Clinical trials: Cerebral Circulatory Disorder
Stroke, Intracranial Stenosis
Characterizing Hemodynamic Compensation in Patients With Intracranial Stenosis
The overall aim of this work is to assess the relationship between stroke risk and hemodynamic compensation strategies, as measured using a novel 3.0 Tesla MRI protocol, in patients with symptomatic intracranial (IC)…
- Trial name
- VAMMPRIS (NCT02506907)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Vanderbilt University
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping…
- Trial name
- CORDMILK (NCT03657394)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Stroke, Hemiplegia
Visual and Auditory Electromyography Biofeedback Among Stroke Patients
Stroke commonly results in impairments of balance, mobility, and lower extremity motor function that limit independence in daily activities.
- Conditions
- Stroke, Hemiplegia, Stroke Rehabilitation
- Trial name
- NCT07710937
- Testing
- Visual Electromyography Biofeedback, Auditory Electromyography Biofeedback, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- University of Lahore
Brain Injuries, Stroke
Telerehabilitation in Severe Acquired Brain Injury
We will investigate the use of TR, based on advanced Information and Communication Technology (ICT) solutions, taking into account that the supervision of rehabilitation at home will be enriched with the counselling and vital…
- Trial name
- NCT03709875
- Testing
- TR Treatment
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Stroke, Paralysis Arm
PNS Motor Stimulation Study
Paralysis is one of the most disabling features of Spinal cord injury and stroke. In select cases, where the nerve is intact, stimulation can achieve meaningful muscle contraction e.g. to restore grip and release function.
- Conditions
- Stroke, Paralysis Arm, Spinal Cord Injury
- Trial name
- NCT07810712
- Testing
- Stimulation of the motor unit
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Walton Centre NHS Foundation Trust
Stroke, Self Efficacy
Visual Arts-based Intervention for Community-dwelling Stroke Survivors
Stroke is the major cause of disability worldwide and leads to psychosocial issues for community-dwelling stroke survivors in their recovery journey.
- Conditions
- Stroke, Self Efficacy, Psychosocial Problem
- Trial name
- NCT06395857
- Testing
- Visual arts-based intervention
- Where
- Macau
- Volunteers
- 32 people
- Sponsor
- The Nethersole School of Nursing
Stroke
Robotic Rehabilitation and Cognitive Functions
A recent multicenter study of the Fondazione Don Gnocchi (FDG) Robotic Rehabilitation Group (NCT02879279) showed the efficacy of robotic rehabilitation in upper limb motor recovery after stroke using a set of robots and…
- Trial name
- NCT04164381
- Testing
- Robotic assisted intervention
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Pulmonary Embolism
Home Treatment of Patients With Pulmonary Embolism Based on Pro-Brain Natriuretic Peptide (BNP) Levels
The aim of this study is to investigate the safety of treatment of pulmonary embolism in an outpatient setting based on normal pro-BNP levels.
- Trial name
- NCT00455819
- Testing
- home treatment
- Where
- 2 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Acute Ischemic Stroke
ANAIS Study to Confirm the Safety and Performance of the ANA 5F Advanced Neurovascular Access®
Prospective, single-arm, multi-center study to assess the safety and performance of the ANA 5F Advanced Neurovascular Access®, in combination with a stent retriever in patients with acute ischemic stroke.
- Trial name
- ANAIS (NCT05409430)
- Testing
- Neurothrombectomy
- Where
- 3 sites in Spain
- Volunteers
- 43 people
- Sponsor
- Anaconda Biomed S.L.
Delayed Cerebral Ischemia, Aneurysmal Subarachnoid Hemorrhage
Micro- and Macrovascular Parameters in Delayed Cerebral Ischemia
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) results from a complex combination of macro- and microvascular processes.
- Trial name
- PDMMS (NCT05483751)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Maastricht University Medical Center
Cerebral Atherosclerosis
Clinical Trial of Efficacy and Safety of Divaza for Adjustment of Oxidative Disorders in Patients With Cerebral Atherosclerosis
The purpose of this study is to obtain additional data on efficacy and safety of Divaza for adjustment of oxidative disorders in patients with cerebral atherosclerosis.
- Trial name
- NCT03485495
- Testing
- Divaza
- Where
- 10 sites in Russia
- Volunteers
- 124 people
- Sponsor
- Materia Medica Holding
Dementia
BOLD Functional Magnetic Resonance Imaging (fMRI) and Cerebral Blood Flow Measurements as Biomarkers for Cognition Enhancing Drugs (3134-006)
This study will evaluate functional magnetic resonance imaging (fMRI) and methods for measuring drug induced changes in cerebral blood flow as biomarkers for attention-improving drugs.
- Trial name
- NCT00887601
- Testing
- MK3134, Donepezil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cardiovascular Disease, Peripheral Arterial Disease
Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE
The primary aim is to assess the effects of raising HDL cholesterol (the good type) with extended release niacin/laropiprant 2g (previously known as MK-0524A) versus matching placebo on the risk of heart attack or coronary death…
- Conditions
- Cardiovascular Disease, Peripheral Arterial Disease, Diabetes Mellitus, Coronary Heart Disease
- Trial name
- HPS2-THRIVE (NCT00461630)
- Testing
- ER niacin/laropiprant, simvastatin, ezetimibe/simvastatin
- Where
- United Kingdom
- Volunteers
- 25,673 people
- Sponsor
- University of Oxford
Cerebrovascular Accident
Robotics For Rehabilitation Therapy: Functional Versus Individual Joint Training
The purpose of this study is to develop an upper extremity robotic training system for use by people with stroke to practice arm and hand movement in the clinic.
- Trial name
- NCT01050231
- Testing
- Functional/ Multi-joints activities, Individual Joint Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Intracerebral Hemorrhage
Deproteinised Calf Blood Serum Injection for the Treatment of Acute Intracerebral Hemorrhage
The purpose of this study is to investigate the efficacy and safety of Deproteinised Calf Blood Serum Injection in alleviating perihematomal edema (PHE) and secondary brain injury, as well as neurologic deficits in patients with…
- Trial name
- NCT03260153
- Testing
- Deproteinised Calf Blood Serum Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Resistive Training Combined With Nutritional Therapy After Stroke
Stroke survivors experience severe muscle wasting during the chronic phase of recovery, with implications for strength, function and general health.
- Trial name
- REPS (NCT02347995)
- Testing
- Protein
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Stroke, Acute Ischemic, Medium Vessel Occlusion
INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of IMP-ACT. Acute ischemic stroke (AIS) caused by intracranial arterial occlusion remains a major cause of disability and…
- Trial name
- IMP-ACT (NCT07906275)
- Testing
- Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre
- Where
- 4 sites in Canada
- Volunteers
- 800 people
- Sponsor
- University of Calgary
Aneurysm, Cerebral Aneurysm
Doppler Flow Wires in Cerebral Angiography
The purpose of this study is to use a wire with a Doppler tip to measure blood flow in vessels in the brain and determine hemodynamic factors associated with treatment success or failure.
- Trial name
- NCT03145701
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Washington
Paroxysmal Atrial Fibrillation, Cryptogenic Stroke
Smartwatch and External Holter Monitoring to Detect Atrial Fibrillation in Patients With Cryptogenic Stroke
Stroke recurrence largely depends on the detection of the cause and the control of vascular risk factors, with occult atrial fibrillation (AF) being one of the most important.
- Trial name
- SMARTTHUNDER (NCT05565781)
- Testing
- ECG smartwatch, Insertable Cardiac Monitor (ICM), External ECG Monitoring
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Ischemic Stroke, Intracranial Hemorrhages
Registry of Patients With Remote Posterior cErebral Hemorrhage Following Reperfusion Treatment in Ischemic Stroke
Introduction Remote cerebral hemorrhage following reperfusion treatment in ischemic stroke is rare (1.3-3.7% of all treated strokes) and is associated with worse functional and vital prognosis.
- Conditions
- Ischemic Stroke, Intracranial Hemorrhages, Hemorrhagic Transformation Stroke
- Trial name
- HEROES-CAT (NCT05871528)
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.