Clinical trials: Cerebrovascular Diseases
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Stroke
Multi-segmental Robotic and Technological Upper Limb Rehabilitation in Stroke
Stroke is frequently associated with significant disability and impaired quality of life. Persistent motor impairment is common with often incomplete recovery of motor function in response to rehabilitation, mainly in the upper…
- Trial name
- NCT02879279
- Testing
- Amadeo, Pablo, Diego and Motore., Conventional rehabilitation
- Where
- Italy
- Volunteers
- 247 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Acute Ischemic Stroke
Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)
Though intravenous thrombolysis has been shown to improve symptoms in acute ischemic stroke patients, the recanalization rate remains low (22.6%) and only around 30% of patients benefit from the treatment.
- Trial name
- NCT06677970
- Testing
- BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Yonsei University
Subarachnoid Hemorrhage (SAH), Left Ventricular Dysfunction
Detection of Myocardial Dysfunction in Non-severe Subarachnoid Hemorrhage (WFNS 1-2) Using Speckle-tracking Echocardiography (STRAIN)
Subarachnoid hemorrhage (SAH) can cause transient myocardial dysfunction. Recently, it have been reported that myocardial dysfunctions that occur in SAH are associated with poor outcomes.
- Conditions
- Subarachnoid Hemorrhage (SAH), Left Ventricular Dysfunction, Stress Cardiomyopathy
- Trial name
- SAH-STRAIN (NCT03761654)
- Testing
- Global Longitudinal Strain measure
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Bordeaux
Cryptogenic Stroke, Atrial Fibrillation
Early Detection of Atrial Fibrillation Using Mobile Technology in Cryptogenic Stroke Patients
The purpose of this study is to demonstrate the added value of mobile health (mHealth) to detect atrial fibrillation (AF) early in the care path of cryptogenic stroke and transient ischemic attack (TIA) patients.
- Trial name
- REMOTE (NCT05006105)
- Testing
- seven-day ECG Holter, 24-hour blood pressure monitor, Questionnaire: vision of mHealth
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- Ziekenhuis Oost-Limburg
Stroke
Which Balance Test is More Effective When Evaluating Stroke Patients With a Tele-assessment?
The aim of this study is to compare the feasibility levels and advantages of balance tests applied with tele-assessment methods to clinical application methods in stroke patients and to reveal their effectiveness.
- Trial name
- NCT04793594
- Testing
- Berg Balance Test, Tinetti Balance And Gait Test, Time Up And Go Test
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Stroke, Ambulation Difficulty
New Technology for Individualised, Intensive Training of Gait After Stroke Study I
The overall purpose of this project is to establish the added value of training with the Hybrid Assistive Limb (HAL) exoskeleton system as part of regular rehabilitation intervention programs after stroke.
- Conditions
- Stroke, Ambulation Difficulty, Hemiparesis
- Trial name
- HAL-RCT-II (NCT02545205)
- Testing
- Hybrid Assistive Limb (HAL), Conventional gait training
- Where
- 2 sites in Sweden
- Volunteers
- 2 people
- Sponsor
- Danderyd Hospital
Stroke
Effects of High-intensity Aerobic Training on Balance, Walking Capacity, and Quality of Life in Patients With Sub-acute Stroke.
Stroke is one of the major cause of morbidity and mortality and the leading cause of disability in adults all around the world. Stroke survivors can suffer several neurological impairments and deficits which have an important…
- Trial name
- NCT04752124
- Testing
- Exercise Therapy, conventional therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Government College University Faisalabad
Ischemic Stroke
Effects of Intravascular Laser Irradiation of Blood for Mitochondral Dysfunction in Cerebral Ischemic Stroke
Background : This research is designed through randomization, control, and double-blind trial to explore the clinical effectiveness of intravenous laser irradiation of blood for ischemic stroke patient; The research will further…
- Trial name
- NCT06932627
- Testing
- ILIB
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Intracranial Aneurysm
Prospective Study on Embolization of Intracranial Aneurysms With Pipeline™ Embolization Device
The purpose of this study is to assess the safety and effectiveness of the Pipeline™ device in the treatment of unruptured, wide-neck intracranial aneurysms.
- Trial name
- PREMIER (NCT02186561)
- Testing
- Pipeline™ Embolization Device/ Pipeline™Flex Embolization Device
- Where
- 23 sites in United States, Canada
- Volunteers
- 197 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Stroke, Hemiparesis
Recovery of Motor Skills With the Use of Artificial Intelligence and Computer Vision
To investigate the impact of algorithms utilizing artificial intelligence technology and computer vision on the recovery of motor functions within the context of rehabilitation practice for patients who have experienced a…
- Conditions
- Stroke, Hemiparesis, Spasticity as Sequela of Stroke, Dysmetria
- Trial name
- NCT06183970
- Testing
- AssistI patients, Habilect patients
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health
Stroke, Tele-rehabilitation
Telerehab Exerbrain: Bridging Physical and Cognitive Therapy in Stroke
The goal of this clinical trial is to learn if a web-based exercise and cognitive training (physical-cognitive) program works to improve movements and brain function in adults with long-term stroke.
- Conditions
- Stroke, Tele-rehabilitation, Exercise, Motor Abilities
- Trial name
- NCT07446062
- Testing
- Web-Based Physical-Cognitive Telerehabilitation Exergaming
- Volunteers
- 52 people
- Sponsor
- Chiang Mai University
Pseudoaneurysm, Carotid, Pseudoaneurysm
Treatment (Compassionate) Use of Device - PK Papyrus
The purpose of this study is to evaluate the clinical use of the PK Papyrus Coronary Stent Graft System, a Humanitarian Use Device (HUD) approved by the FDA under a Humanitarian Device Exemption.
- Trial name
- NCT05436470
- Testing
- PK Papyrus
- Where
- United States
- Sponsor
- University of Miami
Cerebrovascular Accident
Acetylcholinesterase Inhibitors to Improve Cognitive Function and Overall Rehabilitation After a Stroke
This study will evaluate the effectiveness of treatment with acetylcholinesterase inhibitors in improving cognitive function and overall rehabilitation in elderly stroke survivors.
- Trial name
- NCT00227994
- Testing
- Galantamine, Donepezil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Thrombosis, Atherothrombosis
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer
To date, the investigators have successfully employed a radiotracer (18F-sodium fluoride) as a marker of necrotic inflammation in human atherosclerosis.
- Conditions
- Thrombosis, Atherothrombosis, Myocardial Infarction, STEMI
- Trial name
- iThrombus (NCT03943966)
- Testing
- 18F-GP1 PET CT
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Edinburgh
Traumatic Brain Injury, Intracranial Hemorrhages
Andexanet Alfa for Reversal of Factor Xa Inhibitors in Traumatic Brain Injury: A Retrospective Single-Centre Study
Elderly patients on direct oral anticoagulants (DOACs), specifically factor Xa (FXa) inhibitors such as apixaban and rivaroxaban are at elevated risk of haematoma expansion following traumatic brain injury (TBI).
- Trial name
- AA-TBI (NCT07898982)
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation, Anticoagulants and Bleeding Disorders
Left Atrial Appendage Occlusion for AF Patients Unable to Use Oral Anticoagulation Therapy
Up to 5% of Atrial Fibrillation (AF) patients may have or develop contraindications to use oral anticoagulation (OAC). Randomized controlled trial (RCT) data suggest that Left Atrial Appendage Occlusion (LAAO) may provide a…
- Trial name
- COMPARE-LAAO (NCT04676880)
- Testing
- Left atrial appendage occlusion (Watchman FLX or Amplatzer Amulet)
- Where
- 14 sites in Netherlands
- Volunteers
- 609 people
- Sponsor
- R&D Cardiologie
Myocardial Infarction, Cerebral Infarction
Acute Myocardial Infarction and Acute Cerebral Infarction (AMIAC) Registry and Follow-up
A registry of consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction were conducted at the Guangdong General Hospital or the First Affiliated Hospital of Guangzhou…
- Conditions
- Myocardial Infarction, Cerebral Infarction, Chronic Kidney Diseases, Mortality
- Trial name
- AMIAC (NCT03166696)
- Where
- 3 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Subdural Hematoma
Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study
The goal of this clinical trial is to test in moderately symptomatic chronic subdural hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an alternative to conventional open surgery.
- Trial name
- CHESS (NCT06347796)
- Testing
- Conventional Surgery, Middle Meningeal Artery Embolization (MMAE)
- Where
- 31 sites in United States
- Volunteers
- 520 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Stroke
Non-Heme Iron Load Quantification in the Brain - MRI of Patients With Stroke
This study will determine if MRI imaging can be used to estimate the amount of iron in areas of the brain affected by a stroke. This may help future patients if the scan can be used to predict the amount of brain damage and…
- Trial name
- NCT01829386
- Testing
- MRI scans with non heme iron levels
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
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