Clinical trials: Cesarean Scar Defect
Cesarean Section; Dehiscence
Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect
GnRH-a will be used to postpone period after vaginal repair for Cesarean Section Scar Defect（CSD） patients with adenomyosis which will be compared with CSD patients with adenomyosis who receive transvaginal surgery without…
- Trial name
- NCT05206682
- Testing
- Leuprorelin
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Caesarean Section, Cesarean Scar Closure
Single- vs Double-Layer Cesarean Scar Repair and Myometrial Thickness
Cesarean delivery (CD) is one of the most commonly performed surgical procedures worldwide, with a rising incidence particularly in high-income countries.
- Conditions
- Caesarean Section, Cesarean Scar Closure, Cesarean Scar Defect (Isthmococele), Myometrial Thickness
- Trial name
- NCT07323355
- Testing
- Double-Layer Cesarean Scar Repair, Single-Layer Cesarean Scar Repair
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Uterine Scar
Assessment of Single and Double Layer Suturation of Lower Segment Uterine Incision by USG After C/S
After 6 months of cesarean delivery, the investigators will compare uterine incision scar defects of single and double layer suturation of uterine incision by transvaginal ultrasonography.
- Trial name
- NCT03676907
- Testing
- double layer suturation technique
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gazi University
Cesarean Wound Disruption
The Influence of Endometrial Suturing on the Risk of Uterine Scar Defect
Caesarean section (CS) is the commonest major operation performed on women worldwide with progressively rising incidence. Consequently, long-term adverse sequelae due to uterine scar defect have been increasing.
- Trial name
- NCT03851003
- Testing
- Endometrial suturing, Non- endometrial suturing, Vaginal ultrasonography
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Uterine Niche
Laparoscopic Versus Transvaginal Approaches in Repair of Uterine Niche: A Randomized Controlled Trial
The treatment of uterine niche ranges from clinical management with expectant or pharmacological treatment, surgical treatment. Approaches for repair include Laparotomy, laparoscopy , hysteroscopy , vaginal.
- Trial name
- isthmocele (NCT04241107)
- Testing
- Laparoscopic repair of Uterine niche, Transvaginal repair of Uterine niche
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cesarean Section Complications
Cesarean Scar Defect (CSD); Prevalence, Risk Factors And Possible Associated Symptoms
The study aims to detect the incidence of Cesarean Scar Defect (CSD) in women undergoing CS in Women Health Hospital (WHH), assiut University, to identify risk factors for development of CSD and identify the possible…
- Trial name
- isthmocele (NCT04605328)
- Testing
- Two dimension and three dimension ultrasound
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cesarean Section; Dehiscence
Ultrasound Elastography Application in Cesarean Section Scar Defect
Cesarean Section Scar Defect(CSD) is one of the complications after cesarean section. CSD will cause many long term complications, such as abnormal uterine bleeding, infertility, uterine scar pregnancy and uterine rupture.
- Trial name
- NCT05363735
- Testing
- Ultrasound Elastography
- Where
- China
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cesarean Section Complications, Uterine Bleeding
Platelet Rich Plasma for Uterine Scar
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing.
- Conditions
- Cesarean Section Complications, Uterine Bleeding, Pelvic Pain, Menstrual Irregularity
- Trial name
- AA-PRP (NCT05224726)
- Testing
- Platelet Rich Plasma
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cesarean Scar Defect (Isthmococele), Pelvic Pain
Single-Layer Versus Double-Layer Uterine Closure After Primary Cesarean Section
This study compares two surgical techniques for closing the uterus after cesarean section: single-layer versus double-layer closure.
- Conditions
- Cesarean Scar Defect (Isthmococele), Pelvic Pain, Spotting, Amenorrhea Secondary
- Trial name
- NCT07611331
- Testing
- Double-layer hysterorrhaphy at primary cesarean section, Single-layer hysterorrhaphy at primary cesarean section
- Where
- Tunisia
- Volunteers
- 384 people
- Sponsor
- Hédi Chaker Hospital
Cesarean Scar Defect
Isthmocele After Two Different Sutures in Cesarean Section
Cesarean delivery (CD) rates are rising globally. about 30% of women delivered by CD in 2015 only in the USA. This increasing CD rate has stimulated an interest in the potential short- and long-term morbidity of CD scars.
- Trial name
- NCT04073264
- Testing
- monofilament
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Cesarean Scar Defect
Impact of a Bladder Flap on Cesarean Scar Niche Development
The goal of this trial is to examine if the completion or omission of a bladder flap impacts the location and formation of cesarean scar niche in women undergoing primary cesarean section.
- Trial name
- B-FIND (NCT07634679)
- Testing
- Bladder flap formation
- Where
- 2 sites in United States
- Volunteers
- 338 people
- Sponsor
- Montefiore Medical Center
Quality of Life, Sexual Activity
Quality of Life and Sexual Function of Vaginal Operation in The Treatment Of Previous Cesarean Scar Defect
The aim of this study is to further demonstrate the safety , validity and quality of (sexual)life of vaginal operation for previous cesarean scar defect resection.
- Trial name
- PCSD (NCT01978067)
- Testing
- transvaginal resection of Uterine Scar
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shu-Qin Chen
Cesarean Scar Defect
Double Vers Single in Cesarean Incision
To assess the effect of single versus double layer closure of caesarean scar on the residual myometrium on the short \& intermediate term.
- Trial name
- NCT05276518
- Testing
- Closure of cesarean section incision
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Abnormal Uterine Bleeding, Cesarean Section Complications
Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding
The purpose of the study is to compare the clinical efficacy and niche morphological changes following treatment with combined oral contraceptive pills (OCPs) versus a levonorgestrel-releasing intrauterine system (LNG-IUS) in…
- Conditions
- Abnormal Uterine Bleeding, Cesarean Section Complications, Uterine Scar
- Trial name
- NCT07229209
- Testing
- transvaginal ultrasonography, monophasic combined oral contraceptive pill, 52 mg levonorgestrel-releasing intrauterine system
- Where
- Egypt
- Volunteers
- 166 people
- Sponsor
- Benha University
Cesarean Scar Defect; Transvaginal Diverticulum Resection
Cesarean Section Defect Mechanism and Transvaginal Repair
Background and aims: Cesarean section defect (CSD) can cause abnormal uterine bleeding or impaired fertility, which severely impaire the quality of life in women of pregnant age.
- Trial name
- NCT05643703
- Testing
- Suture method
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Cesarean Section; Dehiscence
The Impact of Cesarean Scar Defects on the Success of Assisted Human Reproduction
The prevalence of Caesarean sections continues to increase around the world. In France, the proportion of Caesarean sections has doubled from 11% in 1981 to 20,2% in 2016, bringing with it an increase in the risk of obstetrical…
- Trial name
- NICHE-ART (NCT04869007)
- Testing
- hysterosonography
- Where
- 5 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Angers
Ultrasound Evaluation
Ultrasound Evaluation of Uterine Healing After Vaginal Repair of Cesarean Scar Defect (CSD)
Cesarean scar defect is one of the complications after cesarean section (CSD). CSD may be further caused many long term complications, such as abnormal uterine bleeding, infertility, uterine scar pregnancy and uterine rupture.
- Trial name
- CSD (NCT04786626)
- Testing
- Ultrasound evaluation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Caesarean Scar Defect
Sparse Uterine Closure in Cesarean Section
The existence and the characteristics of a wedge- shaped defect in the uterine incision scar were demonstrated by radiologic, ultrasonographic, endoscopic and histologic methods by various authors.
- Trial name
- NCT03930134
- Testing
- sparse uterine suture, one layer uterine closure
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Cesarean Section Complications, Cesarean Wound Disruption
Cesarean Scar Defect Formation After First Cesarean Section.
This study is a prospective observational study which will monitor how cesarean section in the first pregnancy will develop a cesarean scar defect.
- Conditions
- Cesarean Section Complications, Cesarean Wound Disruption, Cesarean Wound; Dehiscence
- Trial name
- NCT03966001
- Testing
- Transvaginal sonography at six months after cesarean section, Transvaginal sonography at twelve months after cesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Uludag University
Cesarean Scar Defect (Isthmococele)
Incision-Parallel Double-Layer Non-Locking Versus Single-Layer Locked Uterine Closure After Primary Caesarean Delivery: A Randomized Controlled Trial
This randomized controlled trial was conducted to compare two uterine closure techniques in women undergoing primary cesarean delivery.
- Trial name
- NCT07841028
- Testing
- Single-Layer Locked Uterine Closure, Double-Layer Incision-Parallel Nonlocking Uterine Closure
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Onur Karaaslan