Clinical trials: Cerebrovascular Circulation
Cerebral Blood Flow, Brain Function
Effects of Acetate and Alcohol on Brain Function
This study plans to learn more about how alcohol and its metabolite, acetate, affect the brain.
- Trial name
- NCT02542150
- Testing
- acetate, alcohol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cerebrovascular Circulation, Affect
The Effect of Tea Breaks on Cerebrovascular Perfusion During Desk Work
Sedentary behaviour of healthy subjects may have a detrimental impact on cerebral blood flow as well as cognitive measures related to mood and alertness.
- Trial name
- NCT03953391
- Testing
- Tea, Water
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Obstructive Sleep Apnea (OSA)
Heart and Brain Blood Flow in Obstructive Sleep Apnea
Obstructive sleep apnea causes repeated pauses in breathing during sleep. Breathing efforts against an occluded airway may change how blood flows through the heart and how blood drains from the brain.
- Trial name
- OSA4DFlow (NCT07913269)
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy Male Subjects
Effect of Sodium Nitroprusside on Cerebral Blood Flow
The brain has a high energy demand and requires continuous blood flow. The blood flow to the brain appears to be unaffected by small changes in blood pressure, but brain blood flow may be reduced by a large reduction in blood…
- Trial name
- NCT03317652
- Testing
- Hyperventilation, 6% CO2 breathing, Infusion of sodium nitroprusside
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Major Depressive Disorder
Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
The specific focus of this study is to gather data regarding the effects of a psychological therapy known as Problem Solving Therapy (PST) on cerebral blood flow (CBF), cortical gray matter (GM) atrophy, subcortical white matter…
- Trial name
- PRS (NCT02440815)
- Testing
- Problem Solving Therapy
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cognitive Change
Transcranial Near-Infrared Light in Healthy Subjects: a Cerebral Blood Flow Study With Diffuse Correlation Spectroscopy
Transcranial Light Therapy involves non-invasive and invisible beams of light that increase energy metabolism in the brain. Transcranial light therapy has been found to promote brain metabolism.
- Trial name
- NIR-Flow (NCT03740152)
- Testing
- Transcranial Light Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Vascular Dementia, Subcortical Vascular Dementia
Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity
The purpose of this study is to determine whether Zydena (Udenafil) has effect on cerebral blood flow and peripheral blood viscosity in normal and subcortical vascular cognitive impairment subjects.
- Trial name
- SMCZN01 (NCT01466543)
- Testing
- Zydena (Udenafil)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Stroke, Healthy Participants
Prefrontal Brain Activity and ECG Patterns in Stroke and Healthy Adults
This observational study will evaluate brain activity and heart rhythm patterns in people with and without stroke. Brain activity will be measured using functional near-infrared spectroscopy (fNIRS) and electroencephalography…
- Trial name
- NCT07322107
- Where
- South Korea
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Effects of; Movement, Inactivity, Physical
Effects of Ping-Shuai-Gong and Arm-Swing-Exercise
Ping Shuai Gong (PSG) and Arm Swing Exercise (ASE) are two similar exercise with different arm-swinging strategies. This study is plan to explore the relationship between characteristics of arm-swinging movement and skin blood…
- Conditions
- Effects of; Movement, Inactivity, Physical, Degeneration
- Trial name
- NCT05343897
- Testing
- Low intensity exercise - Ping-Shuai Gong (PSG), Low intensity exercise - Arm-Swing Exercise (ASE)
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Multiple Sclerosis, Relapse
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
This is a multi-center, prospective, controlled study. MS patients (1° group: 30 patients in relapse; 2° group: 30 patients in remission) and age/sex-matched healthy controls (3° group: 30 subjects) will be enrolled in the study.
- Trial name
- NCT04380220
- Testing
- Blood samples and processing
- Where
- 3 sites in United States, Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Headache, Migraine
Natriuretic Peptide's Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of the natriuretic peptides.
- Trial name
- NCT01637662
- Testing
- Natriuretic peptides
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Cognitive Change
Acute Dose-ranging Effects of Mango Leaf Extract (Zynamite® 15%) on Cognitive Function and Cerebral Blood Flow
Zynamite® is a novel mango (Mangifera indica) leaf extract standardized to contain polyphenol mangiferin.It has previously been shown to enhance brain oxygenation, physical performance and ergogenic parameters following…
- Trial name
- NCT05580146
- Testing
- Zynamite® 15% 150mg, Zynamite® 15% 300mg, Zynamite® 15% 600mg
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Alcohol Consumption, Cerebral Blood Flow
Kudzu Effects on Brain Ethanol Levels: Proton Spectroscopy Assessment
This study is designed to test whether treatment with kudzu extract will increase the rate at which alcohol enters the brain as measured by rapid proton magnetic resonance spectroscopy (1H-MRS).
- Trial name
- Kudzu MRS (NCT01739842)
- Testing
- Kudzu extract
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cardiovascular System
Effects of Caffeine on Cerebral Blood Flow
The goal of this clinical trial is to evaluate in clinically healthy young people if: after caffeine ingestion, there are variations in blood velocity of the middle cerebral arteries (VMCA), this variation is dependent on the…
- Trial name
- NCT05866848
- Testing
- Anhydrous caffeine (45mg), Anhydrous caffeine (120mg)
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde de Coimbra
Subarachnoid Hemorrhage, Aneurysmal
Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
- Trial name
- NCT04938414
- Testing
- Lumbar puncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebrovascular Disorders
Identification of microRNAs Involved in Cerebral Collateral Regulation
Patients >18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will…
- Trial name
- microRNA (NCT03905434)
- Testing
- miRNA sampling
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Mild Cognitive Impairment, Cerebral Blood Flow
A Study of Low-level Light Therapy Using Photo-activated Modulation Ameliorates Cognitive Deficits
The primary objective of this study is to confirm and compare the effect of methods of Low-level light therapy (LED-T) in the mild cognitive impairment.
- Conditions
- Mild Cognitive Impairment, Cerebral Blood Flow, Low-level Light Therapy, Brain Activity
- Trial name
- NCT03192670
- Testing
- Low-level light therapy device
- Where
- 2 sites in South Korea
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Yong-il Shin, MD
Metabolic Syndrome
Human Cerebrovascular Blood Flow and Sex Differences in Metabolic Syndrome
This study tests the hypothesis that Metabolic Syndrome (MetSyn) decreases cerebral blood flow (CBF) more in females than males due in part to the sex-specific loss of COX vasodilation.
- Trial name
- NCT07218653
- Testing
- Indomethacin, MRI
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aging Well
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
This study will analyze the influence of acute bout exercise intensities (continuous moderate and HIIT) on middle cerebral artery velocity (MCAv) to identify which intensity elicits the greatest increase in CBF in older adults…
- Trial name
- NCT05131217
- Testing
- Acute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, Control
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cognitive Function, Mood
The Effects of Caffeine and L-theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood
Although the beneficial effects of caffeine on cognition and mood have been reported in a number of studies, relatively few studies have looked at the effects of caffeine in combination with other phytonutrients despite the fact…
- Trial name
- NCT00981955
- Testing
- Caffeine and L-theanine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University