Clinical trials: Cervical Ripening and Induction of Labor
Labour Onset and Length Abnormalities, Labor; Forced or Induced, Affecting Fetus or Newborn
Dilapan-S/Dilasoft E-Registry in Induction of Labor
International Observational E-Registry on the use of DILAPAN-S® osmotic dilator / DILASOFT® osmotic dilator for cervical ripening prior to labour induction.
- Trial name
- DSREGISTRYIL (NCT02318173)
- Testing
- Dilapan-S
- Where
- 11 sites in United States, Czechia and 5 more
- Volunteers
- 444 people
- Sponsor
- Medicem International CR s.r.o.
Cervical Ripening and Induction of Labor
Comparison Between Vaginal Misoprostol Gel and Oral Misoprostol Solution in Induction of Labor
The goal of this clinical trial is to study the efficacy of vaginal versus oral misoprostol solution in cervical ripening for induction of labor.
- Trial name
- NCT06874049
- Testing
- Vaginal misoprostol, Oral misoprostol solution (OMS)
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hagar Muhammad Abdulfattah Muhammad
Labor, Induced
Efficacy and Safety of Hourly Titrated Misoprostol Versus Vaginal Dinoprostone and Misoprostol for Cervical Ripening and Labor Induction
This study evaluates the efficacy and safety of the administration of oral misoprostol versus vaginal dinoprostone and vaginal misoprostol for cervical ripening and labor induction.
- Trial name
- NCT02902653
- Testing
- Oral misoprostol, Vaginal misoprostol, Vaginal dinoprostone
- Where
- Spain
- Volunteers
- 372 people
- Sponsor
- Oihane Lapuente Ocamica
Induced Labor, Cervical Ripening
Safety and Feasibility of the INGA Sensor System for Fetal and Uterine Monitoring During Cervical Ripening
The goal of this clinical trial is to learn about the safety and performance of the INGA Sensor System when used with the INGA balloon catheter during cervical ripening for labor induction in pregnant individuals at term.
- Conditions
- Induced Labor, Cervical Ripening, Cervical Ripening and Induction of Labor, Balloon Catheter for Labor Induction
- Trial name
- INGA-SENPe (NCT07846111)
- Testing
- Cervical ripening, labor Induction, uterus and fetal monitoring
- Where
- Estonia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aalto University
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Labor, Induced, Cervical Ripening
Prehospital Cervical Ripening Before Induction and the Maternal Experience
This is a randomized study evaluating the impact of pre-hospital cervical ripening with a transcervical Foley balloon before labor induction in full-term pregnancies on the length of inpatient labor induction and maternal…
- Trial name
- "PRIME" (NCT01641601)
- Testing
- Outpatient transcervical Foley balloon
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Vaginal Delivery, Cesarean Section
Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction
This is a comparative trial between oxytocin alone and dinoprostone for cervical ripening in unfavorable cervix pregnant women with 38 or more weeks of gestational age.
- Trial name
- SOFTNES (NCT01190163)
- Testing
- Dinoprostone, Oxytocin
- Where
- 4 sites in Brazil
- Volunteers
- 170 people
- Sponsor
- Ferring Pharmaceuticals
Labor, Induced
Topical Anesthesia During Catheter Insertion for Cervical Ripening (TOLERANCE)
The goal of this RCT is to learn if application of topical anesthetic cream to the perineum and posterior wall of vagina prior to balloon catheter insertion as part of labor induction will reduce pain levels experienced by…
- Trial name
- TOLERANCE (NCT07288021)
- Testing
- Topical Analgesia with Lidocaine-Prilocaine cream
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Bnai Zion Medical Center
Pregnancy Related
Labor Induction With Double Balloon Device, Oral Misoprostol and Concomitant Use of Both
The aim of this study is to compare the rate of cesarean delivery between 3 methods of labor induction: double balloon device, oral misoprostol and combination of the two.
- Trial name
- IDOM (NCT03866772)
- Testing
- Misoprostol Oral Tablet, double balloon device for cervical ripening
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Obesity, Pregnancy
Randomized Controlled Trial: Induction of Labour of Obese Women With Dinoprostone or Single Balloon Catheter
The purpose of this study is to compare the efficacy of single balloon foley catheters to dinoprostone for the induction of labour of obese women.
- Conditions
- Obesity, Pregnancy, Labor, Induced
- Trial name
- NCT01962831
- Testing
- Dinoprostone, Single balloon foley catheter
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Diabetes, Gestational
Outpatient Cervical Ripening With Orally Administered Misoprostol in Diabetics
A. Null Hypothesis: In term pregnancies complicated by diabetes, there is no difference in the time interval from start of induction to delivery when outpatient cervical ripening and labor induction is initiated with orally…
- Trial name
- NCT00514618
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Pregnancy, Induction of Labor
Natural Cervical Ripening to Prevent Pharmacological Induction of Labor - a Pilot Study.
As of today, around 25% of all vaginal births happen after induction of labor (IOL). The internal guidelines of the University Hospital Zurich currently recommend pregnant women with a non-insulin dependent gestational diabetes…
- Conditions
- Pregnancy, Induction of Labor, Gestational Diabetes Mellitus (GDM)
- Trial name
- Cervinat (NCT07587632)
- Testing
- Membrane sweaping and Breast massage
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- University of Zurich
Post Term Pregnancy, Premature Rupture of Membrane
Dilapan-S®: A Multicenter US E-registry
Objective of this registry is to collect a representative set of real world data on the use of Dilapan-S® for pre-induction cervical ripening in daily clinical practice.
- Conditions
- Post Term Pregnancy, Premature Rupture of Membrane, Fetal Growth Retardation, Oligohydramnios
- Trial name
- NCT04451109
- Testing
- Dilapan-S
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Medicem Technology s.r.o.
Induction of Labor Affected Fetus / Newborn, Cervical Ripening
Patient Satisfaction During Outpatient Versus Inpatient Foley Catheter Induction of Labor
Labor induction is one of the most common obstetric procedures performed in the U.S. In 2012, the last year for which data is available, 23.7% of all deliveries were the result of inductions.
- Conditions
- Induction of Labor Affected Fetus / Newborn, Cervical Ripening, Patient Satisfaction
- Trial name
- NCT02975167
- Testing
- Outpatient Cervical Ripening, Inpatient Cervical Ripening, Foley catheter placement
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Labor, Induced
Recombinant Human Relaxin (rhRlx) in Pregnant Women Scheduled for Induction of Labor
The purpose of this study is to assess the safety and efficacy of rhRlx for cervical ripening, when compared to a placebo.
- Trial name
- NCT00259103
- Testing
- Serelaxin
- Where
- 3 sites in Russia
- Volunteers
- 72 people
- Sponsor
- Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies
Cervical Ripening
Comparison Between Vaginal and Sublingual Misoprostol 50 µg for Cervical Ripening Prior to Induction of Labor
To analyze whether there is a statistically significant difference in the modifications present in the uterine cervix 6 hours after administration of misoprostol 50 µg through vaginal versus sublingual routes.
- Trial name
- CMVS (NCT02732522)
- Testing
- Sublingual misoprostol, Vaginal misoprostol
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidad de la Republica
Nulliparous Women Who Scheduled for Labor Induction, Pregnancy
Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
The purpose of this study is to compare the effectiveness of sequential versus combined multimodal cervical ripening strategies to achieve vaginal delivery within 24 hours among nulliparous patients with singleton, vertex…
- Trial name
- RAPID-DS (NCT07717502)
- Testing
- Sequential Cervical Ripening, Inpatient Combined Cervical Ripening
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Ochsner Health System
Cervical Ripening, Induction of Labor
Study of the Effectiveness of Cervical Ripening Balloon With and Without Oxytocin
Study Purpose: The purpose of this study is to determine the optimal method for induction of labor in multiparous women who present with an unfavorable cervix.
- Conditions
- Cervical Ripening, Induction of Labor, Multiparity
- Trial name
- NCT03138252
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Induction of Labor
Comparing Outpatient and Inpatient Use of a Cervical Balloon for Starting Labor in Low-Risk Pregnancies.
Why was this study done? About 20-30% of pregnancies involve labor being started artificially, known as induction. One way to do this is with a balloon catheter placed in the cervix, which helps prepare the body for labor.
- Trial name
- Cook (NCT06983535)
- Testing
- cervical balloon catheter
- Where
- 4 sites in Belgium
- Volunteers
- 358 people
- Sponsor
- Ziekenhuis Oost-Limburg
Induction of Labor
DOuble-BAlloon Versus PROstaglandin E2 for Cervical Ripening in Low Risk Pregnancies
To compare the effectiveness and safety of double balloon catheter and vaginal insert Prostaglandin E2 in cervical ripening prior to Induction of Labor in low-risk women from 39+0 to 40+6 weeks of gestation.
- Trial name
- DOBA-PRO (NCT04747301)
- Testing
- Double-balloon catheter (UTAH CVX-RIPE) for cervical ripening, Dinoprostone 10mg (Propess)
- Where
- Vietnam
- Volunteers
- 540 people
- Sponsor
- Hanoi Obstetrics and Gynecology Hospital