Clinical trials: Cerebral Circulatory Disorder, active
Stroke, Acute, Stroke, Ischemic
Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute/Subacute Phase (Month 1 to 4)
The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke, Subacute, Stroke Hemorrhagic
- Trial name
- EarlyExo (NCT06107010)
- Testing
- Use of the Atalante exoskeleton
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Wandercraft
Prediabetes, Brain Insulin Sensitivity
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with…
- Conditions
- Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake
- Trial name
- NCT07752225
- Testing
- Avocados
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht University Medical Center
Stroke, Chronic Stroke Patients
RESPARK - Brain Q for Chronic Stroke
This trial tests a promising new intervention to promote post-stroke neural reorganization and functional recovery. The Q Therapeutic (BQ 3.0) is a wearable medical system that produces and delivers non-invasive…
- Conditions
- Stroke, Chronic Stroke Patients, Cerebrovascular Accident (CVA)
- Trial name
- NCT07095920
- Testing
- Device: Q Therapeutic System (BQ 3.0) - Active
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Transcranial Bone Marrow Injection, RK-4
RK-4 Intracalvariosseous Injection in Treatment of Acute Large Hemispheric Infarction
An open-label, blinded Ib/IIa study investigating the treatment of acute large hemispheric infarction by transcranial bone marrow injection of RK-4 injection For subjects with acute large hemispheric infarction who are…
- Conditions
- Transcranial Bone Marrow Injection, RK-4, Acute Large Hemispheric Infarction, Acute Ischemic Stroke
- Trial name
- NCT07166380
- Testing
- RK-4 injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Carotid Artery Disease
SVS VQI TransCarotid Revascularization Surveillance Project
The VQI TCAR Surveillance Project is designed to monitor the safety and effectiveness of stents placed directly into the carotid artery while reversing blood flow within the carotid artery to reduce stroke risk.
- Trial name
- VQI-TCAR (NCT02850588)
- Testing
- Transcarotid artery revascularization, Carotid endarterectomy
- Where
- United States
- Volunteers
- 60,000 people
- Sponsor
- Society for Vascular Surgery Patient Safety Organization
Stroke
BurtVision™ for Arm Rehabilitation in Chronic Stroke Survivors:
The focus of this study is to perform a preliminary assessment of the efficacy of the BurtVision system. While the Burt robotic-arm assists the patient's upper-limb in their movements, BurtVision will allow the patient to perform…
- Trial name
- NCT04940403
- Testing
- Burt, Burt + BurtVision
- Volunteers
- 38 people
- Sponsor
- Spaulding Rehabilitation Hospital
Primary Prevention of Atherosclerotic Cardiovascular Disease
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c.) administered on Day 1, Day 90, and every 6 months thereafter in patients at…
- Trial name
- NCT05739383
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- 983 sites in United States, Argentina and 40 more
- Volunteers
- 14,012 people
- Sponsor
- Novartis Pharmaceuticals
Stroke (CVA) or TIA
Functional Electrical Stimulation Versus Whole-Body Vibration in Post-Stroke Rehabilitation
This study will compare the effects of Functional Electrical Stimulation (FES) and Whole Body Vibration Training (WBVT) on lower limb motor control, balance, and physical performance in post-stroke patients.
- Trial name
- NCT07629882
- Testing
- Functional Electrical Stimulation, Whole Body Vibration Training
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Stroke, Attention Disorder
Virtual-reality Exercises for Alleviating Attention Deficits in Patients With Acquired Brain Injury
Stroke is the leading cause of long-term disability with an increasing incidence, especially in young adults. Among the cognitive difficulties following brain damage, deficits in attention are frequent and pervasive, affecting…
- Trial name
- NCT05728840
- Testing
- Immersive virtual reality gamified cognitive activities, Double neuropsychological standard activities
- Where
- Switzerland
- Volunteers
- 135 people
- Sponsor
- Mindmaze SA
Stroke
Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence.
- Trial name
- CN-NINM (NCT06386510)
- Testing
- Strength training, Cranial nerve non-invasive neuromodulation
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- Université de Sherbrooke
Intracerebral Hemorrhage
Statins In Intracerbral Hemorrhage
The SATURN trial aims to determine whether continuation vs. discontinuation of statin drugs after spontaneous lobar intracerebral hemorrhage (ICH) is the best strategy; and whether the decision to continue/discontinue statins…
- Trial name
- SATURN (NCT03936361)
- Testing
- Statins
- Where
- United States
- Volunteers
- 1,456 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Ischemic Stroke
Recombinant Human Prourokinase for Acute Ischemic Stroke in the Extended Window Selected by CT-Based Artificial Intelligence
This multicenter, prospective, randomized, double-blind, placebo-controlled trial aims to evaluate the efficacy and safety of intravenous recombinant human prourokinase (rhPro-UK) in patients with acute ischemic stroke treated…
- Trial name
- RAISE-AI (NCT07901842)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK)
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Spinal Cord Injuries, Spinal Cord Injury Cervical
Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)
The ABT-TCSCS study investigates how feasible and beneficial are activity-based therapy and transcutaneous spinal cord stimulation on improving of arm and hand recovery after cervical spinal cord injury.
- Trial name
- ABT-TCSCS (NCT06472986)
- Testing
- Activity-based therapy and transcutaneous spinal cord stimulation
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Stroke
Study on the Incremental Predictive Value of Early Resting-State EEG Phenotypes for Functional Prognosis and Risk Stratification in Acute Ischemic Stroke
This is a single-center, prospective, observational cohort study that plans to consecutively enroll 400 patients with acute ischemic stroke from July 2026 to July 2029.
- Trial name
- NCT07741669
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Friedreich Ataxia, Cardiomyopathies
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy Adults
The goal of this clinical trial is to learn how ATI-105 administered to healthy participants at works in the body at different doses and with or without food.
- Conditions
- Friedreich Ataxia, Cardiomyopathies, Central Nervous System Diseases, Neuromuscular Diseases
- Trial name
- NCT07869654
- Testing
- ATI-105
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Adjuvia Therapeutics, Inc.
Adrenal Insufficiency, Polymyalgia Rheumatica
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency
In this double-blinded randomised placebo-controlled clinical trial, the aim is to determine the effect of supplemental hydrocortisone compared with placebo during mild to moderate physical or mental stress on health related…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica, Giant Cell Arteritis
- Trial name
- RESCUE (NCT05435781)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Marianne Christina Klose
Stroke, Disability Physical
Nurse-led Rehabilitation to Improve Self-care Among Stroke Patients in Bangladesh
Stroke causes various levels of disability, which decreases physical function for a prolonged period. The purpose of this study is to test the feasibility and efficacy of a nurse-led rehabilitation program focused on improving…
- Trial name
- NCT06786559
- Testing
- Assistive Device and health Education
- Volunteers
- 64 people
- Sponsor
- Hiroshima University
Orthostatic Hypotension
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases.
- Trial name
- NCT07309666
- Testing
- Intelligent diagnostic system for orthostatic hypotension
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Complications
An Epidemiological and Long-Term Endpoint Registry Study on Disease-Syndrome Correlation Patterns in Comorbid Population With Diabetes and Ischemic Cardio-Cerebrovascular Disease
Explore the characteristics of TCM syndrome elements and distribution patterns of syndrome types in comorbid populations; Screen for "high-risk syndrome patterns" and frequently co-occurring complex syndromes; Identify…
- Trial name
- Diabetes (NCT07104422)
- Volunteers
- 12,000 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Atrial Fibrillation (AF), Stroke
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
The aim is to investigate whether screening with long-term ECG monitoring in individuals with elevated NT-proBNP leads to a lower incidence of ischeamic stroke and death from vascular causes.
- Conditions
- Atrial Fibrillation (AF), Stroke, NT-pro-BNP, Cognitive Function and Well-Being
- Trial name
- PAFS-Tromsø (NCT07343895)
- Testing
- Long term heart rythm monitoring by ECG247
- Where
- 2 sites in Norway
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
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