse After Allo-HSCT
Allogeneic hematopoietic cell transplantation (Allo-HSCT) is an effective therapy for acute leukemia, but relapse remains an important problem.
- Conditions
- Minimal Residual Disease, Donor Lymphocyte Infusion, Hematopoietic Stem Cell Transplantation, Relapse
- Trial name
- NCT02673008
- Testing
- donor lymphocyte infusion
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Autologous Hematopoietic Stem Cell Transplantation, Conditioning
Mel vs BUCY+VP-16 Conditioning Regimen for MM Undergoing Auto-HSCT
The purpose of this study is to evaluate the safety and efficacy of Melphalan and BUCY+VP-16 myeloablative conditioning regimens in multiple myeloma undergoing autologous hematopoietic stem cell transplantation.
- Conditions
- Autologous Hematopoietic Stem Cell Transplantation, Conditioning, Multiple Myeloma
- Trial name
- NCT03385096
- Testing
- Busulfan (BU), Cyclophosphamide (CY), Etoposide (VP-16)
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Chronic Lymphocytic Leukemia
Allogeneic Stem Cell Transplant for CLL
This phase I/II trial studies the best dose and side effects of gemcitabine and how well it works with clofarabine and busulfan and donor stem cell transplant in treating participants with chronic lymphocytic leukemia.
- Conditions
- Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Richter Syndrome
- Trial name
- NCT01629511
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin, Busulfan
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hematopoietic Cell Transplantation Recipient, Recurrent Plasma Cell Myeloma
Study of Personalized Melphalan Dosing in the Setting of Autologous Transplant
This randomized phase II trial studies the side effects and how well melphalan hydrochloride works in treating patients with multiple myeloma that has come back or does not respond to treatment.
- Conditions
- Hematopoietic Cell Transplantation Recipient, Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
- Trial name
- NCT03328936
- Testing
- Laboratory Biomarker Analysis, Melphalan Hydrochloride, Pharmacological Study
- Where
- United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Allogeneic Hematopoietic Stem Cell Transplantation
Co-transplantation of MSC in the Setting of Allo-HSCT
Mesenchymal stem cells (MSCs) are known to exhibit immunomodulatory, anti-inflammatory, and pro-angiogenic properties, and therefore have the potential to improve the outcome of allogeneic hematopoietic stem cell transplantation…
- Trial name
- NCT04247945
- Testing
- Cotransplant with MSCs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Blood And Marrow Transplantation, Leukemia
Infusion of Allogeneic, 3rd Party CD19-specific T Cells
The goal of this clinical research study is to learn if researchers can successfully and safely give patients who have had a stem cell transplant an infusion of white blood cells (called T-cells) that have been collected from an…
- Conditions
- Blood And Marrow Transplantation, Leukemia, Lymphoma
- Trial name
- NCT02274506
- Testing
- Cyclophosphamide, Fludarabine, T-Cell Infusion
- Sponsor
- M.D. Anderson Cancer Center