Clinical trials: Cerebral Disorder
Parkinson's Disease, Gaucher's Disease
Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease
The investigators are interested in determining if the investigators are able to detect changes in brain chemistry using Magnetic Resonance Spectroscopy (MRS) in individuals with Parkinson's disease (PD), those with Gaucher's…
- Trial name
- NCT01427517
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cerebral Palsy
VIRTUAL REALITY TECHNOLOGY FOR CEREBRAL PALSY
The VRapeutic (Full-immersive game-based therapy) is new therapeutic Egyptian software. It has the potential to provide intensive, repetitive, and task-oriented training.
- Trial name
- NCT05872217
- Testing
- conventional upper extremity therapeutic program, full immersive VRapeutic software gaming technology
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Dementia, Infection, Bacterial
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias
This is a 52-month study (8 months preparation; 36 months to conduct the trial; 8 months data analyses and manuscript preparation) of a cluster randomized controlled trial (RCT) of an intervention to improve infection management…
- Trial name
- TRAIN-AD (NCT03244917)
- Testing
- TRAIN-AD
- Where
- United States
- Volunteers
- 430 people
- Sponsor
- Hebrew SeniorLife
Metastatic Malignant Neoplasm to the Adult Brain
Sector Irradiation Versus Whole Brain Irradiation for Brain Metastasis
Microneurosurgical resection of intracerebral metastases leads to prolonged survival and relief of symptoms in selected patients.
- Trial name
- NCT01667640
- Testing
- sector irradiation, whole brain irradiation
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University Innsbruck
Amyloid, Amyloid Cardiomyopathy
18F-florbetaben PET-CT to Non-invasively Diagnose Cardiac AL Amyloidosis
Amyloidoses are systemic or acquired disorders characterized by the deposition in the extracellular spaces of amyloid fibers formed by proteins codified by mutated genes or non-mutated but misfolded proteins.
- Trial name
- PETAL (NCT06048601)
- Testing
- 18F-florbetaben PET/CT
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Alzheimer Disease
A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability and efficacy of GV-971 in mild to moderate Alzheimer's disease.
- Trial name
- GREEN MEMORY (NCT04520412)
- Testing
- GV-971
- Where
- 171 sites in United States, Australia and 8 more
- Volunteers
- 2,046 people
- Sponsor
- Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
Suicidal Ideation, Major Depressive Disorder
Anti-suicidal Effects of Buprenorphine In Depressed Individuals
This study aims to examine the effect of low-dose buprenorphine as an add-on to treatment-as-usual for suicidal ideation in individuals with major depression, and investigate the functional brain activity related to its potential…
- Trial name
- NCT05427981
- Testing
- Belbuca Buccal Product
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Migraine Disorders
Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine
The investigators' study plans to randomize treatment naive patients with vestibular migraine to an 8 week trial of an escalating dose of either nortriptyline or topiramate followed by an 8 week crossover to the other drug if…
- Trial name
- NCT02169830
- Testing
- nortriptyline, Topiramate, Diet Modification
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- St. Louis University
Atrial Fibrillation (AF)
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly.
- Trial name
- ROXI-ATLAS (NCT07175428)
- Testing
- REGN7508, REGN9933, Apixaban
- Where
- 89 sites in United States, Argentina and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Regeneron Pharmaceuticals
Dementia, Stroke
Facilitating Caregiver Adaptation to Patient Institutionalization
This study will assess the effects of an intervention targeting family caregivers who recently placed a relative in a long-term care facility because of cognitive and/or physical disability.
- Conditions
- Dementia, Stroke, Heart Disease
- Trial name
- FACTS (NCT01194128)
- Testing
- Psychoeducational Support, Information only control group
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Hemiparesis, Stroke Sequelae
Neural Mechanisms of Motor Recovery With Technology Assisted Training
Stroke is a leading cause of disability that often impairs arm function and activities of daily living. The costs of rehabilitation are significant and practical constraints often limit therapy to the first few months after…
- Trial name
- NCT05560867
- Testing
- robot-assisted training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cerebral Aneurysm
Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity
After obtaining approval from the Institutional Review Board of our institution, written informed consent is obtained from patients undergoing interventional cerebral aneurysm coiling procedure are enrolled in this prospective…
- Trial name
- NCT02700607
- Testing
- Intravenous Crystalloid, Intravenous HES
- Volunteers
- 40 people
- Sponsor
- Konkuk University Medical Center
Acute Coronary Syndrome, Atrial Fibrillation
Short- and Long-term Health Effects of Air Pollution in Poland
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack…
- Conditions
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Particulate Matter Inhalation Injury
- Trial name
- EP-PARTICLES (NCT05198492)
- Testing
- Impact of air pollution
- Where
- Poland
- Volunteers
- 8,300,000 people
- Sponsor
- Medical University of Bialystok
Brain Injury Traumatic Severe (Diagnosis), Biomarkers
Biomarkers and Outcome 1 and 10-15 Years After Severe Traumatic Brain Injury
After written consent from next-of-kin patients with severe traumatic brain injury was included from the neurointensive care unit (NICU) at Sahlgrenska university hospital, Gothenburg.
- Trial name
- NCT05138692
- Where
- Sweden
- Volunteers
- 99 people
- Sponsor
- Bengt Nellgard
Atrial Fibrillation, Myocardial Infarction, Acute
Prognostic Role of LA Strain in Acute Myocardial Infarction
This is a single-center retrospective observational study in which we consecutively selected patients diagnosed with acute myocardial infarction from September 2019 to March 2024 at the Affiliated Hospital of Xuzhou Medical…
- Conditions
- Atrial Fibrillation, Myocardial Infarction, Acute, Stroke Ischemic, Mortality
- Trial name
- CMR-MI (NCT06408636)
- Testing
- Cardiac MRI
- Where
- China
- Volunteers
- 780 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Migraine
Oral Dexamethasone for Treatment of Migraine
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the emergency department (ED) [after successful treatment] prevents rebound headache.
- Trial name
- NCT00216736
- Testing
- Dexamethasone
- Where
- Australia
- Volunteers
- 63 people
- Sponsor
- The Joseph Epstein Centre for Emergency Medicine Research
Aneurysmal Subarachnoid Hemorrhage
Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients With Aneurysmal Subarachnoid Hemorrhage (HOMA)
This was a randomized, single-center trial. On the basis of standard-of-care, patients in the treatment group inhaled H2-O2 (66% hydrogen; 33% oxygen) at 3 L/min via nasal cannula by using the Hydrogen/Oxygen Generator (model…
- Trial name
- HOMA (NCT05282836)
- Testing
- Hydrogen Oxygen Generator with Nebulizer
- Volunteers
- 206 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Pain Due to Injury, Acute Pain
Evaluating the Impact of Focused Muscle Contraction Therapy in Retire APF Players
This study will investigate the effects of an exercise intervention on retired American professional football (APF) players. A total of 20 retired APF players (≥ 18 years of age), who suffer from chronic pain, will be enrolled.
- Conditions
- Chronic Pain Due to Injury, Acute Pain, Depression, Brain Injuries
- Trial name
- GH-APF (NCT04822311)
- Testing
- Experimental: Investigate the effects of an exercise intervention on retired APF players
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Illinois Chicago
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