Clinical trials: Cerebellar Stroke, active
Acute Ischemic Stroke
Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
This study aims to test whether transcranial temporal interference stimulation (tTIs) can improve upper limb motor function in patients in the early subacute stage after acute ischemic stroke.
- Trial name
- TIMES (NCT07896629)
- Testing
- Transcranial Temporal Interference Stimulation (tTIs)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Post-stroke Cognitive Impairment, Ischemic Stroke
HOPE From the Cerebellum: TMS-Induced Cognitive Recovery After Stroke
The objective of this clinical trial is to investigate the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in the cerebellum for individuals with post-stroke cognitive impairment.
- Trial name
- HOPE (NCT06316557)
- Testing
- iTBS group, control group
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zi-Xiao Li
Post Stroke Spasticity, Dystonia
Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.
The aim of this clinical trial is to determine whether deep brain stimulation (DBS) interventions improve rehabilitation and functional recovery in patients with post-stroke spasticity who meet the other inclusion criteria listed…
- Trial name
- NCT07190092
- Testing
- Deep brain stimulation electrode implantation with an electrode target in the dentate nucleus
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Jan Biziel University Hospital No 2 in Bydgoszcz
Cerebellar Stroke, Autoimmune Cerebellar Disorders
Brain Stimulation to Improvement After Cerebellar Damage
The work will examine the mechanisms and potential therapeutic effects of transcranial magnetic stimulation on upper-limb sensorimotor function in individuals with cerebellar dysfunction, including those with damage due to stroke…
- Trial name
- NCT07838961
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- George Wittenberg
Stroke, Cerebellum
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes.
- Trial name
- NCT06458153
- Testing
- Neural responses to speech functional localizer, Neural responses to silent articulation, Neural responses to self vs. externally generated speech
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Leukodystrophy, White Matter Disease
The Myelin Disorders Biorepository Project
The Myelin Disorders Biorepository Project (MDBP) seeks to collect and analyze clinical data and biological samples from leukodystrophy patients worldwide to support ongoing and future research projects.
- Conditions
- Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome
- Trial name
- MDBP (NCT03047369)
- Where
- 23 sites in United States
- Volunteers
- 12,000 people
- Sponsor
- Children's Hospital of Philadelphia
Stroke, Trauma
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40.
- Conditions
- Stroke, Trauma, Cognition, Agency
- Trial name
- FUSCBM (NCT07389447)
- Testing
- Focused ultrasound, EEG
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Stroke, Hemiparesis After Stroke
Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Lower Extremity in Chronic Stroke Patients
This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of lower…
- Conditions
- Stroke, Hemiparesis After Stroke, Chronic Stroke Patients, Hemiplegia
- Trial name
- NIMBLE (NCT07073235)
- Testing
- Intermittent Theta Burst Stimulation
- Where
- Sweden
- Volunteers
- 56 people
- Sponsor
- Danderyd Hospital
Deglutition Disorders, Ischemic Stroke
Dentate-Targeted Temporal Interference Stimulation for Post-Stroke Dysphagia
The goal of this clinical trial is to learn whether individualized transcranial temporal interference stimulation can improve swallowing in adults with swallowing difficulties after an ischemic stroke.
- Trial name
- DENTIS-PSD (NCT07766668)
- Testing
- Active Transcranial Temporal Interference Stimulation, Standardized Task-Specific Swallowing Rehabilitation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhejiang University
Neurologic Disorder, Stroke
Home Based Tele-exercise for People With Chronic Neurological Impairments
To assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI).
- Conditions
- Neurologic Disorder, Stroke, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- Telex (NCT04564495)
- Testing
- Seated exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Burke Medical Research Institute
Chronic Cerebellar Stroke, Healthy Individuals (Controls)
Bimanual Motor Skill Learning Through Robotics in Chronic Cerebellar Stroke Survivors and Healthy Individuals
To test capacity of chronic cerebellar stroke patients and healthy individuals to learn and retain a complex bimanual motor skill, trained on the neurorehabilitation robot REAplan® (bimanual version).
- Trial name
- NCT04642599
- Testing
- Bimanual motor skill learning with the REAplan® rehabilitation robot
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Dysphagia After Stroke
Cerebellar Transcranial Direct Current Stimulation for Dysphagia After Supratentorial Stroke
It is estimated that 400,000 to 800,000 people worldwide develop neurogenic dysphagia annually. Stroke represents the most common etiology, with approximately 65% of acute stroke patients experiencing pharyngeal swallowing…
- Trial name
- NCT07212634
- Testing
- Transcranial Direct Current Stimulation
- Volunteers
- 76 people
- Sponsor
- Zhejiang Provincial People's Hospital
Cerebellar Ataxia, Cerebellar Diseases
Individualized Neuro-Modulation Paired With Cerebellar Therapy
The purpose of this project is to evaluate feasibility and preliminary efficacy of pairing personalized transcranial direct current stimulation (tDCS) with individualized rehabilitation therapy in people with cerebellar damage.
- Conditions
- Cerebellar Ataxia, Cerebellar Diseases, Cerebellar Stroke, Cerebellar Tumor
- Trial name
- IMPACT (NCT07642856)
- Testing
- Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Post-stroke Depression
To Explore the Neural Processing Mechanism of Cerebellum Involved in Facial Expression Recognition Based on Transcranial Magnetic Stimulation
Experiment 1: Utilizing a transcranial magnetic stimulation-electroencephalography/functional near-infrared spectroscopy system, the investigators aim to determine whether transcranial magnetic stimulation of the cerebellum can…
- Trial name
- NCT06860451
- Testing
- TMS
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Stroke
Cerebellar Deep Brain Stimulation or VNS for Chronic Post-stroke Motor Rehabilitation
Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts.In this open-label, randomized phase I trial, we applied deep brain stimulation to the cerebellar…
- Trial name
- NCT06303960
- Testing
- Bilateral Cerebellar deep brain stimulation, Unilateral Cerebellar deep brain stimulation, Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Hemispatial Neglect, Visual Neglect
Cerebellum and Neglect
The goal of this clinical trial is to learn if a non-invasive brain stimulation method called continuous theta burst stimulation (cTBS) can improve attention in adults who have hemispatial neglect after stroke.
- Conditions
- Hemispatial Neglect, Visual Neglect, Stroke
- Trial name
- NCT07580066
- Testing
- Continuous theta burst stimulation
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Luzerner Kantonsspital
Stroke
Cerebellar Stimulation for Aphasia Rehabilitation
The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in…
- Trial name
- CeSAR (NCT05093673)
- Testing
- Cathodal Cerebellar tDCS, Semantic Feature Analysis (SFA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Aphasia, Stroke
Cerebellar Brain Stimulation Plus Language Therapy for People at Risk of Poor Aphasia Recovery After Stroke
This pilot study tests whether a mild form of brain stimulation to the cerebellum, combined with computer-based language therapy, helps people recover language after a stroke when a poor natural recovery is predicted.
- Conditions
- Aphasia, Stroke, Anomia
- Trial name
- PART-CN (NCT07912242)
- Testing
- Cathodal cerebellar transcranial direct current stimulation, Computerized language therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Post-stroke Depression
Investigating How the RECT Impacts Brain Functional States Through the ACC-cerebellar Loop
Experiment1: Using a brain EEG-TMS combined system, researchers aim to investigate the impact of the rostral anterior cingulate cortexr (rACC)-engaging cognitive task (RECT) combined single-pulse TMS magnetic stimulation on theta…
- Trial name
- NCT06912191
- Testing
- Left cerebellar TMS stimulation combined with the RECT task, Right cerebellar TMS stimulation combined with the RECT task, Midline cerebellar TMS stimulation combined with the RECT task
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Stroke, Stroke, Cardiovascular
EMG Control Assistance Virtual Reality Interface Coupled With Cerebellar-iTBS for Arm Recovery After Stroke (ERICA)
The investigators hypothesize that a myoelectric (EMG) controlled virtual reality (VR) interface allows for effective upper limb motor recovery of stroke patients.
- Trial name
- ERICA (NCT06911671)
- Testing
- Virtual Reality Interface + Cerebellar iTBS (c-iTBS), Physical Therapy
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia