Clinical trials: Cerebellum
Stroke, Hemiparesis
Recovery of Motor Skills With the Use of Artificial Intelligence and Computer Vision
To investigate the impact of algorithms utilizing artificial intelligence technology and computer vision on the recovery of motor functions within the context of rehabilitation practice for patients who have experienced a…
- Conditions
- Stroke, Hemiparesis, Spasticity as Sequela of Stroke, Dysmetria
- Trial name
- NCT06183970
- Testing
- AssistI patients, Habilect patients
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health
Parkinson Disease, Healthy Adult
Multiple Sessions of Transcranial Direct Current Stimulation in People With Parkinson's Disease
Parkinson's disease (PD) affects approximately 1 million people in the US, with annual health care costs approaching $11 billion. PD results from a loss of dopamine-producing cells in the brain.
- Trial name
- NCT04762823
- Testing
- Cerebellar transcranial direct current stimulation at 4 mA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Iowa
Autosomal Dominant Spinocerebellar Ataxia (SCA1, 2,3,6,7,27B)
Autosomal Dominant Spinocerebellar Ataxias and Social Cognition
Spinocerebellar ataxias are a group of rare neurodegenerative diseases, clinically and genetically highly heterogeneous, with an estimated mean prevalence of 2.7 per 100,000 population.
- Trial name
- SoCoSca (NCT07099651)
- Testing
- tests
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Attention Deficit Disorder With Hyperactivity
Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD)
The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- TDA/H (NCT00684931)
- Testing
- Imaging
- Where
- 2 sites in France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Stroke
How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?
Combining cortical tDCS with behavioral interventions has been shown to have beneficial outcomes in individuals post-stroke. However, cerebellar tDCS is a fairly new approach for individuals with unilateral cortical stroke and…
- Trial name
- NCT06384495
- Testing
- REAL-A, REAL-C
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke, Cerebellum
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes.
- Trial name
- NCT06458153
- Testing
- Neural responses to speech functional localizer, Neural responses to silent articulation, Neural responses to self vs. externally generated speech
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Injury Brain, Eye Abnormalities
Reading Problems Associated With Central Nervous System (CNS) Pathologies.
This project aims to analyse eye movements, their alterations and influence in reading performance in patients with acquired CNS diseases and compare them with people of the same age, without neurological or ocular pathology and…
- Conditions
- Injury Brain, Eye Abnormalities, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT04937725
- Testing
- eye tracking
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Brain Function, Cerebral Palsy
7T Anatomo-functional Characterization of Structures in the Action Observation Network
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the…
- Trial name
- 7T-ATHENA (NCT06826287)
- Testing
- 7T MR exam, clinical assessment
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Essential Tremor
Cerebellar Research in Ultrasound Stimulation
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design.
- Trial name
- CERBERUS (NCT07508696)
- Testing
- Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Verticality Perception, Self-motion Perception
Altered Vestibular Perception and Transcranial Magnetic Stimulation
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation.
- Trial name
- NCT02184130
- Testing
- transcranial magnetic stimulation and motion stimuli
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Friedreich's Ataxia
Patient Registry of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)
This is a multi-centre, multi-national, prospective, observational study of Friedreich's Ataxia (FRDA) with a control group to: obtain natural history data on individuals affected by FRDA relate clinical assessments and results…
- Trial name
- EFACTS (NCT02069509)
- Where
- 16 sites in Austria, Belgium and 8 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- European Friedreich's Ataxia Consortium for Translational Studies
Friedreich's Ataxia
Biomarkers in Friedreich's Ataxia
The purpose of this project is to characterize measures of cardiac performance and neuromuscular physiology in FA patients using novel techniques, including echocardiography and magnetic resonance imaging (MRI), metabolic…
- Trial name
- NCT02497534
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Florida
Autism Spectrum Disorder
Modulation of the Activity of the Cerebellum in Autism (MACA)
Research on the involvement of the cerebellum in social understanding behavior and the mentalizing brain system has just begun. Knowledge about the neurobiology of social understanding is important for understanding the ways to…
- Trial name
- MACA (NCT05781412)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beatriz Catoira
Primary Dystonia
Contribution of the Cerebellum In Sensory-motor Adaptation Via Gamma Oscillations: the Case of Dystonia
Dystonia, a disabling disease with uncontrolled movement disorders was considered to be a manifestation of basal ganglia dysfunction, yet there is accumulating evidence from animal and human experiments that the cerebellum plays…
- Trial name
- GAMMA (NCT02073630)
- Testing
- active cerebellar stimulation
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke
Manual Dexterity Control After Cerebellar Stimulation
This study will assess the putative advantages of cerebellar stimulation on motor learning abilities of stroke patients. In order to have a control group to refer to, the effect of cerebellar stimulation on healthy young and old…
- Trial name
- MADECCS (NCT03092570)
- Testing
- With stimulation, No stimulation
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Brain Cancer
Controlling Coordination After Childhood Cerebellar Cancer, a Pilot Study
Posterior fossa tumours (PFT) account for 2/3 of childhood brain cancers. They can be highly malignant requiring combined chemotherapy and radiotherapy post-surgery for a >50% chance of cure.
- Trial name
- 5C-pilot (NCT04501731)
- Testing
- Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Imaging (MRI), Motor assessment
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Autosomal Recessive Cerebellar Ataxia
Validation of the RADIAL Algorithm for Diagnosis of Autosomal Recessive Cerebellar Ataxia
RADIAL is an algorithm which has been developed following a review of the literature on 67 autosomal recessive cerebellar ataxias (ARCA) and personal clinical experience.
- Trial name
- RADIAL-VALID (NCT04261127)
- Testing
- Genetic diagnosis (PMDA panel), Use of RADIAL algorithm
- Where
- 8 sites in France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Vestibular Disorder, Fall
Vestibular Rehabilitation for Chronic Central Vestibular Deficits: A Case Study
The purpose of this study is to assess the effectiveness of vestibular rehabilitation for an individual who has chronic central vestibular deficits due to cerebellar dysfunction.
- Conditions
- Vestibular Disorder, Fall, Coordination and Balance Disturbances
- Trial name
- NCT03952936
- Testing
- Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Methodist University, North Carolina
Spinocerebellar Ataxia (SCA)
Electrical Stimulation Cycling Training Effects on SCA
To focuses on the challenges faced by individuals with spinocerebellar ataxia (SCA), highlighting the major clinical sign of ataxia that affects their stability and ability to perform daily activities, thereby impacting their…
- Trial name
- NCT06363058
- Testing
- ES Cycling Training
- Where
- Taiwan
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Appetitive Behavior, Obesity
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the…
- Trial name
- NCT06105164
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital