Clinical trials: Chemoradiotherapy
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery
This randomized phase III trial studies radiation therapy with chemotherapy to see how well they work compared to radiation therapy alone in treating patients with stage I-IIA cervical cancer who previously underwent surgery.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage I Cervical Cancer AJCC v6 and v7
- Trial name
- NCT01101451
- Testing
- Cisplatin, External Beam Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- 719 sites in United States, Japan and 1 more
- Volunteers
- 340 people
- Sponsor
- GOG Foundation
Neoadjuvant Therapy, Concurrent Chemoradiotherapy
Neoadjuvant Immunotherapy Plus Chemotherapy Followed by Concurrent Chemoradiotherapy and Consolidative Immunotherapy for Locally Advanced Non-small Cell Lung Cancer
Consolidative immunotherapy following concurrent chemoradiotherapy, based on the PACIFIC trial, has become the standard treatment for locally advanced non-small cell lung cancer (LANSCLC), leading to a 5-year survival rate of…
- Conditions
- Neoadjuvant Therapy, Concurrent Chemoradiotherapy, Immunotherapy, Locally Advanced Non-Small Cell Lung Cancer
- Trial name
- NCT06734702
- Testing
- Neoadjuvant therapy, Hypo-RT and concurrent chemotherapy, CFRT and concurrent chemotherapy
- Where
- China
- Volunteers
- 497 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer
Combination Chemotherapy Followed By Chemoradiotherapy, With or Without Surgery, in Treating Patients With Resectable Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction
RATIONALE: Drugs used in chemotherapy such as paclitaxel, fluorouracil, and cisplatin use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00069953
- Testing
- filgrastim, pegfilgrastim, cisplatin
- Where
- 97 sites in United States
- Volunteers
- 43 people
- Sponsor
- Radiation Therapy Oncology Group
Locally Advanced Head and Neck Squamous Cell Carcinoma
Sintilimab Plus Hypofractionated Radiotherapy Followed by Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma
Most patients with head and neck squamous cell carcinoma (HNSCC) are diagnosed with locally advanced disease. While cisplatin-based chemoradiotherapy remains the standard-of-care treatment for this patient population, it is still…
- Trial name
- NCT07781072
- Testing
- Hypofractionated Induction RT (5Gy×3) Followed by Sintilimab, Platinum-Based CCRT and Sintilimab
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Esophageal Squamous Cell Carcinoma
A Study of Sintilimab Plus Chemoradiation Before Surgery for Esophageal Cancer
The purpose of this study is to test the the efficacy and safety of sintilimab in combination with chemoradiation before surgery for esophageal cancer.
- Trial name
- NCT03940001
- Testing
- Sintilimab, carboplatin/paclitaxel, Radiation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang Cancer Hospital
Carcinoma Cervix
Study on Early Stage Bulky Cervical Cancers
The aim of this study is to establish the role of neoadjuvant chemotherapy and chemo irradiation in carcinoma cervix and to compare its results with the concurrent chemo irradiation in terms of overall survival, disease free…
- Trial name
- NCT01917695
- Testing
- Chemotherapy, External Beam Radiotherapy, Brachytherapy
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Rajkumar Kottayasamy Seenivasagam
Carcinoma, Non-Small-Cell Lung
Dietary Practices and Locally Advanced Lung Cancer (LUNGDIET)
In recent years, fasting or the use of special diets (ketogenic, high protein, etc.), whether or not associated with food supplements, have increased substantially, particularly in oncology with the idea of improving for some of…
- Trial name
- LUNGDIET (NCT06068088)
- Testing
- Self-administered survey at hospital, Blood sample for nutritional assessment, Consultation with nutritionist doctor and dietician
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nasopharyngeal Carcinoma
Phase III Trial of Concurrent Chemotherapy Alone in Patients With Low-risk Nasopharyngeal Carcinoma
The purpose of this study is to compare concurrent chemoradiotherapy (CCRT) alone with induction chemotherapy (gemcitabine+cisplatin) plus CCRT in patients with low-risk locoregionally advanced nasopharyngeal carcinoma(NPC).
- Trial name
- NCT05979961
- Testing
- IMRT and concurrent cisplatin, gemcitabine and cisplatin (Induction chemotherapy)
- Where
- 8 sites in China
- Volunteers
- 464 people
- Sponsor
- Sun Yat-sen University
Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Preoperative radiotherapy combined with 5-fluorouracil/capecitabine is currently the standard treatment for locally advanced rectal cancer.
- Trial name
- ESTIMATE (NCT06239870)
- Testing
- Envafolimab combined with chemoradiotherapy in the whole course of neoadjuvant therapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Yunnan Cancer Hospital
Head and Neck Cancer
Prediction of Outcome After Chemoradiotherapy for Head and Neck Cancer Using Functional Imaging and Tumor Biology
Despite uniform histopathological definition the response of locally advanced squamous cell carcinomas of the head and neck (HNSCC) to ionizing radiation differs greatly with locoregional recurrences burdening this patient…
- Trial name
- NCT01829646
- Testing
- functional MRI, Hypoxia gene expression profile., Functional MRI before start of treatment.
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophagus Cancer
Radiochemotherapy in Elderly Patients With Oesophagus Cancer
Phase II study of radiochemotherapy for elderly patients with oesophagus cancer.
- Trial name
- Chronos (NCT02879227)
- Testing
- Cisplatin, Oxaliplatin
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Grade II/III Glioma
CCRT With Temozolomide Versus RT Alone in Patients With IDH Wild-type/TERT Promoter Mutation Grade II/III Gliomas
The management of lower-grade gliomas (Diffuse low-grade and intermediate-grade gliomas, WHO II and III) is largely based on surgery followed by radiotherapy.
- Trial name
- NCT02766270
- Testing
- Temozolomide, Radiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Head and Neck Neoplasms, Carcinoma, Squamous Cell
Postoperative Concurrent Chemoradiation for Head and Neck Cancer With Multiple Minor Risk
The purpose of this study is to determine the treatment outcome of postoperative concurrent chemoradiation for head and neck squamous cell carcinoma with multiple minor risks.
- Trial name
- NCT00937612
- Testing
- Radiotherapy
- Where
- 3 sites in Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Locally Advanced Rectal Cancer (LARC)
PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer
This is a single-center, open-label, single-arm clinical study aimed at conducting a preliminary evaluation of the efficacy and safety of combining PCSK9 inhibitors and PD-1 inhibitors (dual inhibitors) with neoadjuvant…
- Trial name
- NCT06933251
- Testing
- Neoadjuvant Chemoradiotherapy Combined with PD-1 inhibitor Immunotherapy and PCSK9 Inhibitor Therapy
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Guangdong Provincial People's Hospital
Pulmonary Neoplasm
Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806)
The purpose of this study is to evaluate the safety and efficacy of the trimodality (concurrent chemoradiotherapy followed by surgical resection) approach in superior sulcus tumors.
- Trial name
- NCT00128037
- Testing
- mitomycin C, vindesine, cisplatin and radiotherapy
- Where
- Japan
- Volunteers
- 75 people
- Sponsor
- Japan Clinical Oncology Group
Rectal Neoplasms
Local Excision in Downstaged Rectal Cancer
Patients with T2T3 low rectal cancer (size =< 4 cm) received neoadjuvant treatment (50Gy in 5 weeks with concomitant chemotherapy.
- Trial name
- GRECCAR 2 (NCT00427375)
- Testing
- local rectal excision, total mesorectal excision
- Where
- 40 sites in France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Bordeaux
Rectal Neoplasms
CONVERT: Neoadjuvant Chemotherapy Alone Versus Preoperative Chemoradiation for Locally Advanced Rectal Cancer Patients
Although neoadjuvant radiotherapy greatly decreases local recurrence in locally advanced rectal cancer patients undergoing surgery, it inevitably results in short-term and long-term toxicities.
- Trial name
- NCT02288195
- Testing
- Oxaliplatin, capecitabine, Radiation
- Where
- China
- Volunteers
- 663 people
- Sponsor
- Sun Yat-sen University
Glioblastoma
A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma
The objectives of this phase I first-in-human trial are to evaluate safety, feasibility, and preliminary efficacy of an individualized Bvax vaccine in addition to standard of care chemoradiation in patients with newly diagnosed…
- Trial name
- Bvax (NCT07422896)
- Testing
- B-cell vaccination
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Catalina Lee Chang
Small Cell Lung Cancer
Phase I Trial of CArbonic Anhydrase Inhibition in Combination With Radiochemotherapy or Radioimmunotherapy in Small Cell Lung Carcinoma
The investigators propose to study the carbonic anhydrase inhibition (acetazolamide) associated with concomitant radiochemotherapy or radioimmunotherapy in small cell lung cancer due to: 1.
- Trial name
- ICAR (NCT03467360)
- Testing
- acetazolamide in combination with platinum and etoposide-based radiochemotherapy, acetazolamide in combination with radioimmunotherapy in patients with extensive SCLC
- Where
- 2 sites in France, Monaco
- Volunteers
- 27 people
- Sponsor
- Centre Antoine Lacassagne
SCLC, Limited Stage
A Phase II Study of Tislelizumab Plus Anlotinib Consolidation After Chemoradiotherapy in LS-SCLC
This prospective, single-arm, phase II study aims to evaluate the efficacy and safety of tislelizumab plus anlotinib as consolidation therapy in patients with limited-stage small cell lung cancer (LS-SCLC) who have not progressed…
- Trial name
- NCT07815223
- Testing
- Tislelizumab + Anlotinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yantai Yuhuangding Hospital
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