Clinical trials: Cerebral Saturation
COVID-19, Respiratory Failure
Effects of Cardiovascular and Pulmonary Optimization on Cerebral Oxygenation in COVID-19 Patients With Severe ARDS
The aim of the present study is to examine whether cerebral oxygenation could be a more useful parameter than peripheral oxygen saturation to guide clinical titration of permissive hypoxemia in COVID-19 ARDS patients
- Trial name
- NIRS-COV (NCT04392089)
- Testing
- Masimo, LidCO
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Oxygen Deficiency
Validation of Next Generation Cerebral and Tissue Oximeter
This is a validation study of a near-infrared spectroscopy (NIRS) device designed to measure the cerebral tissue oxygen saturation.
- Trial name
- NCT03128372
- Testing
- Desaturation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Baro-reflex Sensitivity, Heart Rate Variability
Low Intensity Exercise in Different Normobaric/Hypobaric Normoxic/Hypoxic Conditions.
The main goal of this project is to investigate how low intensity cycling exercise (1.5W/kg, for 6 minutes) influences cerebral functions, such as: Cerebral blood flow, oxygenation, and other physiological variables in different…
- Conditions
- Baro-reflex Sensitivity, Heart Rate Variability, EEG, Microstates, Cerebral Blood Flow Regulation
- Trial name
- Hypoxia (NCT03439202)
- Testing
- Hypoxia
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fliegerärztliches Institut
Aortic Stenosis Disease, TAVI(Transcatheter Aortic Valve Implantation)
Cerebral Regional Oxygen Saturation During TAVI - The CROS-TAVI Prospective Registry
This single-center, non-commercial clinical study investigates how different types of transcatheter aortic valve prostheses affect cerebral oxygen saturation during the procedure (TAVI - Transcatheter Aortic Valve Implantation).
- Conditions
- Aortic Stenosis Disease, TAVI(Transcatheter Aortic Valve Implantation), Cerebral Oxygen Saturation, Hemodynamic Changes
- Trial name
- CROS-TAVI (NCT07016789)
- Testing
- Near-infrared spectroscopy monitoring (NIRS) INVOS 5100C
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cognitive Dysfunction, Postoperative Complications
The Effect of Hypotensive Anesthesia on Cognitive Functions in Orthognatic Surgery
The purpose of this study is to evaluate the effects of maintaining adequate cerebral oxygen saturation on patients undergoing orthognathic surgery.
- Trial name
- NCT06925711
- Testing
- Near-Infrared Spectroscopy (NIRS)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medipol University
Delirium, Dementia, Amnestic, Cognitive Disorders, Arthroplasty, Hip Replacement
Cerebral Regional Oxygen Saturation and Markers of Brain Damage During Primary Hip Arthroplasty
Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear.
- Trial name
- NCT02342236
- Testing
- cemented or cementless type of hip prothesis
- Where
- Poland
- Volunteers
- 18 people
- Sponsor
- Military Institute od Medicine National Research Institute
Impaired Oxygen Delivery, Critically Ill Patient
Non-Invasive Measurement of SjvO2 Using Near Infrared Spectroscopy in Critically Ill Patients
ScvO2 is an important parameter in the management of critically ill patient. The only way to measure it is to have an internal jugular or subclavian central venous catheter.
- Trial name
- NIRS-SCJVO2 (NCT04624009)
- Where
- 2 sites in Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Ischemic Attack, Transient
Does Positioning Effects on Early Postoperative Cognitive Dysfunction in Laparoscopic Oncological Surgery
Laparoscopic surgery is an alternative to open surgical techniques for reasons such as less blood loss,less need for transfusion, shorter discharge time.
- Trial name
- NCT04714346
- Testing
- no interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Elderly Patients Undergoing Spinal Surgery
Post-operative Cognitive Dysfunction and the Change of Regional Cerebral Oxygen Saturation in Elderly Patients Undergoing Spinal Surgery
Post operative cognitive dysfunction (POCD) is a well-recognized complication of patients undergoing cardiac surgery. Previous studies reported near-infrared spectroscopy provides information on the occurrence of cerebral…
- Trial name
- NCT01839227
- Testing
- Neurologic and neuropsychologic tests
- Where
- South Korea
- Volunteers
- 87 people
- Sponsor
- Yonsei University
Hypotension Drug-Induced, Cerebral Oxygen Saturation
Effect of Controlled Hypotension on Cerebral Oxygen Saturation
For a successful functional endoscopic sinus surgery (FESS), it is crucial to provide effective controlled hypotension to reduce blood loss and provide a relatively blood-free surgical environment to facilitate surgery.
- Trial name
- NCT02967029
- Testing
- Esmolol Hydrochloride, Remifentanil Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Cardiac Surgical Procedures, High-risk Surgical Patient
A New Non-invasive Marker to Detect Silent Hypoxia in Patients Undergoing Cardiac Surgery
In patients undergoing cardiac surgery under cardiopulmonary bypass, some organs like brain and heart are preserved while others (skin, gut and skeletal muscle) are being underperfused.
- Conditions
- Cardiac Surgical Procedures, High-risk Surgical Patient, Anaerobic Threshold
- Trial name
- NCT01560611
- Testing
- Near infrared spectroscopy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Depression
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
This is a randomized controlled study assessing the effect of pre-emptive hyperventilation on ECT seizure duration, cerebral desaturation and remission of depressive symptoms in patients with Major Depressive Disorder.
- Trial name
- NCT02924090
- Testing
- Etomidate, Ketamine, Hyperventilation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Cardiovascular Diseases, Postoperative Complications
Effects of Cerebral Oxygen Saturation on Neuropsychological Outcomes
The purpose of this study is to evaluate the effects of maintaining adequate cerebral oxygen saturation (over 40%) on patients undergoing cardiac surgery.
- Trial name
- NCT00151307
- Testing
- INVOS cerebral oximeter
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Cataract Extraction, Anesthesia, Local
Cerebral Oxymeter and End Tidal Carbondioxide Values Under Surgical Drapes With and Without Past COVID-19 Infection
Today, phacoemulsification has become the most commonly applied method in the treatment of cataract, which is considered as a public health problem.
- Conditions
- Cataract Extraction, Anesthesia, Local, Optic Nerve Sheath
- Trial name
- NCT05571683
- Testing
- oxygen support
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Duzce University
Parkinson Disease
Retinal Biomarkers in Parkinson´s Disease
The goal of this observational study is to determine whether oxygen content of the retinal vessels of the eye may serve as a biomarker in Parkinson´s disease. The main questions it aims to answer are: 1.
- Trial name
- NCT06929026
- Where
- Iceland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Landspitali University Hospital
Electrical Cardioversion of Atrial Fibrillation, Pharmacological Cardioversion of Atrial Fibrillation
Cerebral Oxygen Saturation Measurement During Cardioversion Because of Atrial Fibrillation
Near infrared spectroscopy (NIRS) is a technique that measures regional cerebral oxygenation in a non-invasive manner. Through the use of near infrared light, the difference between oxygenated and deoxygenated hemoglobin can be…
- Trial name
- NCT02378155
- Testing
- SenSmart Model X-100, Nonin Medical
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Hasselt University
Regional Cerebral Oxygen Saturation
Effect of Different Positive End Expiratory Pressures on Regional Cerebral Oxygen Saturation
The goal of this prospective single-blind randomized clinical trial is to compare the effect of two different positive end expiratory pressure (PEEP) levels on regional cerebral oxygen saturation in patients scheduled for…
- Trial name
- NCT05961917
- Testing
- 5 cmH2O Positive end-expiratory pressure (PEEP), 10 cmH2O Positive end-expiratory pressure (PEEP)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bozyaka Training and Research Hospital
Elective Off-pump Coronary Artery Bypass Grafting
Relation Between Mixed Venous Oxygen Saturation and Cerebral Oxygen Saturation Measured by Absolute and Relative Near-infrared Spectroscopy During Off-pump Coronary Artery Bypass Grafting.
In this clinical study the investigators compared mixed venous oxygen saturation (SmvO2) with relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Trial name
- NCT01673841
- Testing
- Relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Ghent
Cerebral Oxygenation
Effect of Left Paratracheal Pressure on Cerebral Oxygenation During General Anesthesia
Left paratracheal pressure (LPP) has been proposed as an alternative to cricoid pressure to reduce the risk of regurgitation during induction of general anesthesia.
- Trial name
- PARANIRS (NCT07778303)
- Testing
- Left Paratracheal Pressure, Cricoid Pressure
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Clinique Saint-Luc
Congenital Heart Disease, Infant, Premature, Diseases
The Research of the Effect of Sevoflurane on Brain-protection of Cardiac Surgery in Infants.
To observe the effect of sevoflurane on the concentration of S100β and regional cerebral oxygen saturation in infants with congenital heart disease undergoing cardiac surgery.
- Trial name
- NCT03366597
- Testing
- Sevoflurane
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jun Ma