Clinical trials: Central Nervous System Inflammation
Biomarker, Lipid
Shotgun Mass Spectrometry-based Lipid Profiling in Chronic Inflammatory Diseases
Collect blood from patients admitted for coronary angiography to tubes with heparin, centrifuge and collect plasma. This will be frozen at -80C.
- Conditions
- Biomarker, Lipid, Inflammation, Cardiovascular Diseases
- Trial name
- NCT04786431
- Testing
- Blood collection for lipid profiling by LC-MS
- Volunteers
- 427 people
- Sponsor
- Universidade Nova de Lisboa
Adult, Intensive Care Unit
Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients
Delirium is common in septic patients, especially those receiving mechanical ventilation in the intensive care unit (ICU). Dexmedetomidine is a highly selective α2 adrenoreceptor agonist with anxiolytic, sedative, analgesic, and…
- Conditions
- Adult, Intensive Care Unit, Sepsis, Mechanical Ventilation
- Trial name
- NCT04876937
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University First Hospital
Spinal Cord Injury, Inflammation
Effect of Sham Anti-inflammatory Diet on Inflammation After Spinal Cord Injury
This pilot study will evaluate the effects of a placebo anti-inflammatory diet in individuals with spinal cord injury. It is being performed to ensure that the placebo diet does not induce reductions in inflammation and also…
- Trial name
- NCT04271904
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Carotid Artery Diseases, Carotid Artery Stenosis
A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
There are 10.3 million cases of stroke registered in the world every year; 63% of them lead to death. According to World Health Organization, stroke is one of the most important risk factors of death and early disability.
- Trial name
- NCT05126238
- Testing
- Lithium Carbonate
- Where
- Russia
- Volunteers
- 107 people
- Sponsor
- Negovsky Reanimatology Research Institute
Carotid Stenosis, Caloric Restriction
Short-Term Endogenous Hydrogen Sulfide Upregulation
This research study will compare the impact of dietary restriction pre-operatively before carotid endarterectomy compared to the standard nutrition that a patient typically eats.
- Trial name
- NCT03303534
- Testing
- ScandiShake
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Brigham and Women's Hospital
Cirrhosis, Hepatic Encephalopathy
Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement
Hypothesis: Improvement in cognitive dysfunction with IV albumin in patients with cirrhosis with prior HE and MHE lasts for several weeks after albumin infusion has ended, and is due to persistent improvement in inflammatory…
- Trial name
- HEAL-LAST (NCT06052176)
- Testing
- Albumin Infusion
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Multiple Organ Failure, End Stage Cardiac Failure
Timing of Acute Palliative Care Consultation in Critically Ill Patients
A prospective randomized controlled trial studying the ordering of palliative care consultations in the emergency department (Ig) versus later palliative care consultations in the hospital--ICU or hospital ward(Cg).
- Conditions
- Multiple Organ Failure, End Stage Cardiac Failure, End Stage Chronic Obstructive Airways Disease, Chronic Kidney Disease Stage 5
- Trial name
- NCT02858778
- Testing
- Early order of palliative care consultation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Critical Illness, Sepsis
Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE)
In this multicenter project, we will introduce AWARE (electronic interface) Using a cloud-based technology . The goal of this project is to improve compliance with best practice through the use of a new acute care interface with…
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- AWARE (NCT02039297)
- Testing
- Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation
- Where
- 6 sites in United States
- Volunteers
- 7,813 people
- Sponsor
- Mayo Clinic
Alzheimer Disease, Dementia
A Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation
The goal of this Phase 2 Alzheimer's study is to determine whether 1.0 mg/kg XPro1595 confers a benefit on cognition, function, and biomarkers of white matter and to further evaluate safety and tolerability.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- MINDFuL (NCT05318976)
- Testing
- XPro1595
- Where
- 41 sites in Australia, Canada and 6 more
- Volunteers
- 207 people
- Sponsor
- Inmune Bio, Inc.
Congestive Heart Failure, Infections
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
There is evidence to suggest that patients make different end-of-life decisions if they understand the risks, benefits and alternatives of CPR and mechanical ventilation.
- Conditions
- Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure
- Trial name
- NCT01878968
- Testing
- Script and CPR/Mechanical ventilation video.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Cardiovascular Diseases, Acute Coronary Syndrome
The IndONEsia ICCU Registry: a Multicenter Cohort of Intensive Cardiovascular Care Units Patients in Indonesia
Patients in the Intensive Cardiovascular Care Unit (ICCU) often present with cardiovascular disease (CVD) issues accompanied by various non-cardiovascular conditions.
- Conditions
- Cardiovascular Diseases, Acute Coronary Syndrome, Heart Failure, Heart Disease, Coronary
- Trial name
- NCT06265714
- Where
- 9 sites in Indonesia
- Volunteers
- 12,950 people
- Sponsor
- Universitas Indonesia
CNS Infection, Inner Ear Hearing Loss
CNS Infections Effect on the Inner Ear
Study on patients with CNS infections.
- Conditions
- CNS Infection, Inner Ear Hearing Loss, Vestibular Abnormality, Inner Ear Inflammation
- Trial name
- NCT03715569
- Testing
- Vestibular function, OAE/WBT, Biomarker
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Alzheimer Disease
Exploratory Study of Low-Dose Whole-Brain Radiation Therapy With HeLaXON 1X in Patients With Mild Alzheimer's Disease Dementia
This randomized, sham-controlled, exploratory clinical trial will evaluate the efficacy and safety of HeLaXON, an investigational low-dose radiation therapy device, in patients with mild Alzheimer's disease dementia.
- Trial name
- LDRT-AD-03 (NCT07863011)
- Testing
- HeLaXON 1X Low-Dose Radiation Therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- ReadyCure Inc.
Traumatic Brain Injury
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new…
- Trial name
- OVERCOME-TBI (NCT06927063)
- Testing
- blood-based protein biomarker assessments, blood-based metabolomic/lipidomic biomarker assessments, Diffusion-weighted magnetic resonance imaging (brain)
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Stroke, Acute, Pneumonia, Bacterial
Search for Biomarkers of Infection and Inflammation in Patients With Acute Stroke.
This study will look for new biomarkers of infection and evaluate current biomarkers of infection in stroke patients. Patients with acute stroke will be monitored with daily blood samples for seven days and by clinical…
- Trial name
- IBIS (NCT03812666)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Jakob Ström
HIV-Associated Cognitive Motor Complex
Mild Neurocognitive Disorder in HIV Infection of the Brain
Background: Some people with human immunodeficiency virus (HIV) develop problems with thinking and concentration when the virus affects the brain. This is known as mild neurocognitive disorder (MND).
- Trial name
- NCT01547754
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Unruptured Cerebral Aneurysm, Hemifacial Spasm
Effect of Acupuncture on Inflammation and Immune Function After Craniotomy
The aim of this study is to evaluate the effect of acupuncture on inflammation and immune function after craniotomy. This study will be a single-center, parallel group clinical trial that will be conducted at Kyung Hee University…
- Conditions
- Unruptured Cerebral Aneurysm, Hemifacial Spasm, Brain Tumor
- Trial name
- NCT02761096
- Testing
- acupuncture, conventional treatment
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Kyunghee University Medical Center
Trans Cranial Doppler Ultrasonography in Heamodynamic Optimisation in Septic Shock
Hemodynamic Optimisation Guided With Transcranial Doppler in Septic Shock
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic Shock, at the early phase. patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin doses: Group 1…
- Trial name
- NCT04398069
- Testing
- hemodynamic optimisation aiming to achieve normal cerebral perfusion
- Where
- Tunisia
- Volunteers
- 24 people
- Sponsor
- Mongi Slim Hospital
Cancer, Cardiac Disease
A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders
Rural patients with life-limiting illness are at very high risk of not receiving appropriate care due to a lack of health professionals, long distances to treatment centers, and limited palliative care (PC) clinical expertise.
- Conditions
- Cancer, Cardiac Disease, Pulmonary Disease, Neuro-Degenerative Disease
- Trial name
- NCT03767517
- Testing
- Active Intervention, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 209 people
- Sponsor
- University of Alabama at Birmingham