Clinical trials: Cerebrovascular Diseases
Cerebral Infarction, Thrombolysis
Early Low-dose ASpirin Use After Intravenous Thrombolysis for Acute Ischemic Cerebral Infarction（ELASTIC）
This study evaluates whether early administration of low-dose aspirin (100mg) at 2 hours post-intravenous thrombolysis, compared to the standard timing of 24 hours, improves functional outcomes in patients with acute ischemic…
- Trial name
- ELASTIC (NCT07563673)
- Testing
- Aspirin (Early, 2h), Aspirin (Standard, 24h)
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Chao Yang Hospital
Pseudobulbar Affect (PBA), Stroke
Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)
The objectives of the study are to evaluate the safety, tolerability, and effectiveness of NUEDEXTA capsules containing 20 mg DM (Dextromethorphan)/10 mg Q (Quinidine) for treatment of Pseudobulbar Affect (PBA) in patients with…
- Conditions
- Pseudobulbar Affect (PBA), Stroke, Dementia, Traumatic Brain Injury (TBI)
- Trial name
- PRISM II (NCT01799941)
- Testing
- Nuedexta (DM 20 mg/Q 10 mg)
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Avanir Pharmaceuticals
Stroke
Adaptive Sports for Individuals With a Physical Disability : Effect Among Stroke Survivors
The objective of the study is to evaluate the effect of engaging in adaptive sports for individuals who have had a stroke. The study is cross-sectional, participants with stroke will be recruited and divided into two groups: the…
- Trial name
- APSA-AVC (NCT05443529)
- Testing
- Adaptive sports
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Giant Cell Arteritis
An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA)
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of tocilizumab in participants with GCA.
- Trial name
- NCT01791153
- Testing
- Tocilizumab, Prednisone, Corticosteroids
- Where
- 78 sites in United States, Belgium and 12 more
- Volunteers
- 251 people
- Sponsor
- Hoffmann-La Roche
Stroke
Comparison of Two High-intensity Gait Training Interventions on Contraversive Pushing Behaviors in Individuals Poststroke
The purpose of this study is to investigate the effect of two high-intensity gait training interventions on contraversive pushing behaviors in individuals poststroke in the acute inpatient rehabilitation setting.
- Trial name
- NCT04550039
- Testing
- Body-weight-supported treadmill, Ekso Bionics EksoNR exoskeleton
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Ischemic Stroke, Acute, Blood Pressure Variability
Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic Stroke
This prospective observational cohort study examines whether blood pressure variability and nighttime blood pressure patterns, measured non-invasively over 72 hours with a cuffless ring-type wearable device, help predict recovery…
- Conditions
- Ischemic Stroke, Acute, Blood Pressure Variability, Cerebral Small Vessel Disease, White Matter Hyperintensity
- Trial name
- COMPASS (NCT07903922)
- Testing
- Cuffless ring-type continuous blood pressure monitor
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Minyoul Baik
Cardiac Surgery With Cardiopulmonary Bypass, Atrial Fibrillation
Left Atrial Appendage Occlusion Study III
Atrial fibrillation (AF) is a common heart rhythm disorder that leads to one-sixth of all strokes. Prevention of strokes in AF is achieved through the use of blood thinners such as coumadin.
- Trial name
- LAAOS III (NCT01561651)
- Testing
- Left Atrial Appendage Occlusion
- Where
- Canada
- Volunteers
- 4,812 people
- Sponsor
- Population Health Research Institute
Stroke
Left Atrial Function in Recurrent Stroke of Unknown Cause
Stroke is an important cause of disability and the third leading cause of death. Approximately 30 to 40 % of all strokes are estimated to be cryptogenic (i.e. no cause can be found).
- Trial name
- NCT02968329
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Hasselt University
Acute Ischemic Stroke
Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in Acute Ischemic Stroke
This is a Phase I/II, randomized, double-blind, placebo-controlled, single/multiple ascending dose clinical study (Investigator-Initiated Trial, IIT) evaluating the safety and efficacy of Human Adipose-Derived Stem Cell Exosomes…
- Trial name
- NCT07398612
- Testing
- Human Adipose-Derived Stem Cell Exosomes
- Volunteers
- 60 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Stroke, Chest Wall Disorder
Addition of Proprioceptive Neuromuscular Facilitation to Cardio Respiratory Training Post Stroke
Post-stroke hemiparesis causes sequelae in the limbs and also in the trunk and abdomen structures. The level of physical activity decreases and cardiorespiratory training(CRT) is indicated to this population to improve the…
- Conditions
- Stroke, Chest Wall Disorder, Quality of Life
- Trial name
- NCT03171012
- Testing
- Lower limbs CRT, Upper limbs CRT, Proprioceptive Neuromuscular Facilitation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Ischemic Stroke
Differentiating Between Brain Hemorrhage and Contrast
The goal of this observational study is to use artificial intelligence to differentiate cerebral hemorrhage from contrast agent extravasation after mechanical revascularization in ischemic stroke.
- Trial name
- NCT06032819
- Volunteers
- 500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ischemic Stroke
Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Registry 2
The aim of this study is to clarify treatment status and clinical results of acute cerebral ischemia after approval of clot retriever in Japan, and also to obtain a basis for comparative studies.
- Trial name
- NCT02419794
- Testing
- endovascular treatment
- Where
- Japan
- Volunteers
- 2,420 people
- Sponsor
- Hyogo Medical University
Stroke, Thromboses, Intracranial
Stroke Thrombectomy and Aneurysm Registry
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the…
- Conditions
- Stroke, Thromboses, Intracranial, Aneurysm, Brain
- Trial name
- STAR (NCT04994756)
- Testing
- Stroke/Thrombectomy/Aneurysm-specific surgical procedures
- Where
- 63 sites in United States, Canada and 7 more
- Volunteers
- 40,000 people
- Sponsor
- Medical University of South Carolina
Stroke (Subacute)
Effect of DFM on Quadriceps Spasticity in Stroke Patients
The goal of this clinical trial is to learn if deep friction massage works to reduce quadriceps muscle spasticity in adults with sub-acute Stroke.
- Trial name
- NCT07537322
- Testing
- Deep Friction Massage, Physical Therapy Exercise only
- Volunteers
- 30 people
- Sponsor
- Majmaah University
Stroke
Group Lifestyle Balance™ for Individuals With Stroke (GLB-CVA)
The purpose of this RCT is to examine the efficacy of the Group Lifestyle Balance (GLB) program adapted for people with stroke (CVA) on primary (weight) and secondary outcomes at 3, 6, 12 months from enrollment into the program.
- Trial name
- GLB-CVA (NCT03873467)
- Testing
- Group Lifestyle Balance, Usual Care
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor Research Institute
Stroke
Evaluation of Whether Functional Strength Training Can Enhance Recovery of Mobility After Stroke
The purpose of this study is to test the hypothesis that adding functional strength training to UK conventional therapy improves muscle function and walking than either UK conventional therapy alone or increased intensity of UK…
- Trial name
- NCT00322192
- Testing
- Conventional UK Physical therapy, Increased intensity of UK conventional physical therapy, UK conventional physical therapy plus functional strength training
- Where
- 4 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- St George's, University of London
Stroke, Sleep Apnea
Impact of Early Ventilation in Stroke Outcomes in Patients With Sleep Apnea After First Ever Stroke
To evaluate the impact of early ventilation in stroke outcomes in patients with sleep apnea and first ever stroke, 1 month after stroke.
- Trial name
- NCT04903951
- Testing
- Adaptive Servoventilation (ASV) therapy, Best medical treatment
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Philips Portuguesa S.A.
Alzheimer Disease, Dementia
Innovations in Dementia Empowerment and Action
The lack of efficacious research-based interventions for such vulnerable older adults with Alzheimer's disease and related dementias (AD/RD) and their caregivers (CGs) is a significant public health problem.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Parkinson Disease Dementia
- Trial name
- IDEA (NCT03550131)
- Testing
- Innovations in Dementia Empowerment and Action (IDEA), Reducing Disabilities in Alzheimer's Disease (RDAD)
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University of Washington
Stroke, Ischemic Stroke
Hyperbaric Oxygen Post Established Stroke
The purpose of this study is to examine the role of Hyperbaric Oxygen Therapy (HBOT) in improving neurological function in patients who are 6 to 36 months post ischemic stroke.
- Conditions
- Stroke, Ischemic Stroke, Established Stroke
- Trial name
- HOPES (NCT02582502)
- Testing
- Hyperbaric Oxygen
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of British Columbia
Stroke
Evaluating Error Augmentation for Neurorehabilitation
This is a sub-project of a larger NIDRR Grant. One promising form of robotic training that leverages the power of neuro-plasticity is error augmentation.
- Trial name
- VREA (NCT01574495)
- Testing
- Error Augmentation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.