Clinical trials: Cerebral Concussion
Traumatic Brain Injury, Injury of Body Region
Neuroimaging & Plasma Markers for Predicting Outcomes After Mild Traumatic Brain Injury
This exploratory study aims to identify the most promising biomarkers that alone or in combination might predict development of mood disorders [i.e., major depression (MD], cognitive disorders [i.e., executive function deficits…
- Trial name
- NCT02891941
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Concussion
Recent Experiences With Concussions
College athletes will be recruited to complete a voluntary online survey that will take approximately 10 minutes. In this survey, they will answer a series of questions related to the concussion symptoms they have experienced in…
- Trial name
- NCT02626650
- Testing
- Symptom elicitiation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Concussion, Mild Traumatic Brain Injury
Rehabilitation, Education, and SElf-management for Adolescents After Mild Traumatic Brain Injury
Concussion or mild traumatic brain injury (mTBI) is a major public health concern. Most adolescents will recover from mTBI without complication; however, a sizeable minority experience symptoms that last more than one most…
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Concussion
- Trial name
- RESET (NCT07698015)
- Testing
- Mindfulness-based intervention, Health Education
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Molly Cairncross
Concussion, Brain
Creatine Supplementation in Concussion Recovery
The proposed study aims to compare concussion recovery in those supplementing creatine and those not supplementing creatine. Specific aim 1: To compare number of days until asymptomatic between those taking creatine vs.
- Trial name
- CSCR (NCT06208813)
- Testing
- Creatine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- San Diego State University
Concussion (Diagnosis), Gait Abnormality
Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery
Approximately 1.6 to 3.8 million mild traumatic brain injuries, or concussions, occur yearly in the United States. Although most individuals progress through return-to-activity (RTA) using symptom-guided aerobic and functional…
- Trial name
- NCT07801482
- Testing
- Exercise, Return to Activity Progression
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Illinois University
Brain Concussion, Brain Injuries
An Evaluation of HS-1000 Device Capabilities in the Diagnosis and Assessment of Patients After Concussion
The HeadSense (HS) HS-1000 device, a new non-invasive brain monitor is expected to safely and accurately monitor concussed patients with minimal discomfort, potentially providing a new modality for concussion measurement.
- Trial name
- NCT02699346
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
Concussion (Diagnosis), Sport-related Concussion
Longitudinal Monitoring of Head Impacts in Elite Junior Ice Hockey
This study aims to better understand how head impacts during ice hockey affect the brain and body, especially in young athletes.
- Conditions
- Concussion (Diagnosis), Sport-related Concussion, Hockey Player
- Trial name
- DRAK-CARE (NCT07341880)
- Testing
- Head impact monitoring, Heart rate variability monitoring, Dual-task cognitive and motor assessment
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Brain Concussion, Traumatic Brain Injury
DANA Compared to MACE in Evaluation of Suspected Acute Concussion
The purpose of this study is to compare the sensitivity of the DANA Rapid exam with the MACE cognitive score. The primary hypothesis is that the DANA Rapid exam will be more sensitive for detecting impaired cognitive performance…
- Trial name
- NCT01728129
- Testing
- DANA Rapid, MACE
- Where
- Afghanistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Mild Traumatic Brain Injury
Enhancing Brain Training With Virtual Reality
The purpose of this study is to evaluate the effectiveness of brain training in a Virtual Reality set up in neurotypical populations as well as in the traumatic brain injury population.
- Trial name
- NCT03582579
- Testing
- Training in Virtual Reality, Training on a computer screen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Mild Traumatic Brain Injury
Deployment Related Mild Traumatic Brain Injury (mTBI)
The study will provide evidence on the long term outcomes of mTBI in service members returning from Afghanistan and Iraq. In addition, the study will provide evidence on mTBI incidence, and symptom patterns.
- Trial name
- NCT01847040
- Where
- 2 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Defense and Veterans Brain Injury Center
Brain Concussion, Mild Traumatic Brain Injury
Utilizing Electronic Clinical Decision Support to Enhance mTBI Care at the Primary Care Point of Entry
Six primary care practices within a large Philadelphia pediatric care network will use an electronic Clinical Decision Support (eCDS) tool as standard care for concussion evaluation.
- Trial name
- NCT06693778
- Testing
- electronic Clinical Decision Support tool for risk stratification of pediatric patients with mTBI
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Children's Hospital of Philadelphia
Concussion, Brain
Development of a Concussion Management Platform for Children and Youth
This multi-centred, randomized controlled trial will evaluate the effectiveness of a pilot tested mobile device Application built to guide youth in recovery from concussion.
- Trial name
- Back2PlayApp (NCT05471791)
- Testing
- Back2Play App
- Where
- 2 sites in Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- McMaster University
Brain Concussion, Post-Concussion Syndrome
Feasibility Testing of Cognitive Strategy Training in Post-Concussive Syndrome
This study will evaluate the practicality (i.e. acceptability to stakeholders; outcome battery feasibility; recruitment, retention, and adherence rates) and the preliminary effect of a cognitive strategy training intervention in…
- Trial name
- NCT04681742
- Testing
- CO-OP Group
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Brain Concussion
The s100β Levels in Patients With Mild Brain Injury.
Mild traumatic brain injury (TBI) accounts for the majority of TBI. At present, whether TBI has traumatic intracranial lession is mainly diagnosed by computed tomography (CT), while only 5% of mild TBI has positive CT results.
- Trial name
- NCT06131242
- Testing
- It is an observational study
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Sumei Lu
Mild Traumatic Brain Injury
HEAD Injury Serum Markers and Multi-modalities for Assessing Response to Trauma
The goal of HeadSMART II (HEAD injury Serum markers and Multi-modalities for Assessing Response to Trauma II) is to develop an In-Vitro Diagnostic, the BRAINBox TBI test, to aid in the diagnosis and prognosis of patients with…
- Trial name
- HeadSMART II (NCT04423198)
- Testing
- Cognitive Assessment, Patient Reported Neurological Outcome Assessments, Blood Draw
- Where
- 11 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- BRAINBox Solutions Inc
Sport Related Concussion
Pilot Study on the Correlation Between Accelerations Experienced
Concussion, or mild traumatic brain injury, accounts for 85% of brain injuries and is common in both professional and amateur sports.
- Trial name
- BIOIMPACT (NCT07507253)
- Testing
- Analyze correlations between the measurements of the variations in biomarkers with those obtained by an instrumented mouthguard measuring accelerations.
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sys2Diag
Concussion, Brain
Comparing and Interactive Concussion Education Platform to Current Education Standards
Purpose: The purpose of this study is to evaluate the effectiveness of a theory- driven education platform to improve concussion-related norms and perceptions in an effort to improve student-athletes concussion-related…
- Trial name
- NCT04122274
- Testing
- NCAA education sheet, Decision-based interactive concussive education platform
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Mild Traumatic Brain Injury, Concussion
Effect of Early Rest on Recovery From Pediatric Concussion
The purpose of this study is to find out if strict rest for 5 days helps children get better after concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Post-concussive Syndrome
- Trial name
- NCT01101724
- Testing
- Mandated Rest, Intervention
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical College of Wisconsin
Concussion, Headache
Sphenopalatine Ganglion Block for Headache After Concussion
This clinical trial will enroll participants to evaluate the effects of SPG block on post-traumatic headache. The study hypothesizes that patients that receive a SPG block with lidocaine vs.
- Trial name
- NCT04650282
- Testing
- Lidocaine in SphenoCath device, Saline Solution in SphenoCath device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Concussion, Brain, Mild Traumatic Brain Injury
EyeBOX Concussion Study and Registry
The objective of this study is to further evaluate eye movements as an aid in the diagnosis of concussion / mTBI and the utility of eye movement assessment in the monitoring of symptoms over time after an initial diagnosis of…
- Trial name
- NCT03966404
- Testing
- EyeBOX device
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oculogica, Inc.