Clinical trials: Cerebral Disorder
Alzheimer Disease, Cognition Disorders
Registry of Amyloid Positive Patients for Alzheimer's Disease Drug Research Trials
This registry will be used to identify patients who have etiology diagnosed or suspected to be Alzheimer's disease and positive amyloid scans, and have indicated their interest in being contacted for an Eli Lilly and Company…
- Trial name
- RAmP (NCT02918539)
- Testing
- florbetapir F 18 PET scan
- Where
- 75 sites in United States
- Volunteers
- 317 people
- Sponsor
- Avid Radiopharmaceuticals
Disability Physical, Brain Injuries
Impact of Custom Assistive and Adaptive Technology in Rehabilitation
Madonna's Rehabilitation Engineering Center of Excellence (REC) is continually developing custom devices for persons with disabilities.
- Conditions
- Disability Physical, Brain Injuries, Stroke, Spinal Cord Injuries
- Trial name
- NCT03567239
- Testing
- Using adaptive device.
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Madonna Rehabilitation Hospital
Traumatic Brain Injury, Word Finding Difficulty
Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will…
- Conditions
- Traumatic Brain Injury, Word Finding Difficulty, Acquired Brain Injury, Cognitive Change
- Trial name
- NCT05408975
- Testing
- Active Transcranial direct current stimulation
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas at Dallas
Necrotizing Enterocolitis, Digestive System Abnormalities
Brain Manganese Deposition in High Risk Neonates
Excessive exposure to manganese (Mn) results in Mn deposition in the brain causing adverse neurological effects. Sick infants requiring parenteral nutrition (PN) may be at increased risk of Mn neurotoxicity because neonatal PN…
- Conditions
- Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392977
- Testing
- remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Vanderbilt University
Brain Metastases, Radiotherapy
FSRT Combined With TMZ for Large BMs: a PSM Study
A propensity- matched study was conducted to investigate the feasibility and safety of adding temozolomide to hypofractionated stereotactic radiotherapy for large brain metastases.
- Conditions
- Brain Metastases, Radiotherapy, Chemotherapy
- Trial name
- NCT03338075
- Testing
- fractionated stereotactic radiotherapy
- Volunteers
- 72 people
- Sponsor
- Chinese Academy of Medical Sciences
Traumatic Brain Injury, Coagulation Disorder
The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders
The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders.
- Trial name
- NCT04274777
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Cerebral Palsy
Effects of Myofascial Release Technique on Upper Limb Functions in Cerebral Palsy
Cerebral palsy (CP) is a common neurodevelopmental disorder characterized by motor impairments, including spasticity, muscle tightness, and limited range of motion in the limbs.
- Trial name
- NCT06198101
- Testing
- Myofascial Release Technique, Myofascial Release Technique along with segmental vibrator
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Pain, Chronic Pain
Developing rTMS Treatment Strategies for Pain in Opiate Dependence
The purpose of this study is to parametically evaluate two different types of repetitive Transcranial Magnetic Stimulation (rTMS) treatment strategies as a potential treatment for pain in individuals currently taking prescription…
- Conditions
- Pain, Chronic Pain, Opioid Dependence, Opioid Use
- Trial name
- NCT03576781
- Testing
- Real iTBS, Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Perceptions of Burden in Patients With Late-Stage Cancer and Their Caregivers
RATIONALE: Gathering information over time about patients' sense of being a burden on their caregiver, and caregivers' sense of burden on themselves, may help doctors learn more about the desire to die in patients with late-stage…
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Depression, Leukemia
- Trial name
- NCT00770419
- Testing
- medical chart review, questionnaire administration, psychosocial assessment and care
- Sponsor
- Rutgers, The State University of New Jersey
Brain Injuries
Examining the Experiences of Brain Injury Patients in Medical Trials
Historically, participation in clinical trials has been skewed towards certain groups. However, research on the factors that influence participation, both positive and negative, is limited.
- Trial name
- NCT05690919
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Parkinson Disease
Attending to External Cues and Movement Strategies in Parkinson Disease
People with Parkinson's disease use compensatory strategies to overcome typical gait disturbances. These strategies rely on attentional mechanisms, however people with Parkinson disease suffer of decline in cognitive function.
- Trial name
- NCT04674319
- Testing
- external cues and cogntive movement strategies
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Galit Yogev-Seligmann
Fabry Disease, Lysosomal Storage Diseases
A Long Term Follow-Up Study of Fabry Disease Subjects Treated With FLT190
Fabry disease is a rare, X-linked inborn error of glycosphingolipid metabolism caused by an abnormal gene encoding the α-galactosidase A (αGLA) enzyme.
- Trial name
- NCT04455230
- Testing
- FLT190
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 3 people
- Sponsor
- Spur Therapeutics
Multiple Sclerosis, Stroke
Lakeshore Examination of Activity and Disability Exercise Response Study
This study will examine the effectiveness of two types of group exercise classes on the health and functional status in inactive adults age 18-65 with neurological conditions including Multiple Sclerosis, stroke, and spinal cord…
- Trial name
- LEADERS (NCT02533882)
- Testing
- Movement to Music, Adapted Yoga
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Alabama at Birmingham
Dystonia, Focal Hand Dystonia
Transcranial Electrical Polarization to Treat Focal Hand Dystonia
This study will evaluate the effect of transcranial electrical polarization (TEP), also called direct current (DC) stimulation, on focal hand dystonia in people with writer's cramp.
- Conditions
- Dystonia, Focal Hand Dystonia, FHD
- Trial name
- NCT00106782
- Testing
- Transcranial Electrical Polarization (TEP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pain, Inflammatory
An Imaging Study to Investigate the Distribution of GW842166X in the Brain.
GW842166X is being developed for the treatment and management of inflammatory pain. GW842166X is a CB2 receptor agonist and the mechanism is not fully understood, although it is thought that for the anti-inflammatory action the…
- Trial name
- NCT00511524
- Testing
- GW842166X, [carbonyl-^11C]GW842166
- Where
- Sweden
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cerebrovascular Accident, Depression
Sertraline for Preventing Post-stroke Depression and Improving Rehabilitation Outcomes
This study will determine the effectiveness of sertraline administration after a stroke in preventing the onset of post-stroke depression.
- Trial name
- NCT00177424
- Testing
- sertraline
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- University of Pittsburgh
Migraine, Headache
Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine
The purpose of this study is to determine whether a fixed-dose combination of naratriptan + naproxen is effective compared each monotherapy for the acute treatment of migraine.
- Trial name
- Atenéia (NCT01390324)
- Testing
- Fixed-dose combination of naratriptan+naproxen, Naratriptan, Naproxen
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Acute Ischemic Stroke
Flow Arrest Safety and Technical Success With Balloon Guide Catheters
The objective of this post-market registry is to assess technical efficacy and safety associated with the use of the BOSS Balloon Guide Catheter during neuro-vascular procedures while providing temporary arrest of blood flow.
- Trial name
- FAST-BGC (NCT04416659)
- Testing
- Neuro-vascular access
- Where
- 9 sites in United States
- Volunteers
- 52 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Acromegaly
Long Term Use of Somavert (Pegvisomant) For A Regulatory Post Marketing Commitment Plan
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors…
- Trial name
- NCT00658879
- Testing
- Somavert (Pegvisomant)
- Volunteers
- 251 people
- Sponsor
- Pfizer
Alzheimer's Disease
Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid
The number of Americans diagnosed with Alzheimer's disease (AD) is expected to triple by 2050. Compared to the general population, Veterans have a greater risk of AD, likely in part due to their increased incidence of traumatic…
- Trial name
- BRAVE-EPA (NCT02719327)
- Testing
- icosapent ethyl (IPE)
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
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