Clinical trials: Cerebral Glucose Metabolism
Healthy, Vasodilation
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
- Conditions
- Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction
- Trial name
- NCT05153395
- Testing
- Carbon dioxide breathing, Neurovascular Coupling, Human insulin
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations.
- Trial name
- NCT04328337
- Testing
- Intralipid, 20% Intravenous Emulsion
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Abnormalities, Arterial Blood Pressure
Multicenter Study on Cardiovascular and Metabolic Complications in Patients With Biochemically Silent Pheochromocytomas and Paragangliomas
The aim of the study is to characterise the cardiovascular and metabolic complications pre- and post-surgery of patients with biochemically negative PPGL and to compare them with normal individuals and patients with secreting…
- Conditions
- Cardiovascular Abnormalities, Arterial Blood Pressure, Heart Rate, Congestive Heart Failure Chronic
- Trial name
- NCT07316075
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Hypoglycemia
Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes
The purpose of this study is to investigate how the brain responds to low blood glucose in non-diabetic individuals. The ultimate goal is to understand the brain substrates of hypoglycemia unawareness, a condition that can occur…
- Trial name
- NCT02866435
- Testing
- Insulin, Glucose, Potassium phosphate
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes, Senile Dementia, Alzheimer Type
A Study of Mobile Medical Supportive Care Program for Family Caregivers With Dementia Combined With Diabetes
The purpose of this project is to evaluate the effectiveness of the clinical application of a mHealth supportive care program for family caregivers with dementia combined with diabetes based on the supportive care framework.
- Trial name
- NCT06785857
- Testing
- mHealth Supportive Care Program, Offline supportive care
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuanjiao Yan
Type 2 Diabetes, Stroke
The Effect of GLP-1 on Glucose Uptake in the Brain and Heart in Healthy Men
Type 2 diabetes mellitus, T2D is a disease characterized by an immense growing prevalence world wide with an increased risk of myocardial infarction and stroke.
- Conditions
- Type 2 Diabetes, Stroke, Myocardial Infarction
- Trial name
- NCT00256256
- Testing
- glucagon-like-peptide-1
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Metabolic Syndrome, Coronary Artery Disease
Brain, Cardiac Hemodynamics and Cognition During Exercise in Subjects With Various Cardiovascular Profiles
People with cardiovascular risk (CV) factors (obesity, diabetes, etc...) or established heart disease (such as coronary heart disease or chronic heart failure) often have cognitive dysfunction as compared to people without CV…
- Conditions
- Metabolic Syndrome, Coronary Artery Disease, Heart Failure
- Trial name
- COGNEX (NCT03018561)
- Testing
- Exercise and Cognitive testing
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Atherosclerotic Plaque, Diabetes Mellitus, Type 2
Pakistan Study of Premature Coronary Atherosclerosis in Young Adults
Coronary heart disease (CHD) is a major cause of morbidity, disability, mortality, and health expenditures worldwide. A wealth of studies has demonstrated that people of South Asian ancestry have a higher risk of CHD and…
- Conditions
- Atherosclerotic Plaque, Diabetes Mellitus, Type 2, Hypertension, Stroke
- Trial name
- PAKSEHAT (NCT05156736)
- Where
- Pakistan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tabba Heart Institute
Type 1 Diabetes, Hypoglycemia
Brain Ketone Metabolism in Type 1 Diabetes
This study is designed to examine the value of infusing BHB in type 1 diabetic subjects during experimentally induced hypoglycemic episode in conjunction with testing of cognitive function.
- Trial name
- NCT02471040
- Testing
- Beta-hydroxybutyrate, Normal Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Yale University
Pre Diabetes
Assessment of the Impact of a Personalised Nutrition Intervention in Impaired Glucose Regulation
This study will determine if DNA-based dietary guidelines can improve glucose regulation in pre-diabetic individuals significantly more than standard dietary guidelines following 6 weeks of the intervention.
- Trial name
- ASPIRE-DNA (NCT03702465)
- Testing
- DNA-based dietary intervention, DNA-based dietary intervention using an app, Control arm
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive
The Effect of Aromatherapy Massage on Pain, Anxiety and Comfort
Patients in the intensive care unit (ICU) experience physical and psychological discomfort, including pain. Anxiety is a condition frequently encountered in the ICU.
- Conditions
- Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive, Diabetes Mellitus, Type 2, High Blood Pressure
- Trial name
- NCT06295874
- Testing
- Effect of aromatherapy massage on vital signs, pain, anxiety and comfort level
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nilgün Erdoğan
Fabry Disease, Healthy
PET Scans in Normal Volunteers and Patients With Fabry Disease
This study will determine the rate of sugar metabolism in the brain of patients with Fabry disease, a genetic disease of abnormal lipid metabolism.
- Trial name
- NCT00005111
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Diabetes Mellitus, Type 1
Biological Sample Collection for Research and Biobanking
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells).
- Conditions
- Parkinson Disease, Diabetes Mellitus, Type 1, Macular Degeneration, ALS
- Trial name
- NCT04270604
- Testing
- Biological sample collection
- Where
- United States
- Volunteers
- 1,279 people, healthy volunteers welcome
- Sponsor
- New York Stem Cell Foundation Research Institute
Coronary Heart Disease, Stroke
Evaluating Tools for Health Promotion and Disease Prevention
The study will evaluate the effect of familial risk assessment and prevention prompts tailored to familial risk on health behaviors and use of preventive services among adults who are members of primary care practices in the U.S.
- Conditions
- Coronary Heart Disease, Stroke, Diabetes, Breast Cancer
- Trial name
- NCT00164658
- Testing
- Familial risk assessment and personalized prevention messages
- Where
- 3 sites in United States
- Volunteers
- 8,400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Insulin Resistance, Transcranial Direct Current Stimulation
Improving Insulin Sensitivity by Non-invasive Brain Stimulation
Efforts in curing and preventing obesity and type 2 diabetes (T2D) have been elusive thus far. One reason for that is the lack of understanding of the role of the brain in the development and treatment of the disease.
- Conditions
- Insulin Resistance, Transcranial Direct Current Stimulation, Obesity, Diabetes
- Trial name
- NCT04420650
- Testing
- transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Abdominal Obesity, Cardiovascular Diseases
Grain Exercise Trial - Whole Grain Versus no Grain With or Without Physiotherapy-promoted Exercise for Waist Loss
The main purpose of this 2-year lifestyle experiment for waist loss is twofold: 1. to compare whole grains and no grains as part of a healthy diet, 2.
- Conditions
- Abdominal Obesity, Cardiovascular Diseases, Diabetes Type 2, Hypertension
- Trial name
- GET (NCT01208558)
- Testing
- Diet A, Diet B, Physiotherapy
- Where
- Sweden
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Lund University
Alzheimer Disease (AD), Cardio Vascular Disease
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA).
- Conditions
- Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
- Trial name
- ALOHA (NCT07180147)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marymount University
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Glioma
Assessing Brain Metabolism Using MRS With Deuterated Glucose
This study will investigate the use of Hydrogen 1 (1H) magnetic resonance spectroscopy (MRS) with deuterated glucose (2H-glucose) to detect dynamic glucose uptake in the brain.
- Trial name
- NCT06594315
- Testing
- Deuterated Glucose, Magnetic Resonance Imaging (MRI), Blood Sample
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco