Clinical trials: Central Nervous Injury
Sports Injury, Concussion, Mild
Turkish Translation of SportsConcussion Assesment Tool 6
Concussions, a significant type of sports injury caused by head, face, or neck trauma, are common in contact sports and require serious attention due to potential fatal consequences of mismanagement.
- Conditions
- Sports Injury, Concussion, Mild, Concussion, Brain, Concussion, Severe
- Trial name
- SCAT 6-tr (NCT06739785)
- Testing
- SCAT6-tr
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ordu University
Traumatic Brain Injury, Ventilator Associated Pneumonia
Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocritical Care, Also Effect on Days of Ventilation and ICU Stay.
Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is…
- Trial name
- NCT04977843
- Testing
- EARLY BRONCHOALVEOLAR LAVAGE
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Hospital
Acquired Brain Injury, Depression
MAPLES Pilot Study for Low Mood in ABI
Low mood and depression are common following acquired brain injury (ABI). There is a lack evidence on effective treatments in ABI. Behavioural Activation (BA) is a potentially valuable option.
- Trial name
- MAPLES (NCT03874650)
- Testing
- Activity Planning Group, Activity Engagement Group, Waitlist Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Cambridge
Infant, Newborn, Infant, Low Birth Weight
Inflammatory Cytokines Associated With Perinatal Brain Injury
This observational study assessed whether measurements of certain pro-inflammatory and anti-inflammatory cytokines in the blood (either singly or in combination) at birth and/or up to day of life 21 can predict cerebral palsy at…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Cytokines (NCT01035697)
- Where
- 18 sites in United States
- Volunteers
- 1,067 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Traumatic Brain Injury
Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State
A randomised control trial of patients who have a severe brain injury to determine if patients who receive a standardised sensory stimulation program emerge earlier from a vegetative state.
- Trial name
- NCT00163878
- Testing
- Sensory Stimulation, Sesnory Modality Assessment and Rehabilitation Technique
- Where
- 2 sites in Australia
- Sponsor
- Bayside Health
D000784, D020521
CARbon Dioxide Flooding to Reduce Postoperative Neurological Injury Following Surgery for Acute Type A Aortic Dissection
Aortic dissection is a life-threatening condition and a consequence of a tear of the innermost of the three aortic layers- the intima.
- Trial name
- CARTA (NCT04962646)
- Testing
- Carbon dioxide flooding
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Brain Injuries, Traumatic
Mild TBI Assessment & Rehabilitation
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions.
- Trial name
- MTAR (NCT02920788)
- Testing
- Goal-Oriented Attentional Self-Regulation (GOALS), Brain Health Education (BHE), fMRI
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Stroke
Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury
Background: Previous research has shown that certain parts of the brain are involved in voluntarily stopping an ongoing motor response (movement); however, it is not known whether this same network is also involved in suppressing…
- Conditions
- Traumatic Brain Injury, Stroke, Headache, PTSD
- Trial name
- NCT01194661
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring…
- Trial name
- NCT03321370
- Testing
- Continuous electrocorticography post severe traumatic brain injury requiring neurosurgical intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Samuel Cramer
Spinal Cord Injuries
Understanding Experiences of People With Spinal Cord Injury Undergoing Activity-based Rehabilitation
Incomplete cervical spinal cord injury (SCI) makes up half of all the newly admitted patients. For these individuals, the use of their upper limbs is critical for managing daily activities and self-care and impacts their quality…
- Trial name
- NCT04000256
- Testing
- Activity based rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Cerebral Palsy, Traumatic Brain Injury
Hybrid Approach to Pediatric Rehabilitation
Children and youth recovering from acquired injuries typically receive therapy via in-patient or outpatient rehabilitation (OPR).
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Orthopedic Disorder
- Trial name
- NCT06547762
- Testing
- Hybrid approach (in-person and remote) to pediatric rehabilitation: A look beyond the COVID-19 crisis
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Peripheral Vascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery for Thrombosis and Bleeding
The proposed PIVOTAL study will examine a panel of platelet/coagulation activity markers during the perioperative period. The goal is to develop a clinically useful assessment of platelet/coagulation activity for risk…
- Conditions
- Peripheral Vascular Disease, Peripheral Artery Disease, Carotid Stenosis, Aortic Aneurysm, Abdominal
- Trial name
- PIVOTAL (NCT01897103)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Stroke, Brain Injuries
Investigating Usability of c-SIGHT in the Homes of Brain Injury Survivors
A brain injury can damage the brain, so that it no longer receives information about the space around one side of the world. If this happens, people may not be aware of anything on one side, usually the same side they also lost…
- Conditions
- Stroke, Brain Injuries, Spatial Neglect, Attention Deficit
- Trial name
- c-SIGHT (NCT03963661)
- Testing
- c-SIGHT (computorized spatial innatention grasping home-based therapy)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of East Anglia
Spinal Cord Injury
SCI Epidemiology and Complications
The aim of this study was to epidemiologically evaluate patients diagnosed with spinal cord injury who were admitted to our clinic over the last five years and, unlike similar studies, to investigate the presence of complications…
- Trial name
- NCT07425470
- Testing
- Retrospective data analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bandırma Onyedi Eylül University
Spinal Cord Injury
Functional Scaffold Transplantation Combined With Epidural Electrical Stimulation for Spinal Cord Injury Repair
The study is designed to assess the role of functional neural regeneration collagen scaffold transplantation combined with epidural electrical stimulation in spinal cord injury patients.
- Trial name
- NCT03966794
- Testing
- Epidural Electrical Stimulation, Functional scaffold & Epidural Electrical Stimulation
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Chinese Academy of Sciences
Insomnia, TBI (Traumatic Brain Injury)
Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury
The objective of the study is to conduct a randomized controlled trial of Cognitive Behavioral Therapy for Insomnia (CBT-I) in a sample of active-duty sailors with a history of traumatic brain injury (TBI).
- Trial name
- CBTBI (NCT06867666)
- Testing
- In Person CBT-I, CBT-I via COAST
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Noctem, LLC
Chronic Subdural Hematoma
Tranexamic Acid Therapy For The Treatment of Subdural Hematomas
This Phase II randomized, placebo-controlled, double-blinded trial is the first step in our endeavor to improve the clinical outcomes of patients with chronic subdural hematomas (cSDH).
- Trial name
- NCT06718751
- Testing
- Tranexamic Acid 650 MG
- Volunteers
- 240 people
- Sponsor
- Baylor College of Medicine
Spinal Cord Injuries, Aging
Exercise and Nutrition Education for Older Adults With Spinal Cord Injury: A Pilot Randomized Controlled Trial
Older adults living with a spinal cord injury (SCI) experience an increased burden of secondary health conditions than, coupled with age-related complications, may negatively affect physical and mental health, as well as…
- Trial name
- NCT07845851
- Testing
- Individualized Exercise Training, Nutrition Education, Behavioral Support
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Chronic Subdural Hematoma, Hemorrhage Brain
Microfabricated Microcatheter Advantages in Middle Meningeal Artery Embolization: an Early Experience at a Single Center
The purpose of this study is to evaluate the function of matched pair Aristotle 14 Guidewire and Plato Microcatheter in MMA embolization treatment for chronic subdural hematoma compared to surgeon's preference
- Trial name
- SCIENTIA (NCT07324551)
- Testing
- Matched pair Aristotle 14 guidewire and Plato 17 microcatheter, Surgeon combination preference
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Intensive Care Unit
Practice of Sedation and Analgesia in Patients With Severe Brain Injury in China
Sedation and analgesia is necessary management for patients in the intensive care units. The high-level studies of sedation and analgesia in China are still deficient, especially in patients with brain injuries who even have been…
- Trial name
- NCT03975751
- Testing
- The Glasgow Coma Scale (GCS)
- Where
- China
- Volunteers
- 387 people
- Sponsor
- Capital Medical University
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