Clinical trials: Cerebral Disorder
Stroke, Sarcopenia
Evaluating and Monitoring Physical Fatigue While Performing Functional Activities
Fatigue is a critical health parameter in older adults and stroke patients and is associated with negative health outcomes. Current assessment tools predominantly focus on walking related fatigue, neglecting other activities of…
- Conditions
- Stroke, Sarcopenia, Fatigue
- Trial name
- NCT06513377
- Testing
- Performance test
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Cerebral Palsy, Gait
FES to Improve Crouch Gait in CP
The overall goal of the proposed work is to develop and to assess the feasibility of using functional electrical stimulation (FES) system to improve crouch gait in individuals with cerebral palsy that may prevent the typical…
- Trial name
- CP FES Walking (NCT04209257)
- Testing
- Functional Electrical Stimulation.
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Dwarfism, Growth Hormone Deficiency
Drug Use Investigation of Somatropin for GHD-ADULTS.
Post marketing drug use investigation of Genotropin for GHD-ADULTS.
- Trial name
- NCT00601419
- Testing
- Somatropin
- Volunteers
- 230 people
- Sponsor
- Pfizer
Obesity
Effects of Macronutrient Diet on Brain Activity
This study will evaluate the effect of macronutrient diets on brain activity in homeostatic and mesolimbic reward regions.
- Trial name
- NCT02300857
- Testing
- Low carbohydrate diet, Moderate carbohydrate diet, High carbohydrate diet
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obesity
Involvement of the Gut Microbiota-brain Cross-talk in the Loss of Eating Control
Overweight and obesity are increasingly prevalent worldwide. These bodyweight disorders are closely related to deficiencies in the control of food intake.
- Trial name
- GMBTalk-Food (NCT05646901)
- Where
- Spain
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Dementia With Lewy Bodies, REM Sleep Behavior Disorder
Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)
This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia…
- Conditions
- Dementia With Lewy Bodies, REM Sleep Behavior Disorder, Parkinson's Disease Dementia
- Trial name
- NCT02708186
- Testing
- Nelotanserin
- Where
- 23 sites in United States
- Volunteers
- 34 people
- Sponsor
- Axovant Sciences Ltd.
Japanese Encephalitis
Long Term Persistence and Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51
The study investigates the long term persistence the Japanese encephalitis vaccine IC51 and the need of a booster dose
- Trial name
- NCT00595270
- Testing
- IC51
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Traumatic Brain Injury
Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension
Objective: to assess the effectiveness of pentobarbital and thiopental to control raised intracranial pressure (ICP), refractory to first level measures, in patients with severe traumatic brain injury.
- Trial name
- NCT00622570
- Testing
- Pentobarbital, thiopental
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Universitari Son Dureta
Migraine
A Study to Evaluate the Efficacy and Safety of Eptinezumab Administered Intravenously in Participants Experiencing Acute Attack of Migraine
The purpose of this study is to evaluate the efficacy and safety of eptinezumab administered intravenously in participants experiencing an acute attack of migraine.
- Trial name
- RELIEF (NCT04152083)
- Testing
- Eptinezumab
- Where
- 57 sites in United States, Georgia
- Volunteers
- 485 people
- Sponsor
- H. Lundbeck A/S
Parkinson Disease
Pharmacokinetic Profile of BIA 6-512 in Healthy Elderly Subjects Versus Healthy Young Subjects
the purpose of the study was to the compare pharmacokinetic profile of BIA 6-512 in healthy elderly subjects versus healthy young subjects after single and repeated oral administration of 200 mg BIA 6-512.
- Trial name
- NCT03095105
- Testing
- 200 mg BIA 6-512
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Ischemic Stroke
Managing Aftercare for Stroke (MAS): MAS-I - a Cross Sectional Study of Post-rehabilitation Stroke Burden and Patients' Needs
In this first step of the study the investigators will assess the needs, disease burden and current treatments of long-term stroke patients (phase MAS-I).
- Trial name
- MAS-I (NCT02320994)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Charite University, Berlin, Germany
Atrial Fibrillation, Stroke
Evaluation of 5 Days Holter and 30 Days Thumb-ECG for Detection of Atrial Fibrillation in Stroke Patients
This study will compare the two methods 5 days holtermonitoring and 30 days thumb electrocardiogram for detection of atrial fibrillation in stroke patients
- Trial name
- EHOT (NCT02261766)
- Testing
- Holter monitoring and Thumb ECG
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Herlev Hospital
Migraine Disorders
Optimized tDCS for the Treatment of Migraine
The aim of this study is to establish an optimized protocol of tDCS that normalize the lack of habituation and efficiency of inhibitory cortical circuits in migraine patients and determine tDCS polarity and the best cortical…
- Trial name
- NCT02562222
- Testing
- anodal tDCS on M1, cathodal tDCS on M1, anodal tDCS on V1
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Epilepsy, Epilepsy; Seizure
Impact of Self-visualization of Epileptic Seizures on Patients' Perception of the Disease and Risk Behavior
In Spain, an estimated 690,000 persons have epilepsy, of whom 270,000 have active epilepsy (defined as those who have had a seizure in the last 5 years).
- Conditions
- Epilepsy, Epilepsy; Seizure, Risk Behavior, Risk-Taking
- Trial name
- VICE (NCT04311151)
- Testing
- own seizures visualization
- Volunteers
- 200 people
- Sponsor
- Parc de Salut Mar
Sturge - Weber Syndrome (SWS)
Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)
Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face.
- Trial name
- NCT00610402
- Testing
- blood sample tear drop sample
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, Irvine
Alcohol Dependence
Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism
The overarching aim of this trial is to evaluate naltrexone's efficacy in light of genetic variation and brain response to alcohol cues utilizing a neuroimaging paradigm. This trial has four specific aims.
- Trial name
- NCT00920829
- Testing
- Naltrexone 50 Mg
- Where
- 2 sites in United States
- Volunteers
- 358 people
- Sponsor
- Medical University of South Carolina
Migraine Disorders
Tai Chi for the Prophylaxis of Episodic Migraine: the Efficacy Examination and Mechanism Exploration
The proposed study aims to examine the clinical efficacy of 24-week Tai Chi training in the prophylaxis of episodic migraine comparing with standard prophylactic medication in Hong Kong Chinese women, and to explore the mechanism…
- Trial name
- NCT05690737
- Testing
- Tai Chi training, Standard prophylactic medication
- Where
- 2 sites in Hong Kong
- Volunteers
- 220 people
- Sponsor
- The Hong Kong Polytechnic University
Glioblastoma, Newly Diagnosed Glioblastoma
REMIND Maintenance Radiotherapy for Newly Diagnosed Glioblastoma
REMIND is a single-center feasibility study testing maintenance radiotherapy in adult patients with newly diagnosed glioblastoma.
- Conditions
- Glioblastoma, Newly Diagnosed Glioblastoma, Brain Tumor
- Trial name
- REMIND (NCT07831772)
- Testing
- Maintenance Radiotherapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Hypoxia-Ischemia, Brain, Signs and Symptoms
Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study
The brain is such a metabolically active organ that it consumes about 20% of oxygen burned every minute by an average adult even though it only contributes about 2% of the body weight.
- Trial name
- DOSI (NCT01483495)
- Testing
- Diffuse optical spectroscopy
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of California, Irvine
Parkinson Disease, Impulse Control Disorders
Behavioural Addiction and Genetics in Parkinson's Disease
The " Behavioural Addiction and Genetics in Parkinson's Disease " study (BADGE-PD) is a national (France), multicenter, genetic association, case-control study to identify genetic factors associated with behavioural addiction (or…
- Trial name
- BADGE-PD (NCT02319395)
- Testing
- Blood Sampling and DNA collection
- Where
- France
- Volunteers
- 332 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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