Clinical trials: Cerebrospinal; Disorder
Alzheimer's Disease
Single Photon Emission Computed Tomography (SPECT) Imaging Study to Develop a Biomarker for Alzheimer's Disease
The main objectives of this proposal are as follows: To assess the dynamic uptake and washout of 123-I MNI-388 and MNI 390, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed…
- Trial name
- NCT00886951
- Testing
- I123MNI388/I123MNI390
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Mild Traumatic Brain Injury
BRAINI-2 Elderly Mild TBI European Study
Mild traumatic brain injury (mTBI) is one of the most frequent emergencies in the elderly population. Despite most mTBI are managed with cranial computed tomography (CT), only 10% of CTs show lesions, determining CT overuse.
- Trial name
- BRAINI2ELDER (NCT05425251)
- Testing
- GFAP and UCH-L1
- Where
- 7 sites in France, Germany and 1 more
- Volunteers
- 2,297 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario 12 de Octubre
Mild Cognitive Impairment, Alzheimer Disease
Retinal Neuro-vascular Coupling in Patients With Neurodegenerative Disease
Alzheimer´s disease (AD) in one of the most important causes of dementia and poses a considerable challenge in health care. Today, criteria for the diagnosis and the follow up of patients with AD mainly rely either on subjective…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Healthy
- Trial name
- NCT02663531
- Testing
- DVA, FDOCT, Pattern ERG
- Where
- Austria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Apathy, Alzheimer's Disease
Treatment of Apathy in Alzheimer's Disease With Modafinil
This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs) and caregiver burden in individuals with Alzheimer's disease (AD).
- Trial name
- NCT01172145
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brown University
Encephalitis
Safety and Immunogenicity of the Japanese Encephalitis Vaccine IC51 (IXIARO®) in a Pediatric Population
The primary objective is to assess the systemic and local safety profile of purified inactivated Japanese Encephalitis Virus (JEV) vaccine IC51 administered in two doses in a 28 days interval up to Month 7 after the first IC51…
- Trial name
- NCT01041573
- Testing
- IC51 Japanese Encephalitis, Havrix®720, Prevnar
- Where
- 2 sites in Philippines
- Volunteers
- 1,869 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Parkinson Disease, Parkinson Disease Dementia
Monoamine Oxidase B PET/CT in Various MAO-B-Related Disease
To evaluate the potential usefulness of 18F-FPyCO/SMBT-1 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various MAO-B-related disease patients.
- Conditions
- Parkinson Disease, Parkinson Disease Dementia, Parkinson's Disease and Parkinsonism
- Trial name
- NCT07685873
- Testing
- Diagnostic Test: 18F-FPyCO/SMBT-1
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease, Freezing of Gait
The Electrophysiological Investigation of Higher Level Neural Manifestations of Freezing of Gait in Parkinson's Disease Patient
We aim to investigate the higher level mechanism of gait disorders in PD patients by ambulatory recording of electroencephalographic (EEG) and leg electromyographic (EMG) signals during unconstrained walking.
- Trial name
- NCT02214251
- Testing
- PK-16CH EXG system
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Parkinson Disease
Earlier Diagnosis and Better Treatment Mission Related to the Cohort Programme
The Luxembourg Parkinson's Study is an ongoing longitudinal nationwide monocentric observational study. It collects extensive clinical, molecular, genetic, and digital device-based longitudinal data, as well as foreseen…
- Trial name
- LuxPARK (NCT05266872)
- Testing
- Observational study with sample and data collection
- Where
- 2 sites in Luxembourg
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Alzheimer's Disease, Dementia
iCare Stress Management e-Training for Dementia Family Caregivers
Photozig and Stanford University are creating a program to help cope with caregiving, alleviate related stress, and enhance quality of life for caregivers, with funding from the National Institute on Aging.
- Trial name
- iCare (NCT01378195)
- Testing
- CBT-based program for dementia caregivers, Educational/Resources program
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Photozig, Inc.
Traumatic Brain Injury
Developing Therapies for Traumatic Brain Injury
Background: A person who has a traumatic brain injury (TBI) -- also called concussion -- can have serious and long-lasting effects.
- Trial name
- NCT01420939
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Concussion
Interactive Training in Sports Concussion Prevention and Management
This study evaluated Brain 101: The Concussion Play book, an intervention that provides education and resources on concussion management for high schools.
- Trial name
- NCT01978795
- Testing
- Brain 101 website, Control
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Frailty Syndrome, COVID-19
Implementation of the Integrated Care of Older People App and ICOPE Monitor in Primary Care (ICOPE)
Introduction: The World Health Organization has launched the INSPIRE-ICOPE-CARE program towards healthy aging. It includes "intrinsic capacity", defined as "the composite of all the physical and mental capacities of an…
- Conditions
- Frailty Syndrome, COVID-19, Healthy Aging, Old Age; Debility
- Trial name
- ICOPE (NCT04413877)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Liege
Traumatic Brain Injury, Concussion, Brain
Treatment Comparison for Undergraduate College Students With Traumatic Brain Injury
Up to 28% of undergraduate college students report a suspected history of traumatic brain injury. Following traumatic brain injury, college students fail and repeat more courses and have lower grade point averages.
- Trial name
- NCT04628741
- Testing
- Dynamic Coaching Model, Apprenticeship Approach
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Brain Diseases, Hypertension
Clinical Indicators and Brain Image Data: a Study Based on Kailuan Cohort
The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a…
- Trial name
- NCT05453877
- Testing
- No intervention will be applied.
- Where
- 2 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Healthy Subjects
Study Evaluating The Coadministration of Begacestat And Donepezil
This study examines the cardiac effects (effects on the heart) of administering donepezil and begacestat together to healthy subjects.
- Trial name
- NCT00959881
- Testing
- Donepezil, Begacestat
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Neoplasms, Glandular and Epithelial, Diphtheria
Concomitant Use of Gardasil (V501, Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) With Combined Diptheria, Tetanus, Pertussis and Poliomyelitis Vaccine in Adolescents (V501-024)(COMPLETED)
Data from this study are expected to demonstrate that Gardasil (V501, Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine), when administered concomitantly with a combined diphtheria, tetanus, pertussis, and…
- Conditions
- Neoplasms, Glandular and Epithelial, Diphtheria, Tetanus, Whooping Cough
- Trial name
- NCT00337428
- Testing
- Comparator: Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant (qHPV) Vaccine from Current Manufacturing Facility (CMF), Comparator: Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant (qHPV) Vaccine from Future Manufacturing Facility (FMF), Comparator: REPEVAX™ (Concomitant)
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Spinal Cord Injuries, Cardiovascular Diseases
Role of Endothelial Function in SCI CVD Risk
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT06443151
- Testing
- Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid), venous occlusion plethysmography, Acetylcholine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Visual Impairment, Amblyopia
Developing Better Computerised Vision Tests (CVTV)
Clinical vision measurements usually involve printed charts with an eye care professional interpreting patient responses to generate a score. Those scores determine the need for or outcome of treatment.
- Conditions
- Visual Impairment, Amblyopia, Macular Degeneration, Ophthalmic Disease
- Trial name
- CVTV (NCT06224751)
- Testing
- Near logMAR letter acuity, Near LogMAR word acuity, Red Green Stereoacuity
- Where
- United Kingdom
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Spinal Cord Injury
Investigating Kinematic and Electromyographic Changes After SCI and Their Relation to Clinical and Functional Outcome
The study aims at discerning specific gait patterns and elucidating locomotor control of spinal cord injured patients in order to find sensitive kinematic and electromyographic outcome measures that are able to reveal information…
- Trial name
- NCT02150629
- Where
- Switzerland
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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