Clinical trials: Chemoradiotherapy
Locally Advanced Oesophageal Cancer
Home Monitoring During Chemoradiation
Chemoradiotherapy is part of standard treatment for patients with locally advanced oesophageal cancer. Some patients with oesophageal cancer treated with chemoradiotherapy do not complete treatment due to toxicity, or face…
- Trial name
- AMCOR (NCT06597240)
- Testing
- AMCOR
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Esophageal Carcinoma
A Study to Evaluate the Combination of Cetuximab and Chemotherapy as Neoadjuvant Therapy Followed Concomitant Chemoradiotherapy Plus Cetuximab in Locoregional Esophageal Carcinoma
The purpose of the study is to determine efficacy ans safety of the combination of cetuximab and chemotherapy (docetaxel, cisplatin, 5-fluorouracil) as neoadjuvant therapy followed concomitant chemoradiotherapy (cisplatin) plus…
- Trial name
- NCT00733889
- Testing
- cetuximab and chemotherapy (docetaxel, cisplatin, 5-fluorouracil)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Nasopharyngeal Carcinoma, Neoadjuvant Chemotherapy
A Multicenter, Prospective, Phase III Randomized Controlled Clinical Study for the Treatment of N2-3 Nasopharyngeal Carcinoma Patients
At the initial diagnosis of locally advanced nasopharyngeal carcinoma, a considerable proportion of patients have developed distant metastasis, forming subclinical lesions.
- Trial name
- NCT04061278
- Testing
- 4 cycles of Neoadjuvant Chemotherapy With Definitive Radiotherapy, 3 cycles of Neoadjuvant Chemotherapy With concurrent chemoradiotherapy
- Where
- 12 sites in China
- Volunteers
- 246 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer
Chemoradiation or Brachytherapy for Rectal Cancer
This research is being done to compare the effectiveness of high dose endorectal brachytherapy (END-HDR) and the standard treatment option of chemoradiation with Capecitabine in the treatment of cancer of the lowest part of the…
- Trial name
- CORRECT (NCT02017704)
- Testing
- Endo-HDR (if randomized to this arm), capecitabine and IMRT (if randomized to this arm), IMRT (intensity modulated radiation therapy)
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Esophageal Carcinoma
Concurrent Chemoradiation With or Without DC-CIK Immunotherapy in Treating Locally Advanced Esophageal Cancer
The purpose of this study is to show if the adoptive cellular therapy with autologous dendritic cells and cytokine-induced killer cells (CIK) combined with concurrent chemoradiation could improve the quality of life of the…
- Trial name
- NCT01691625
- Testing
- concurrent chemoradiotherapy plus DC-CIK immunotherapy, Concurrent chemoradiation only
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Capital Medical University
Unresectable Stage III NSCLC
A Study to Evaluate the Safety of Concurrent Durvalumab With CRT Followed by Durvalumab for Chinese Unresectable Stage III NSCLC
This is a prospective, multi-center, single arm study assessing the efficacy and safety of durvalumab given concurrently with platinum-based CRT (durvalumab + SoC CRT) in patients with locally advanced, unresectable NSCLC (Stage…
- Trial name
- NCT04982549
- Testing
- Durvalumab, Carboplatin/ Paclitaxel, Pemetrexed/ Cisplatin
- Where
- 2 sites in China
- Volunteers
- 35 people
- Sponsor
- Shandong Cancer Hospital and Institute
Locally Advanced Rectal Cancer (LARC)
Serine/Glycine-Restricted Diet With Chemoradiotherapy for Rectal Cancer
This is a Phase Ib/II seamless, open-label, randomized controlled trial evaluating the safety and efficacy of a serine/glycine-restricted diet combined with neoadjuvant chemoradiotherapy and immunotherapy in patients with locally…
- Trial name
- SG-RCT (NCT07811076)
- Testing
- Serine/Glycine-Restricted Diet, CAPOX Chemotherapy, PD-1 Inhibitor
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Xuelei Ma MD
LOCALLY ADVANCED CERVICAL CANCERS
A Single-Arm Exploratory Study of Enlansibumab Sequentially Combined With Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer
This is a prospective , single - arm clinical study , aiming to evaluate the efficacy and safety of Enlansibumab sequential concurrent chemoradiotherapy in locally advanced cervical cancer.
- Trial name
- NCT06981858
- Testing
- Enlonstobart Injection
- Volunteers
- 34 people
- Sponsor
- Chongqing University Cancer Hospital
Invasive Breast Cancer, Stage III Breast Cancer
Postoperative Radiotherapy in Breast Cancer- Concurrent or Sequential With Chemotherapy
This clinical research aims to determine if concurrent chemotherapy and radiation therapy is more effective than sequential chemotherapy and radiation therapy for patients with stage IIB-III breast cancer.
- Conditions
- Invasive Breast Cancer, Stage III Breast Cancer, Stage IIB Breast Cancer
- Trial name
- CONCERT (NCT06926543)
- Testing
- Chemoradiation
- Where
- 5 sites in India
- Volunteers
- 858 people
- Sponsor
- Dr. Tabassum Wadasadawala
Esophageal Neoplasm
Response Prediction to Neoadjuvant Chemoradiation in Esophageal Cancer Using Artificial Intelligence & Machine Learning
In esophageal carcinoma, neoadjuvant concurrent chemo-radiotherapy (NA-CCRT) followed by surgery is the current standard of care and ample evidence has accumulated supporting the view that complete pathological response (pCR) is…
- Trial name
- QARC (NCT04489368)
- Testing
- Neo-Adjuvant Radiotherapy, Neo-Adjuvant Chemotherapy, Esophagectomy
- Where
- 2 sites in Australia, India
- Volunteers
- 150 people
- Sponsor
- Dr Kundan Singh Chufal
Rectal Cancer
Relationship Between Lymph Node Ratio and Survival Rate in Preoperative Chemoradiation Rectal Cancer Patients
Colorectal cancer is the most-common cancer of the gastrointestinal tract. The number of positive lymph nodes and total number of lymph nodes retrieved are important prognostic factors.
- Trial name
- NCT04096118
- Where
- Thailand
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Squamous Cell Carcinoma of Oropharynx, Squamous Cell Carcinoma of the Hypopharynx
Immune Biomarker Study for Cisplatin-ineligible Patients Receiving Chemoradiotherapy With Docetaxel
Analysis of tumor tissue (which is already available in pathology) and collection of saliva/stool and blood samples, which are obtained as part of a routine collection.
- Conditions
- Squamous Cell Carcinoma of Oropharynx, Squamous Cell Carcinoma of the Hypopharynx, Larynx Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma
- Trial name
- DoIT_Neck (NCT06947668)
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Dysphagia, Lung Cancer
Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer
RATIONALE: Manuka honey may prevent or reduce esophagitis-related pain caused by chemotherapy and radiation therapy. It is not yet known whether Manuka honey is more effective than standard care in preventing pain.
- Conditions
- Dysphagia, Lung Cancer, Pain, Esophagitis
- Trial name
- NCT01262560
- Testing
- Manuka honey in liquid form, Manuka honey in lozenge form, Standard supportive care
- Where
- 59 sites in United States
- Volunteers
- 163 people
- Sponsor
- Radiation Therapy Oncology Group
Rectal Cancer
Timing to Minimally Invasive Surgery After Neoadjuvant Chemoradiotherapy for Rectal Cancer
The trial is a multicenter, prospective, randomized controlled, unblinded, parallel-group trial comparing standard and delayed surgery after neoadjuvant chemoradiotherapy for the curative treatment of rectal cancer.
- Trial name
- TiMiSNAR (NCT03465982)
- Testing
- Surgery after 8 weeks from chemoradiation treatment, Surgery after 12 weeks from chemoradiation treatment
- Where
- 14 sites in Italy
- Volunteers
- 340 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Primary Central Nervous System Lymphoma
a Phase II Study in Primary Central Nervous System Lymphoma
In this study we will test the hypothesis that concurrent chemoradiation (CCRT) with temozolomide after induction chemotherapy by conventional high-dose methotrexate (HD-MTX) plus dexamethasone may be an effective and well…
- Trial name
- NCT00455286
- Testing
- Methotrexate, Methylprednisolone, Temozolomide
- Where
- 4 sites in Taiwan
- Volunteers
- 25 people
- Sponsor
- National Health Research Institutes, Taiwan
Colorectal Neoplasms
Neoadjuvant Chemoradiotherapy Plus Tislelizumab Followed by TME for LARC.
Long course radiotherapy plus neoadjuvant chemotherapy followed by resection total mesorecta excision has accepted widespread recognized in the treatment of locally advanced rectal cancer (LARC).
- Trial name
- NCT04911517
- Testing
- long course radiotherapy + capecitabine + PD-1 monoclonal antibody treatment combinations
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Friendship Hospital
Esophageal Carcinoma
Serplulimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age
This study is a Single Arm, Prospective, Exploratory, Single Center Phase II Clinical Study to evaluate the effectiveness of the combination of Serplulimab and Concurrent Chemoradiotherapy in the treatment of elderly patients…
- Trial name
- NCT06354218
- Testing
- Serplulimab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Small Cell Lung Carcinoma
Adebrelimab and Concurrent Radiochemotherapy as First-line Treatment for Extensive-stage Small-cell Lung Cancer
Patients with extensive-stage small-cell lung cancer (ES-SCLC) have poor prognosis, with limited treatment options. Chemo-immunotherapy is the standard 1st-line therapy for patients with ES-SCLC.When 4 cycles of…
- Trial name
- NCT06236997
- Testing
- Adebrelimab, Radiation Therapy, etoposide, carboplatin(EC)
- Where
- 2 sites in China
- Volunteers
- 48 people
- Sponsor
- Henan Cancer Hospital
Esophageal Squamous Cell Carcinoma
Adjuvant Pembrolizumab for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma at High Risk of Recurrence
In this study, participants with histologically diagnosed locally advanced esophageal squamous cell carcinoma who have received preoperative cisplatin-based chemoradiotherapy followed by surgery harbouring high risk of tumor…
- Trial name
- NCT03322267
- Testing
- Pembrolizumab
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- National Taiwan University Hospital
High Risk Cervical Cancer, Advanced Cervical Cancer
Study of ADXS11-001 in Participants With High Risk Locally Advanced Cervical Cancer
Locally advanced cervical cancer at higher risk for recurrence (HRLACC) following concurrent chemotherapy and radiation therapy. This is a group of participants with a significant unmet need.
- Trial name
- AIM2CERV (NCT02853604)
- Testing
- ADXS11-001
- Where
- 117 sites in United States, Argentina and 12 more
- Volunteers
- 110 people
- Sponsor
- Advaxis, Inc.
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