Clinical trials: Cerebral Blood Flows
Stroke, High Intensity Interval Exercise
Blood Flow Response and Acute INterval Exercise
The objective of this project is to study the cerebrovascular response to a single bout of high intensity interval exercise (HIIT) in 25 individuals with chronic stroke compared to 25 age- and sex- matched healthy controls (CON).
- Trial name
- BRAIN (NCT04673994)
- Testing
- Single, acute bout of high intensity interval exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Dementia
BOLD Functional Magnetic Resonance Imaging (fMRI) and Cerebral Blood Flow Measurements as Biomarkers for Cognition Enhancing Drugs (3134-006)
This study will evaluate functional magnetic resonance imaging (fMRI) and methods for measuring drug induced changes in cerebral blood flow as biomarkers for attention-improving drugs.
- Trial name
- NCT00887601
- Testing
- MK3134, Donepezil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cerebral Blood Flow, Cognitive Function
Effects of Docosahexaenoic Acid (DHA)-Rich Fish Oil on Cerebral Haemodynamics
DHA has previously been shown to increase regional cerebral blood flow response to tactile stimulation in aged monkeys; modulation of cerebral blood flow in humans has yet to be demonstrated.
- Trial name
- NCT01075932
- Testing
- DHA-rich fish oil
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Obesity
Ingestion of Lipids and Changes in Cerebral Blood Flow of People With Obesity
This study aims to determine changes in cerebral blood flow of people with obesity after the ingestion of fat.
- Trial name
- NCT02079116
- Testing
- 60 grams of fat plus water solution, Pure water
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Partial Epilepsy
Serotonin Receptors in Seizure Disorders
Patients in this study will undergo PET scans (a type of nuclear imaging test) to look for abnormalities in certain brain proteins associated with seizures.
- Trial name
- NCT00001932
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Iron, Cerebral Blood Flow
16 Weeks' Dietary Supplementation With Iron and Iron + Vitamin C on Cerebral Blood Flow and Energy Expenditure in Women of Reproductive Age
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Conditions
- Iron, Cerebral Blood Flow, Energy Metabolism, Cognitive Function
- Trial name
- NCT04477018
- Testing
- Iron bis-glycinate chelate and vitamin C, Iron bis-glycinate chelate
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive Decline
Investigate the Effect of Tart Montmorency Cherry Juice (Prunus Cerasus) on Cerebral Blood Flow and Cognitive Function
Scientific studies in humans suggest that diets high in fruit and vegetables may be able to improve some aspects of mental performance such as improving memory and reaction times.
- Trial name
- NCT02381860
- Testing
- 60mL tart Montmorency cherry juice
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Headache, Migraine
Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2
Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of…
- Trial name
- NCT00374530
- Testing
- PGE2
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Healthy
Measuring Blood Flow in the Brain
This study will test a method of measuring brain blood flow called near infrared spectroscopy (NIRS). It will determine whether NIRS gives the same results as the more commonly used technique, functional magnetic resonance…
- Trial name
- NCT00466934
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Idiopathic Intracranial Hypertension
Multimodal MRI Assessment of Brain Fluid Circulation in Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by increased pressure inside the skull without an identifiable cause.
- Trial name
- NCT07915453
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Healthy Volunteer
Caloric Stimulation on Cerebral Blood Flow
This is a prospective, non-randomized study designed to generate preliminary data to assess the effect of a new portable non-invasive caloric stimulator on EEG waveform and cerebral blood flow on normal healthy volunteers.
- Trial name
- NCT01629901
- Testing
- ThermoNeuroModulation (TNM) Device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Cushing Syndrome, Hypercortisolism
Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients
This cross-sectional, single-center study will assess the microvascular function using a nailfold video-capillaroscopy in patients with endogenous Cushing syndrome.
- Trial name
- NCT04433819
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marmara University
PreDiabetes
Study: Diet and Exercise Study to Improve Brain Blood Flow: Blood Flow Improvement Trial
Project Summary Metabolic syndrome (MetS) is associated with the development of diabetes and cardiovascular disease; however it is also linked with cognitive decline and dementia.
- Trial name
- BFIT (NCT03117829)
- Testing
- Diet and Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Brain Vascular Function, Cerebral Blood Flow
Effects of Peanut Consumption on Brain Function
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Brain Insulin Sensitivity, Cognitive Performance
- Trial name
- NCT05724654
- Testing
- Skin roasted peanuts
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Alzheimer Disease
Association Between Cerebral Arterial Vascular Flow and Sleep Apnea in Neurodegenerative Alterations
Obstructive sleep apnea syndrome (OSAS) is a sleep-disordered breathing characterized by the occurrence of repeated upper airway obstructions leading to airflow reduction (hypopnea) or cessation (apnea).
- Trial name
- VAAPS (NCT02578303)
- Testing
- Vascular flow measurement by PC-MRI
- Where
- France
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Central Hospital Saint Quentin
Stroke, Vascular Diseases
Passive Limb Movement Study
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance.
- Conditions
- Stroke, Vascular Diseases, Ischemic
- Trial name
- PLM (NCT05935670)
- Testing
- Ischemic Conditioning
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Healthy, Abnormal Vascular Flow
Racemic Ketamine Versus S-ketamine With Arterial Spin Labeling (ASL)-MRI in Healthy Volunteers
Racemic ketamine and S-ketamine are used in clinical practice today. Little is known of their difference in effect on cerebral blood flow, volume and metabolism.
- Trial name
- NCT01506921
- Testing
- Racemic ketamine, S-ketamine
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Lund University
Brain Insulin Sensitivity, Brain Vascular Function
High-Dairy Food Patterns and Gut-Brain Axis
Disturbances in brain insulin sensitivity are associated not only with obesity and type 2 diabetes, but also with brain aging and cognitive decline.
- Conditions
- Brain Insulin Sensitivity, Brain Vascular Function, Cerebral Blood Flow, Cognitive Performance
- Trial name
- NCT07355309
- Testing
- High-dairy food pattern, Low-dairy food pattern
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Blood Flow Velocity, Autoregulation
The Effect of an α2-Adrenoceptor Antagonist (Yohimbine) on Dynamic Autoregulation in the Human Middle Cerebral Artery and Ophthalmic Artery
Blood flow autoregulation is defined as the ability of a tissue to maintain a relatively constant flow, despite moderate alterations in perfusion pressure.
- Conditions
- Blood Flow Velocity, Autoregulation, Ocular Physiology
- Trial name
- NCT00814047
- Testing
- Yohimbine hydrochloride
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna