Clinical trials: Cesarean Scar Defect
Uterine Scar Defect
Suture of UTerus and Ultrasound Repair Evaluation
This study compares three techniques of uterine closure on myometrium thickness evaluated by ultrasound six months after the primary cesarean.
- Trial name
- SUTURE (NCT01860859)
- Testing
- Closure of the hysterotomy at the time of primary cesarean
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Defect
Comparison of the Therapeutic Effects of VR and VR + Metformin in the Treatment of Cesarean Section Scar Defect
Cesarean section scar defect (CSD) is a novel recognized cause of postmenstrual abnormal uterine bleeding in women. No clinical guidelines have been issued for the management of CSD.
- Trial name
- NCT05205317
- Testing
- Metformin Hydrochloride Sustained-release Tablets, Vaginal repair
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cesarean Scar Defect
Prevalence, Risk Factors and Consequences Related to Cesarean Scar Defect (Defect in Cesarean Scar)
The rates of cesarean section (CS) are rising all over the world. Worldwide the number of CS is millions every year. CS is one of the most frequently performed operation for women.
- Trial name
- DICE (NCT02717312)
- Where
- Finland
- Volunteers
- 400 people
- Sponsor
- Tampere University Hospital
Scar Niche
Two Dimensional Versus Three Dimensional Transvaginal U/S With or Without SIS
Primary aim: To assess the diagnostic agreement between 2D vs 3D TV U/S with or without SIS for the evaluation of cesarean scar defects and its correlation with symptoms.
- Trial name
- NCT07704788
- Volunteers
- 100 people
- Sponsor
- Sohag University
Scar Niche, Abnormal Uterine Bleeding
Sublingual Misoprostol Versus No Cervical Priming Before Hysteroscopic Resection of Symptomatic Uterine Niches
The purpose of the study is to evaluated whether preoperative sublingual misoprostol can enhance the effectiveness and safety of niche resection in patients with symptomatic uterine niche.
- Conditions
- Scar Niche, Abnormal Uterine Bleeding, Cesarean Section Complications
- Trial name
- NCT07271056
- Testing
- Misoprostol 200mcg Tab, Hysteroscopic resection of uterine niche, Saline-infusion Sonohysterography
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Benha University
Cesarean Section; Dehiscence
The Impact of Cesarean Scar Defects on the Success of Assisted Human Reproduction
The prevalence of Caesarean sections continues to increase around the world. In France, the proportion of Caesarean sections has doubled from 11% in 1981 to 20,2% in 2016, bringing with it an increase in the risk of obstetrical…
- Trial name
- NICHE-ART (NCT04869007)
- Testing
- hysterosonography
- Where
- 5 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Angers
CS Scar Defect(Niche) How to Avoid
Incidence of Caesarean Scar Defect in Cases of Cesarean Section With and Without Bladder Flap Dissection
Anatomically Uterine niche is an iatrogenic pouch-like defect at the site of previous caesarean scar due to defective tissue healing.
- Trial name
- NCT06503627
- Testing
- bladder flap dissection
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Ultrasound Evaluation
Ultrasound Evaluation of Uterine Healing After Vaginal Repair of Cesarean Scar Defect (CSD)
Cesarean scar defect is one of the complications after cesarean section (CSD). CSD may be further caused many long term complications, such as abnormal uterine bleeding, infertility, uterine scar pregnancy and uterine rupture.
- Trial name
- CSD (NCT04786626)
- Testing
- Ultrasound evaluation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Caesarean Section, Cesarean Scar Closure
Single- vs Double-Layer Cesarean Scar Repair and Myometrial Thickness
Cesarean delivery (CD) is one of the most commonly performed surgical procedures worldwide, with a rising incidence particularly in high-income countries.
- Conditions
- Caesarean Section, Cesarean Scar Closure, Cesarean Scar Defect (Isthmococele), Myometrial Thickness
- Trial name
- NCT07323355
- Testing
- Double-Layer Cesarean Scar Repair, Single-Layer Cesarean Scar Repair
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Cesarean Scar Defect (Isthmococele), Pelvic Pain
Single-Layer Versus Double-Layer Uterine Closure After Primary Cesarean Section
This study compares two surgical techniques for closing the uterus after cesarean section: single-layer versus double-layer closure.
- Conditions
- Cesarean Scar Defect (Isthmococele), Pelvic Pain, Spotting, Amenorrhea Secondary
- Trial name
- NCT07611331
- Testing
- Double-layer hysterorrhaphy at primary cesarean section, Single-layer hysterorrhaphy at primary cesarean section
- Where
- Tunisia
- Volunteers
- 384 people
- Sponsor
- Hédi Chaker Hospital
Cesarean Scar Defect
Comparative Study Between Hormonal and Hysteroscopic Management of Cesarean Scar Defect
Up to 70% of women who have had a previous caesarean section experience uterine niche, with 30% having symptoms. Prevalence rates vary between 24-70% using transvaginal ultrasonography and 56-84% using gel/saline instillation…
- Trial name
- NCT06529952
- Testing
- hysteroscopic surgery by resection and endocoagulation, hysteroscopic surgery by endocoagulation only, hormonal treatment
- Where
- 2 sites in Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Post Cesarean Scar Defect, Hysteroscopy
Effects of Hysteroscopy and Transvaginal Surgery on Reproductive Prognosis in Patients With Post Cesarean Scar Defect
The study is to compare hysteroscopic repair and transvaginal intervention for correcting uterine defect in patients with post cesarean scar defect (PCSD) and the reproductive prognosis.
- Trial name
- NCT04096677
- Testing
- hysteroscpy
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Niche
Cesarean Scar Defect: a Prospective, Observational Study.
The study is conducted as part of the doctoral thesis of Natalia Mazur-Ejankowska, a medical doctor undergoing specialist training in obstetrics and gynecology at the Department of Obstetrics and Gynecology, Gynecologic Oncology…
- Trial name
- NCT07723157
- Testing
- Transvaginal ultrasonography examination
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Gdansk
Cesarean Section; Dehiscence
Ultrasound Elastography Application in Cesarean Section Scar Defect
Cesarean Section Scar Defect(CSD) is one of the complications after cesarean section. CSD will cause many long term complications, such as abnormal uterine bleeding, infertility, uterine scar pregnancy and uterine rupture.
- Trial name
- NCT05363735
- Testing
- Ultrasound Elastography
- Where
- China
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cesarean Section Complications, Uterine Bleeding
Platelet Rich Plasma for Uterine Scar
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing.
- Conditions
- Cesarean Section Complications, Uterine Bleeding, Pelvic Pain, Menstrual Irregularity
- Trial name
- AA-PRP (NCT05224726)
- Testing
- Platelet Rich Plasma
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cesarean Wound Disruption
The Influence of Endometrial Suturing on the Risk of Uterine Scar Defect
Caesarean section (CS) is the commonest major operation performed on women worldwide with progressively rising incidence. Consequently, long-term adverse sequelae due to uterine scar defect have been increasing.
- Trial name
- NCT03851003
- Testing
- Endometrial suturing, Non- endometrial suturing, Vaginal ultrasonography
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility, Complications; Cesarean Section
Does Cesarean Section Scar Defect (Niche) Affect Implantation Rate?
Cesarean scar defects (CSDs), i.e. deficient uterine scars following a cesarean section, involve discontinuity at the site of a previous Cesarean section scar.
- Trial name
- NCT02371486
- Testing
- hysteroscopic repair of cesarean section defect, Diagnostic Hysteroscopy, Ultrasound Scan
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Cesarean Section Complications, Scar; Deformity
Uterine Closure Techniques and Cesarean Scar Defect Risk
Cesarean operations are one of the most common obsetric operations and have an increasing trend in all over the world. However unfortunately the operation techniques have not been standardized yet.
- Trial name
- NCT05100147
- Testing
- Uterine closure during Cesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Mersin University
Abnormal Uterine Bleeding, Cesarean Section Complications
Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding
The purpose of the study is to compare the clinical efficacy and niche morphological changes following treatment with combined oral contraceptive pills (OCPs) versus a levonorgestrel-releasing intrauterine system (LNG-IUS) in…
- Conditions
- Abnormal Uterine Bleeding, Cesarean Section Complications, Uterine Scar
- Trial name
- NCT07229209
- Testing
- transvaginal ultrasonography, monophasic combined oral contraceptive pill, 52 mg levonorgestrel-releasing intrauterine system
- Where
- Egypt
- Volunteers
- 166 people
- Sponsor
- Benha University
Uterine Scar
Assessment of Single and Double Layer Suturation of Lower Segment Uterine Incision by USG After C/S
After 6 months of cesarean delivery, the investigators will compare uterine incision scar defects of single and double layer suturation of uterine incision by transvaginal ultrasonography.
- Trial name
- NCT03676907
- Testing
- double layer suturation technique
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gazi University