Clinical trials: Cervical Cancer Radiation Complications
Cervical Cancer
Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Stage I Cancer of the Cervix
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00054067
- Testing
- cisplatin, adjuvant therapy, conventional surgery
- Where
- 50 sites in United States, Japan
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer
Post Market Clinical Follow-up Study Venezia
The investigational device is the Advanced Gynecological Applicator (AGA) Venezia configuration, an applicator to treat locally advanced stage cervical cancer.
- Trial name
- NCT03958357
- Testing
- Advanced Gynecological Applicator configuration
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 41 people
- Sponsor
- Nucletron Operations BV
Cervical Cancer
Concurrent Chemoradiotherapy for Cervical Cancer in Elderly Women
The purpose of this study is to evaluate the efficiency and safety of weekly Cisplatin /Liposome paclitaxel concurrent chemoradiothrapy in the treatment of locally advanced cervical cancer in elderly women.
- Trial name
- NCT01594099
- Testing
- irradiation, Cisplatin, liposome paclitaxel
- Volunteers
- 45 people
- Sponsor
- Xi'an Jiaotong University
Nasopharyngeal Neoplasms, Mortality
Hyperfractionated Intensity-modulated Radiotherapy (IMRT) Versus Conventional Fraction IMRT for Patients With Loco-regionally Recurrent Nasopharyngeal Carcinoma.
This study evaluates the hyperfractionated IMRT in the treatment of patients with locally recurrent nasopharyngeal carcinoma. Half of participants will receive hyperfractionated IMRT, while the other half will receive…
- Conditions
- Nasopharyngeal Neoplasms, Mortality, Quality of Life, Complications
- Trial name
- NCT02456506
- Testing
- Hyperfractionated IMRT, Conventional Fraction IMRT
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Sun Yat-sen University
Head-and-neck Cancer
Long Term Complications in Head and Neck Cancer Patients
Problem: With increasing numbers of cancer survivors, strategies to prevent long-term complications in cancer patients become more important.
- Trial name
- NCT04257968
- Testing
- Ultrasonography, MRI, Neuro Psychological Assessment Battery
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Oral Cancer, Radiotherapy; Complications
Effect of FDG-PET/CT for Simulation and Radiation Treatment Planning in Oral Cancer Patients
This study evaluates the effect of FDG-PET/CT for Simulation and Radiation Treatment Planning in oral Cancer patients. Progress-free survival (PFS) will be compared with historical control as defined in the protocol
- Trial name
- NCT03008694
- Testing
- PET/CT
- Volunteers
- 100 people
- Sponsor
- Zhongnan Hospital
Cervical Cancer
Adjuvant Concurrent Chemoradiotherapy Versus Radiotherapy in Early-stage Cervical Cancer Patients
To evaluate if adjuvant concurrent chemoradiotherapy is associated with a recurrence-free survival benefit in comparison with radiotherapy alone in selected intermediate risk cervical cancer after radical surgery.
- Trial name
- NCT05277688
- Testing
- adjuvant concurrent chemoradiotherapy, radiotherapy
- Where
- 2 sites in China
- Volunteers
- 340 people
- Sponsor
- Ruijin Hospital
Cancer of the Cervix
Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients
The researchers plan: To undertake clinical studies of radiotherapy with or without the administration of the chemotherapeutic agent cisplatin, known to be a radiosensitizer; To perform pre-clinical studies of the…
- Trial name
- NCT00122746
- Testing
- Radiotherapy alone, Radiotherapy with cisplatin
- Where
- 5 sites in India, South Africa and 3 more
- Volunteers
- 322 people
- Sponsor
- International Atomic Energy Agency
Metastatic Non Small Cell Lung Cancer, Metastatic Bladder Cancer
Study Evaluating the Safety and the Efficacy of Combination of Atezolizumab, Tiragolumab and and Stereotactic Body Radiation Therapy in Patients With Oligometastatic Multiorgan (IMMUNOs-SBRT)
This study (phase I clinical trial and expansion cohorts) will evaluate safety and efficacy of combination of atezolizumab and tiragolumab, with concomitant or sequential SBRT for four oligometastatic cancer cohorts.
- Conditions
- Metastatic Non Small Cell Lung Cancer, Metastatic Bladder Cancer, Metastatic Renal Cell Carcinoma, Metastatic Head and Neck Cancer
- Trial name
- IMMUNOs-SBRT (NCT05259319)
- Testing
- Atezolizumab 60 MG/1 ML Intravenous Solution [TECENTRIQ], Tiragolumab, Stereotactic body radiation therapy (SBRT)
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Georges Francois Leclerc
Cervical Cancer, Radiotherapy
Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer
This is a prospective, single-center, phase II, randomized, window-of-opportunity trial initiated by researchers. The research hypothesis is that metformin can improve the level of hypoxia in locally advanced cervical cancer and…
- Conditions
- Cervical Cancer, Radiotherapy, Metformin, Hypoxia
- Trial name
- NCT06353061
- Testing
- Metformin, Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer, Acquired Immunodeficiency Syndrome
Cisplatin and Radiation Therapy in Treating Patients With HIV-Associated Locally Advanced Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01590017
- Testing
- cisplatin, external beam radiation therapy
- Where
- 2 sites in South Africa, Zimbabwe
- Volunteers
- 41 people
- Sponsor
- AIDS Malignancy Consortium
Nasopharyngeal Carcinoma, Radiotherapy; Complications
De-escalated Radiotherapy for Primary Tumor After Neoadjuvant Therapy With Toripalimab Plus Chemotherapy for Nasopharyngeal Carcinoma
In the IMRT era, patients with stage II-III (AJCC8th) nasopharyngeal carcinoma achieve high local control. However, survivors are increasingly experiencing late radiation-induced toxicities.
- Conditions
- Nasopharyngeal Carcinoma, Radiotherapy; Complications, IMMUNOTHERAPY
- Trial name
- NCT06313450
- Testing
- de-escalated radiotherapy, conventional radiotherapy
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Sun Yat-sen University
Cervix Cancer
Megavoltage CT (MVCT) Imaging for Intracavitary Radiation Treatment in Cervix Cancer
The Cross Cancer Institute has recently acquired a tomotherapy radiotherapy treatment machine; the first of its kind in Canada. It has the potential to improve cancer treatment outcomes where radiotherapy is used.
- Trial name
- NCT00124423
- Testing
- Megavoltage CT scan
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- AHS Cancer Control Alberta
Cervical Cancer
Concomitant Curcumin Palliative Radiotherapy in Advanced Cervical Cancer Trial
The goal of this clinical trial is to test curcumin as an adjunct treatment in patients with cervical cancer receiving standard-of-care palliative radiation. The main questions it aims to answer are: 1.
- Trial name
- CuPRAC (NCT05947513)
- Testing
- Curcumin, Palliative radiotherapy
- Where
- Ethiopia
- Volunteers
- 27 people
- Sponsor
- Addis Ababa University
Cervical Cancer
Modulated Electro-Hyperthermia Plus Chemo-radiation for Locally Advanced Cervical Cancer Patients in South Africa
This is a phase III randomised clinical trial. The aim is to investigate the clinical effects of the addition of modulated electro-hyperthermia (mEHT) to standard treatment protocols (chemoradiotherapy, CRT) for Human…
- Trial name
- mEHT (NCT03332069)
- Testing
- Modulated electro-hyperthermia, External beam radiation, Cisplatin
- Where
- South Africa
- Volunteers
- 236 people
- Sponsor
- Jeffrey Kotzen
Caries,Dental, Head and Neck Cancer
Prevention of Caries in Head and Neck Cancer Survivors Who Underwent Radiotherapy
One of the long-term side effects of head and neck radiotherapy (RT) is radiation-induced tooth decay. Hyposalivation, associated with radiation therapy, further increases caries susceptibility and caries progression, due to the…
- Conditions
- Caries,Dental, Head and Neck Cancer, Radiotherapy; Complications
- Trial name
- RADIOCARIES (NCT06308796)
- Testing
- Application of CaP dental mousse
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Urinary Bladder Cancer, Melanoma
MAGE-A4ᶜ¹º³²T for Multi-Tumor
This study will investigate the safety and tolerability of MAGE-A4ᶜ¹º³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker and whose urinary bladder, melanoma, head and neck, ovarian, non-small cell lung…
- Conditions
- Urinary Bladder Cancer, Melanoma, Head and Neck Cancer, Ovarian Cancer
- Trial name
- NCT03132922
- Testing
- Autologous genetically modified MAGE-A4ᶜ¹º³²T cells, Autologous genetically modified MAGE-A4c1032T cells combined with low dose radiation
- Where
- 11 sites in United States, Canada
- Volunteers
- 71 people
- Sponsor
- USWM CT, LLC
Cervical Cancer
DNA Array Analysis of Patients With Cervical Cancer
The goal of this clinical research study is to find out if the expression of certain genes is linked with the response of cervical cancer to radiation.
- Trial name
- NCT00512551
- Testing
- Tumor Biopsies
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Radiotherapy; Complications, Head and Neck Cancer
Individualization of Nutritive Sensory Support Of Radiation Therapy
Nutritional deficiency and subsequent weight loss in patients with head and neck cancer is a common problem and a negative predictor of treatment outcomes and mortality, as well as quality of life.
- Trial name
- NCT05046028
- Testing
- Oral nutritional supplements (ONS) with a cooling effect + ONS without a sensor component and taste + standard diet, ONS without a sensor component and taste + standard diet, Standard diet
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Radiological Centre of the Ministry of Health of Russia
Head and Neck Neoplasms, Radiotherapy; Complications
The Impact of Dental Health on Complications During and Following Radiotherapy in the Head and Neck Region.
Study the risk of complications after dental extractions in patients recieving radiotherapy.
- Conditions
- Head and Neck Neoplasms, Radiotherapy; Complications, Extracting Own Teeth
- Trial name
- NCT06840639
- Testing
- Dentoalveolar surgery
- Where
- Sweden
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital