Clinical trials: Cerebral Disorder
Amyotrophic Lateral Sclerosis
Investigation of Cannabinoid 2-receptor Expression in the Brain and Spine of ALS-patients Compared to Healthy Controls With PET (18F-RoSMALS)
This clinical trial is a phase 1 study in which investigations with the weakly radioactive substance [18F]-RoSMA-18-d6 are being carried out for the first time.
- Trial name
- 18F-RoSMALS (NCT05880563)
- Testing
- [18F]-RoSMA-18-d6
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Markus Weber
Guillain-Barré Syndrome, Miller Fisher Syndrome
International Guillain-Barré Syndrome Outcome Study
International GBS Outcome Study (IGOS) is a study conducted by the members of the Inflammatory Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS) on disease course and outcome in Guillain-Barré syndrome (GBS).
- Trial name
- IGOS (NCT01582763)
- Where
- 138 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people
- Sponsor
- Erasmus Medical Center
Oncolytic Virus, Diffuse Intrinsic Pontine Glioma
Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma
This is a single-arm, single-center, drug safety assessment clinical trial with a 3+3 dose escalation design, to observe the safety, tolerability and toxicity of a novel oncolytic virus Ad-TD-nsIL12 intratumoral injection in…
- Conditions
- Oncolytic Virus, Diffuse Intrinsic Pontine Glioma, Adverse Drug Event
- Trial name
- NCT05717699
- Testing
- Ad-TD-nsIL12
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University
Stroke, Rehabilitation
Stroke Rehabilitation Outcome During COVID-19 Lockdown
COVID-19 has a big impact on individuals and society as a whole. Especially persons with (multiple) comorbidities such as stroke are affected.
- Conditions
- Stroke, Rehabilitation, COVID-19, Cohort Studies
- Trial name
- SROCL (NCT04373109)
- Testing
- Observation
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Jeremia Held
Stroke, Multiple Sclerosis
Mobility Enhancing Nursing Intervention
Objectives: This parallel RCT investigated the effect of a new nursing intervention (Mobility Enhancing Nursing Intervention - MFP) designed to improve the rehabilitation programs' outcomes and patients' quality of life.
- Trial name
- MFP (NCT02198599)
- Testing
- Mobility-enhancing-nursing intervention
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- Zurich University of Applied Sciences
Hypertension, Cerebral Small Vessel Diseases
Songling Xuemaikang Capsules for Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) is a common age-related microvascular disease related to the slow accumulation of damage to small arteries, veins, and capillaries.
- Trial name
- SXC-CSVD (NCT07271732)
- Testing
- Songling Xuemaikang Capsule
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Dongzhimen Hospital, Beijing
Amblyopia, Visual Training
A Randomized Controlled Trial of Autostereoscopic 3D Vision Therapy for Amblyopia
The goal of this clinical trial is to learn if an autostereoscopic 3D amblyopia training system works to improve vision in children and adolescents with amblyopia.
- Conditions
- Amblyopia, Visual Training, Visual Functions, Visual Health
- Trial name
- NCT07709832
- Testing
- Autostereoscopic 3D Training, Conventional Patching
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Beijing Tongren Hospital
Pantothenate Kinase-Associated Neurodegeneration
CoA-Z in Pantothenate Kinase-associated Neurodegeneration (PKAN)
The purpose of this study is to learn more about how people with the condition pantothenate kinase-associated neurodegeneration (PKAN) respond to a specialized study product.
- Trial name
- NCT04182763
- Testing
- CoA-Z
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Oregon Health and Science University
Pompe Disease (Late-onset)
Evaluation of the Safety, Tolerability and Efficacy of Gene Therapy Drug for Late Onset Pompe Disease (LOPD)
This is a single-center, single-arm, open-label, single-dose treatment clinical study to evaluate the safety, tolerability and efficacy of CRG003 injection in participants with late onset Pompe disease (LOPD), with a long-term…
- Trial name
- NCT06178432
- Testing
- CRG003 injection
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Huashan Hospital
Alzheimer Disease, Dementia
Tele-Savvy for Latino Caregivers
Latino caregivers of individuals with Alzheimer's disease and related dementias experience high levels of stress burden and depressive symptoms and are underrepresented in caregiver intervention research.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Stress
- Trial name
- NCT07290387
- Testing
- Tele Savvy for Latino Caregivers
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Rochester
Parkinson's Disease
Non-invasive Measurement of Brain Oxygen Levels in People With Subthalamic Deep Brain Stimulators
The purpose of this study is to determine if deep brain stimulation can change brain oxygen levels in people with Parkinson's Disease.
- Trial name
- NCT02278406
- Testing
- Deep brain stimulator
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Beth Israel Deaconess Medical Center
Dementia With Lewy Bodies
Study To Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies
This study will be conducted to compare Irsenontrine to placebo on the cognitive endpoint of Montreal Cognitive Assessment (MoCA) and the global clinical endpoint of Clinician's Interview Based Impression of Change Plus…
- Trial name
- NCT03467152
- Testing
- Irsenontrine
- Where
- 74 sites in United States, France and 5 more
- Volunteers
- 326 people
- Sponsor
- Eisai Inc.
Stroke
Effects of Touch Massage in the Sub-acute Phase After Stroke
The aim is to study effects of touch massage in the sub-acute phase after stroke in two main areas; general health and independence.The hypothesis are that; touch massage in the sub-acute phase after stroke decreases anxiety and…
- Trial name
- MEST (NCT01883947)
- Testing
- Touch massage, non-TENS
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Umeå University
Giant Cell Arteritis, Temporal Arteritis
Ustekinumab for the Treatment of Giant Cell Arteritis
The purpose of this study is to determine whether ustekinumab is effective in the treatment of Giant Cell Arteritis (GCA)
- Conditions
- Giant Cell Arteritis, Temporal Arteritis, Horton's Disease
- Trial name
- UGCA (NCT02955147)
- Testing
- Ustekinumab, Prednisone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Cerebrovascular Disorders, Deglutition Disorders
Stroke Swallowing Screening Tool Validation
Stroke is a major medical problem in the United States, and veterans are at significant risk given that the most critical risk factors of stroke, older age and associated medical problems such as high blood pressure, are common.
- Trial name
- SSST (NCT01559649)
- Testing
- Establishing Validity and Reliability
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Depression, Dementia
Home-delivered Intervention for Depressed, Cognitively Impaired Elders
Among older adults the combination of depression, cognitive impairment (memory problems), and disability contribute to a worsening of physical and mental health and to poor treatment outcomes.
- Conditions
- Depression, Dementia, Geriatrics
- Trial name
- NCT01350349
- Testing
- Problem Adaptation Therapy (PATH), Supportive Therapy
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes Mellitus Type 2, Hypercholesterolemia
Effect of Ezetimibe or Simvastatin or Both on Low Densitiy Lipoprotein -Subfractions in Patients With Type 2 Diabetes
It is of interest how ezetimibe alone or in combination with statin may influence atherogenic dense Low Density Lipoprotein (dLDL) in patients with type 2 diabetes mellitus.
- Trial name
- EZE (NCT01384058)
- Testing
- ezetimibe, simvastatin, Ezetimibe 10/Simvastatin 20
- Where
- 2 sites in Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Brain Neoplasm
18F-FET PET in Childhood Brain Tumours
FET PET 2010 is a prospective, multicentre trial aiming to evaluate the additional benefit of FET PET in the assessment of remission after first line therapy and during follow-up
- Trial name
- NCT03216148
- Testing
- FET-PET
- Where
- 22 sites in Germany
- Volunteers
- 160 people
- Sponsor
- Charite University, Berlin, Germany
Stroke
A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke
PRISMS is a double-blind, multicenter, randomized, Phase IIIb study to evaluate the efficacy and safety of intravenous (IV) alteplase in participants with mild acute ischemic strokes that do not appear to be clearly disabling.
- Trial name
- PRISMS (NCT02072226)
- Testing
- Alteplase, Aspirin
- Where
- 88 sites in United States
- Volunteers
- 313 people
- Sponsor
- Genentech, Inc.
Epilepsy
Comparison of Oral Brivaracetam Versus Levetiracetam as Monotherapy in Epilepsy
Despite increasing clinical use of both agents, there is a paucity of head-to-head comparative data on the safety and efficacy of brivaracetam versus levetiracetam as initial monotherapy in children.
- Trial name
- NCT07163585
- Testing
- Brivaracetam, Levetiracetam
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- RESnTEC, Institute of Research
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