Clinical trials: Cervical Cancer Radiation Complications
Cervical Cancer
Palliative Radiation for Advanced Cervical Cancer
The present study is proposed to compare a rapid fractionation schedule of 1 week compared to a protracted schedule of 6-8 weeks for palliation for locally advanced cervical cancer.
- Trial name
- RAPPAL (NCT03997110)
- Testing
- Short course palliative radiation., Long course palliative treatment.
- Where
- India
- Volunteers
- 230 people
- Sponsor
- Tata Memorial Hospital
Locally Advanced Cervical Carcinoma
Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy
To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with…
- Trial name
- EROS3 (NCT06398938)
- Testing
- Interventional Radiotherapy
- Where
- Italy
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer
Comparative Study of Different Neoadjuvant Therapies Before Radical Hysterectomy in Stage Ib2-IIa2 Cervical Cancer
For stage Ib2-IIa2 cervical cancer patients, neoadjuvant therapy followed by radical hysterectomy and pelvic lymphadenectomy is one of the managements.
- Trial name
- NCT03243825
- Testing
- combination group, chemotherapy group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese Academy of Medical Sciences
Gynecological Tumor, Adaptive Radiotherapy
Adaptive Radiotherapy in Patients With Gynecological Tumors
Prospective randomized evaluation of adaptive radiotherapy in the definitive radiotherapy of locally advanced gynecologic carcinoma (e.g.
- Conditions
- Gynecological Tumor, Adaptive Radiotherapy, Radiation, Curative Treatment
- Trial name
- ProART (NCT06230549)
- Testing
- Adaptive Radiotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Essen
Cervical Cancer
Cisplatin Combined With Radiation Therapy and Hyperthermia in Treating Patients With Stage II, Stage III, or Stage IV Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00008112
- Testing
- cisplatin, hyperthermia treatment, brachytherapy
- Where
- 4 sites in Netherlands
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recurrent Cervical Carcinoma, Metastatic Cervical Carcinoma
Tislelizumab and Radiotherapy for Recurrent Cervical Cancer
This study is a prospective, multicenter, phase II clinical trial to evaluate the efficacy and safety of albumin-bound paclitaxel plus bevacizumab for platinum-resistant recurrent epithelial ovarian cancer.
- Conditions
- Recurrent Cervical Carcinoma, Metastatic Cervical Carcinoma, Persistent Cervical Carcinoma, Radiotherapy
- Trial name
- NCT05310383
- Testing
- Tislelizumab plus radiotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Lei Li
Cervical Cancer, Radiation Toxicity
Radiation Therapy and Cisplatin With or Without Amifostine for Patients With Stage IIIB or IVA Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00012012
- Testing
- Amifostine trihydrate, Cisplatin, Intracavitary brachytherapy
- Where
- 17 sites in United States
- Volunteers
- 45 people
- Sponsor
- Radiation Therapy Oncology Group
Squamous Carcinoma, Head and Neck Cancer
Multimodal Monitoring of Radiotherapy Response in Squamous Cell Cancer
The study's aim is to define imaging and molecular bio-markers for prediction of radiotherapy response of squamous cell carcinomas, in an early treatment phase.
- Conditions
- Squamous Carcinoma, Head and Neck Cancer, Anal Cancer, Lung Cancer
- Trial name
- MORRIS (NCT02379039)
- Where
- Sweden
- Volunteers
- 118 people
- Sponsor
- Umeå University
Cervical Cancer
Comparing Study Between Concurrent Chemoradiation and New Combination Treatment in Cervical Cancer Patients
The purpose of this study is: to compare the effectiveness between the new strategy of treatment (given cis-platinum plus gemcitabine-neoadjuvant chemotherapy followed by surgery),and standard treatment (given…
- Trial name
- TGOCphaseIII (NCT01000415)
- Testing
- Neoadjuvant chemotherapy followed by surgery
- Where
- Thailand
- Volunteers
- 824 people
- Sponsor
- Thai Gynecologic Oncology Collaborative Group
Cervical Cancer, Stage IIB
Use of a Fermented Dairy Beverage in Cervical Cancer Patients Undergoing Concurrent Chemoradiation Therapy
Many cancer survivors have increased risk of intestinal damage, affecting the quality of life of patients. The role of intestinal microbiota on the development of gastrointestinal toxicity and radiation enteritis has been…
- Trial name
- NCT05736315
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- National Institute of Cancerología
Female
Dostarlimab, Cisplatin and Etoposide in Combination With Radiotherapy in Sandwich Sequence for Small Cell Neuroendocrine Cervical Carcinoma
Add-on dostarlimab to chemoradiation with etoposide and cisplatin and radiotherapy can improve progression-free survival (PFS) compared with historical controls who were treated with chemoradiation alone in SCNECC
- Trial name
- NCT07336147
- Testing
- Dostarlimab
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Head and Neck Cancer, Mucositis
Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
RATIONALE: Doxepin hydrochloride may be an effective treatment for oral mucositis pain in patients undergoing radiation therapy with or without chemotherapy.
- Conditions
- Head and Neck Cancer, Mucositis, Oral Complications of Radiation Therapy, Pain
- Trial name
- NCT01156142
- Testing
- doxepin hydrochloride
- Where
- 120 sites in United States
- Volunteers
- 155 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cervical Cancer
Phase II Clinical Trial of Concurrent Chemoradiotherapy Combined Nimotuzumab for Stage IIB-IVA Cervical Cancer
The purpose of this phase II trial is to determine the feasibility and efficacy of nimotuzumab injection combined with concurrent chemoradiotherapy for initially inoperable locally advanced cervical cancer.
- Trial name
- NCT02705612
- Testing
- Cisplatin, External Beam Radiation Therapy, Internal Radiation Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Cervical Cancer
VMAT Concurrent Cisplatin Plus Nab-paclitaxel for Local Advanced Cervical Cancer
This is a single arm, open-lable Phase I clinical trial. Eligible patients will have Histologically proven stage IB2-IVA cervical cancer.
- Trial name
- NCT04017377
- Testing
- Drug: Cisplatin; nab-paclitaxel
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Peking University Third Hospital
Cervical Cancer
Safety Study of Nelfinavir + Cisplatin + Pelvic Radiation Therapy to Treat Cervical Cancer
Nelfinavir will increase the efficacy of Cisplatin based chemo- radiation therapy for locally advanced cervical cancer.
- Trial name
- NCT01485731
- Testing
- Nelfinavir, Cisplatin, Pelvic External Beam Radiation Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Miami
Malignant Tumor of Head and/or Neck, Radiotherapy; Complications
Systematic Oral Education for Prevention of Oral-related Complications Caused by Radiotherapy for Head and Neck Cancer
A study on the efficacy of systematic oral health education for the prevention of oral-related complications caused by radiotherapy for head and neck malignant tumors
- Trial name
- NCT06690346
- Testing
- Systematic oral health education, Routine oral health education
- Where
- China
- Volunteers
- 150 people
- Sponsor
- West China Hospital
Uterine Cervical Neoplasms
Exclusion of Non-involved Uterus From the Target Volume in Locally Advanced Cervical Cancer
Both toxicity and local relapse are major concerns in the treatment of locally advanced cervical cancer. The purpose of this study is to ameliorate both by integrating modern imaging (diffusion weighted magnetic resonance…
- Trial name
- EXIT (NCT03542942)
- Testing
- treatment with EXIT-target volume
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Ghent
Uterine Cervical Neoplasms
A Phase II Clinical Trial of Chemo-radiotherapy in Combination With INO-3112 in Patients With Locally Advanced Cervical Cancer
The aim of this study is to assess the potential benefit of the addition of immunotherapy with VGX-3100 and INO-9012 (i.e. INO-3112) to concomitant CRT or, to concomitant CRT and continued as adjuvant in patients with locally…
- Trial name
- NCT02501278
- Testing
- INO-3112 vaccine, Radiotherapy (Extrernal beam radiotherapy + brachytherapy), Cisplatin chemotherapy
- Where
- Switzerland
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Pembrolizumab Concurrent With and Following Carbon-ion Radiotherapy for Locally Advanced Cervical Adenocarcinoma
The goal of this clinical trial is to learn if pembrolizumab works for cervical adenocarcinoma treat with concurrent chemo-carbon-ion radiaotherapy (CIRT).
- Trial name
- BROTHER (NCT06805864)
- Testing
- Pembrolizumab (KEYTRUDA®)
- Where
- Japan
- Volunteers
- 45 people
- Sponsor
- Gunma University
Cervical Cancer, Endometrial Cancer
Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study
The primary aim of the trial is to investigate the late effects of hypofractionated external radiation (39 Gy in 13 fractions) in patients requiring post-operative radiation for early-stage cervical and endometrial cancers.
- Trial name
- PARCERII (NCT05857631)
- Testing
- Hypofractionated Image guided External Beam Radiation Therapy (EBRT), Cisplatin, Vaginal brachytherapy
- Where
- 2 sites in India
- Volunteers
- 90 people
- Sponsor
- Tata Memorial Centre