Clinical trials: Central Nervous System Disease
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Dementia
Withdrawal of Antidementia Drugs in Advanced Dementia (WADAD)
Dementia is a chronic progressive mental disorder that adversely affects higher cortical functions, including cognition and behavior leading up to disability and dependence in daily life activities.
- Trial name
- WADAD (NCT05321680)
- Testing
- Treatment withdrawal
- Where
- Portugal
- Volunteers
- 16 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Postoperative Delirium
The Preventive Effect of Different Doses of Intranasal Insulin on Postoperative Delirium
Postoperative delirium is one of the common complications in the older aldults after surgery, which can lead to longer hospita stay，memory loss and reduced quality of life. There is currently no specific treatment.
- Trial name
- NCT06443957
- Testing
- Intranasal normal saline, Intranasal insulin-20U, Intranasal insulin-40U
- Where
- China
- Volunteers
- 129 people
- Sponsor
- The First Hospital of Jilin University
PD - Parkinson's Disease
Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease
The purpose of this study is to test a new way to treat Parkinson's disease (PD). Subjects will be implanted with deep brain stimulator (DBS) devices and electrodes placed under the scalp.
- Trial name
- Subgaleal aDBS (NCT07398157)
- Testing
- Medtronic Percept Deep Brain Stimulation (cDBS), Medtronic Percept Deep Brain Stimulation (daytime aDBS), Medtronic Percept Deep Brain Stimulation (nighttime aDBS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Thrombus, Brain, Thrombosis
Thrombus Imaging and Treatment Analytics in Neurology
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and…
- Trial name
- Titan (NCT05663281)
- Testing
- thrombus imaging appearance
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Respiratory Tract Infection, Smell Disorder
Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)
Background: Loss of the sense of smell can seriously affect a person's quality of life. The ability to smell can be damaged by many factors, including illnesses, injuries, and exposure to toxic chemicals.
- Conditions
- Respiratory Tract Infection, Smell Disorder, Influenza, Rhinosinusitis
- Trial name
- NCT07149428
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Anticoagulation, Atrial Fibrillation
AntiCoagulation Tracking InterVention and Evaluation
Anticoagulants are a leading cause of acute injury from adverse drug events, leading to ~20,000 serious injuries reported to the Food and Drug Administration per year and more than 220,000 emergency department visits annually.
- Conditions
- Anticoagulation, Atrial Fibrillation, Atrial Flutter, Pulmonary Embolus/Emboli
- Trial name
- ACTIVE (NCT04059965)
- Testing
- Panel Management for Anticoagulation Therapy, Usual Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
GM2 Gangliosidosis, Tay-Sachs Disease
N-Acetyl-L-Leucine for GM2 Gangliosidosis (Tay-Sachs and Sandhoff Disease)
This is a multinational, multicenter, open-label, rater-blinded prospective Phase II study which will assess the safety and efficacy of N-Acetyl-L-Leucine (IB1001) for the treatment of GM2 Gangliosidosis (Tay-Sachs and Sandhoff…
- Conditions
- GM2 Gangliosidosis, Tay-Sachs Disease, Sandhoff Disease
- Trial name
- NCT03759665
- Testing
- IB1001
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- IntraBio Inc
Hemiplegia, Cerebral Palsy
Relationship Between Isometric Muscle Strength and Gross Motor Function in Children With Unilateral Cerebral Palsy
Muscle strength can be defined as the ability of skeletal muscle to develop force for the purpose of providing stability and mobility within the musculoskeletal system, so that functional movement can take place.
- Trial name
- NCT05614167
- Testing
- correlation
- Where
- Egypt
- Volunteers
- 97 people
- Sponsor
- Badr University
Stroke, Caregiver Social Support
Optimizing Stroke Family Caregiver Support Across the Care Continuum by Improving the Timing of Intervention Delivery
About 50% of stroke survivors have limitations in their activities of daily living on return to the community. Family caregivers provide invaluable support to these individuals during their recovery and rehabilitation.
- Conditions
- Stroke, Caregiver Social Support, Caregiver Mental Health, Caregiver Sense of Control Over Life
- Trial name
- NCT00958607
- Testing
- Timing it Right Stroke Family Support Person Intervention, Self-directed program
- Where
- Canada
- Volunteers
- 310 people
- Sponsor
- University of Toronto
Alzheimer Disease
Testing the Effects of a Text Message Caregiver Support Intervention for Latinos
The goal of this randomized clinical trial it to test the efficacy of CuidaTEXT, the first Alzheimer's disease and Related Dementias (ADRD) caregiver support intervention to capitalize on text messaging, among Latinos.
- Trial name
- CuidaTEXT R01 (NCT06728436)
- Testing
- CuidaTEXT
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cerebral Vasospasm
The Intra-arterial Vasospasm Trial
The primary objective of the study is to determine the optimal intra-arterial drug treatment regimen for arterial lumen restoration post cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
- Trial name
- iVAST (NCT01996436)
- Testing
- Nicardipine, Verapamil, Nicardipine + Verapamil + Nitroglycerin
- Where
- 5 sites in United States
- Volunteers
- 92 people
- Sponsor
- Peng Roc Chen, MD
Carotid Stenosis
Melatonin in Patients Under Carotid Endarterectomy
The main purpose of this study is to evaluate the effects of melatonin in the regulation of the vascular injury in patients under carotid endarterectomy through population-based, randomized, double-blind, placebo-controlled trial.
- Trial name
- NCT03115034
- Testing
- Melatonin, blank
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Parkinson Disease
Vinpocetine in Patients With Parkinsonian Disease
The clinical manifestations of Parkinson's disease (PD), a chronic neurodegenerative condition, include resting tremor, hypokinesia, bradykinesia, stiffness and postural instability.
- Trial name
- NCT07229664
- Testing
- Levodopa Carbidopa, Vinpocetine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Traumatic Brain Injury, Hemorrhage
Fibrinogen Concentrate in Isolated Traumatic Brain Injury
Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness.
- Trial name
- NCT03304899
- Testing
- RiaSTAP Injectable Product
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Leila Dehghani
Amyotrophic Lateral Sclerosis
EIM Via the Myolex mScan as an ALS Biomarker
Amyotrophic lateral sclerosis (ALS) has been traditionally considered incurable and untreatable. But starting in the 1990s with the introduction of Riluzole, therapies are being discovered and ultimately approved for slowing…
- Trial name
- ElectricALS (NCT06491732)
- Testing
- Electrical Impedance Myography
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- Beth Israel Deaconess Medical Center
Epilepsy
AI-enhanced LF-MRI in Epilepsy
The global burden of epilepsy is high affecting over 50 million people worldwide. Majority live in low- and middleincome countries (LMICs) where access to diagnosis and treatment is limited.
- Trial name
- ALF-ME (NCT07717632)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- University College, London
Developmental Disability, Autism Spectrum Disorder
The Effects of Virtual Zumba® in Individuals With Developmental Disabilities
There are critical knowledge gaps that need to be addressed to understand the impact of aerobic exercise programs on relevant functional outcomes in adults with developmental disabilities (DD).
- Conditions
- Developmental Disability, Autism Spectrum Disorder, Down Syndrome, Cerebral Palsy
- Trial name
- NCT05198232
- Testing
- Zumba High Tempo, Zumba Low Tempo
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Auburn University
Partial Epilepsy
Randomized Controlled Trial to Assess Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy
Sleepiness and fatigue are the most common complaints of people with epilepsy and can have a negative impact on quality of life. Though unproven, these problems are often blamed on anti-seizure medications.
- Trial name
- NCT01190098
- Testing
- Lacosamide
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- The Cleveland Clinic
Tourette Syndrome
Efficacy of a Therapeutic Combination of Dronabinol and PEA for Tourette Syndrome
This is an investigator-initiated proof of concept study with the purpose to examine the safety, tolerability and feasibility of Dronabinol (synthetic Δ9-THC) and PEA for the treatment of adults with Tourette syndrome.
- Trial name
- NCT03066193
- Testing
- Dronabinol and Palmitoylethanolamide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
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