Clinical trials: Cerebrovascular Circulation
Multiple Sclerosis
The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients
This study will determine whether sildenafil citrate, commonly known as Viagra, can cause increased blood flow to the brain in a wide range of multiple sclerosis (MS) patients, including women.
- Trial name
- NCT00094068
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Headache, Migraine
Natriuretic Peptide's Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of the natriuretic peptides.
- Trial name
- NCT01637662
- Testing
- Natriuretic peptides
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Iron, Cerebral Blood Flow
16 Weeks' Dietary Supplementation With Iron and Iron + Vitamin C on Cerebral Blood Flow and Energy Expenditure in Women of Reproductive Age
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Conditions
- Iron, Cerebral Blood Flow, Energy Metabolism, Cognitive Function
- Trial name
- NCT04477018
- Testing
- Iron bis-glycinate chelate and vitamin C, Iron bis-glycinate chelate
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healthy, Mood Disorders
Effects of Drugs on Cerebral Blood Flow in Patients With Mood Disorders
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Trial name
- NCT00001478
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cerebrovascular Circulation
Blood Brain Flow and Exercise
Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults.
- Trial name
- NCT02653638
- Testing
- Control, Indomethacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Metabolic Syndrome X
Mechanisms of Cerebrovascular Control
The objective of this study is to identify insulin-specific cerebral blood flow (CBF) control mechanisms, and establish cerebrovascular responsive baseline in younger (18-45 yrs) metabolic syndrome adults (MetSyn) who are at…
- Trial name
- NCT02936687
- Testing
- NOS Inhibition, ET-1 Inhibition, 3 Tesla MRI
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Regional Anesthesia, Horner Syndrome
Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block
The purpose of this study is to assess cerebral blood flow velocity (CBFV) following regional anesthesia for shoulder surgery. The results of this study will help to further understand the physiologic effect of the interscalene…
- Conditions
- Regional Anesthesia, Horner Syndrome, Cerebral Blood Flow
- Trial name
- CBF-TCD (NCT04642612)
- Testing
- TCD Measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Healthy Adults
Acute Effects of Sitting and Physical Activity on Brain Health
The specific aim of this study is to understand how a working day composed of prolonged sitting, sitting regularly interrupted by light aerobic exercise or resistance exercise affects an important mechanism underpinning healthy…
- Trial name
- NCT04137211
- Testing
- Prolonged sitting with social break, Prolonged sitting with walk break, Prolonged sitting with simple resistance activities
- Where
- Sweden
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Gestational Diabetes Mellitus (GDM), Postpartum Women
The Impact of Gestational Diabetes Mellitus on Cerebral Blood Flow and Cerebrovascular Function After Pregnancy
Gestational Diabetes Mellitus (GDM) currently affects approximately 14% of all pregnancies worldwide. Importantly, the health-related consequences of GDM extend well beyond pregnancy, such that women with a history of GDM have a…
- Conditions
- Gestational Diabetes Mellitus (GDM), Postpartum Women, Uncomplicated Pregnancy
- Trial name
- NCT06911372
- Testing
- Intradermal Microdialysis, Brain Blood Flow Tests, Local Heating
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Blood Pressure
The Effect of Whey Protein Supplementation on Vascular and Cognitive Function in Older Adults
The "hardening of the arteries" observed with aging raises blood pressure and contributes to poor brain blood flow and loss of cognitive function (i.e. attention, memory, solving problems, making decisions).
- Trial name
- NCT01956994
- Testing
- Whey protein supplement, Carbohydrate supplement
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Brain Vascular Function, Cerebral Blood Flow
Effects of Peanut Consumption on Brain Function
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Brain Insulin Sensitivity, Cognitive Performance
- Trial name
- NCT05724654
- Testing
- Skin roasted peanuts
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Brain Vascular Function, Cognition
NWT-03 and Brain Function
Age-related chronic diseases including dementia, type II diabetes mellitus (T2DM) and cardiovascular disease (CVD) become more prevalent and of increasing societal concern.
- Trial name
- NCT04831203
- Testing
- An egg-protein hydrolysate (NWT-03)
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Brain Concussion, Post-Concussion Syndrome
Cerebral Blood Flow Regulation and Concussions
The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
- Trial name
- NCT02754206
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Healthy
Effect of Garlic Extracts on Changes in Cerebral Blood Flow
The purpose of this study is to assess the safety and efficacy of Garlic extracts for improving of cerebral blood flow.
- Trial name
- NCT05349253
- Testing
- Garlic extracts
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Cardiovascular Diseases
Cardiac Rehab and Cerebral Blood Flow Study
This study is being done to better understand the influence of cardiovascular disease on brain blood flow regulation and cognitive function, determine whether exercise-based cardiac rehabilitation can lead to better regulation of…
- Trial name
- NCT05012878
- Testing
- Cardiac rehabilitation - high intensity interval training (HIIT), Cardiac rehabilitation - moderate intensity continuous training (MICT), Cardiac rehabilitation - control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 1 Diabetes, Hypoglycemia Unawareness
Naltrexone and Hypoglycemia in Type 1 Diabetes
Low blood sugar is also called hypoglycemia. Usually, it is mild and can be treated quickly and easily by eating or drinking a small amount of a sugar-rich food.
- Trial name
- Naltrexone (NCT01053078)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Polycystic Ovary Syndrome, Exercise
The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
This study will investigate the impact of high- and moderate-intensity exercise on the cardiometabolic and brain health of women with Polycystic Ovary syndrome (PCOS).
- Conditions
- Polycystic Ovary Syndrome, Exercise, Cerebrovascular Circulation
- Trial name
- NCT05394935
- Testing
- High-Intensity Exercise, Moderate-Intensity Exercise
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cardiff Metropolitan University
Cerebral Small Vessel Diseases
Recovery Improved in Covert Stroke With Exercise
Silent ischemic, also known as "covert stroke vascular disease" (CSVD), contributes to neurological deficits that are caused by damage to small blood vessels in the brain.
- Trial name
- RISE-2 (NCT02068391)
- Testing
- Stretching Program, Exercise Program
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre