Clinical trials: Chiari Malformation
Syringomyelia, Arnold Chiari Deformity
A Prospective Natural History Study of Patients With Syringomyelia
Background: Syringomyelia is a disorder in which a cyst (syrinx) forms within the spinal cord and causes spinal cord injury, with symptoms worsening over many years, including paralysis, loss of sensation, and chronic pain.
- Trial name
- NCT01150708
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Arnold-Chiari Malformation, Type 1, Chiari Malformation Type I
Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia
The purpose of this study is to determine whether a posterior fossa decompression or a posterior fossa decompression with duraplasty results in better patient outcomes with fewer complications and improved quality of life in…
- Conditions
- Arnold-Chiari Malformation, Type 1, Chiari Malformation Type I, Type I Arnold-Chiari Malformation, Syringomyelia
- Trial name
- NCT02669836
- Testing
- Posterior fossa decompression, Dural Augmentation
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Washington University School of Medicine
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Syringomyelia, Chiari Malformation
Development of a Patient-reported Outcome Measure for Chiari Malformation and Syringomyelia
Chiari malformation corresponds to the herniation of cerebellar tonsils into the foramen magnum resulting in obstruction of cerebrospinal fluid circulation, which may eventually lead to the formation of an intramedullary cavity…
- Trial name
- BCS-score (NCT06011226)
- Testing
- focus groups, questionnaire
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chiari Malformation Type I
Health-related Quality of Life in Chiari Malformation Type 1 - A National Cross-Sectional Patient Survey
The goal of this observational survey study is to investigate factors that may affect the health-related quality of life (HRQoL) in adults with Chiari malformation type 1 (CM1).
- Trial name
- NCT07818122
- Where
- Sweden
- Volunteers
- 1,004 people
- Sponsor
- Karolinska Institutet
Arnold Chiari Malformation
Investigation of the Effects of Exercise Program in Patients With Chiari Type 1 Malformation
This study will be conducted in Hacettepe University Faculty of Medicine Neurosurgery Department and Hacettepe University Faculty of Physical Therapy and Rehabilitation. The study was designed as a randomized controlled trial.
- Trial name
- NCT04073667
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people
- Sponsor
- Hacettepe University
Chiari Malformation
Duragen Versus Duraguard in Chiari Surgery
The study evaluates two materials used for duraplasty of the posterior cranial fossa in treatment of Chiari malformation. One material (DuraGen) is a non-suturable collagen matrix that is applied over the defect if brain…
- Trial name
- NCT00741858
- Testing
- Duragen duraplasty, Duraguard duraplasty
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Illinois Chicago
Chronic Pain, Chiari Malformation
Online Acceptance and Commitment Therapy for Chronic Pain in Sample of People With Chiari Malformation
Twenty percent of US adults report chronic pain symptoms. Both psychological symptoms and sleep issues commonly co-occur with chronic pain.
- Trial name
- NCT04089670
- Testing
- Online Acceptance and Commitment Therapy Intervention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Kent State University
Neural Tube Defects, Spina Bifida
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized.
- Conditions
- Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation
- Trial name
- NCT03856034
- Testing
- Fetoscopy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- USFetus
Chiari Malformation
Dural Graft Equivalent Comparison Trial
This research study is to find out which types of dural grafts used during surgery for Chiari Malformations are superior. We believe that autologous dural grafts are superior to non-autologous grafts.
- Trial name
- DECOMPRESS (NCT01667770)
- Testing
- decompression of Chiari malformation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Type I Chiari Malformation, Cerebral Hemodynamic
Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari Malformations
A global analysis of craniospinal hemodynamics and hydrodynamics is necessary to better understand the pathophysiology of Chiari malformations.
- Conditions
- Type I Chiari Malformation, Cerebral Hemodynamic, Craniospinal Hydrodynamic, Phase Contrast MRI
- Trial name
- NEUROFLUX-C (NCT06502431)
- Testing
- phase contrast sequences
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chiari Type I Malformation
The Genetics of Chiari Type I Malformation
Duke University Medical Center is investigating the hereditary basis of Chiari type I malformations with or without syringomyelia (CM1/S).
- Trial name
- NCT01060800
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Meningioma, Tumor, Brain
MiDura-Study (Neuro-Patch in Duraplasty)
The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer
- Conditions
- Meningioma, Tumor, Brain, Chiari Malformation, Vascular Malformation
- Trial name
- MiDura (NCT04189172)
- Where
- 4 sites in France, Germany
- Volunteers
- 328 people
- Sponsor
- Aesculap AG
Fetal Anomaly, Spinal Dysraphism
An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience
Brain stem and posterior fossa measurements in spina bifida aperta fetuses to compare them with normal population. Additionally, Describe the difference between pre- and postoperative findings.
- Conditions
- Fetal Anomaly, Spinal Dysraphism, Chiari Malformation Type 2
- Trial name
- NCT03544970
- Where
- Belgium
- Volunteers
- 316 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spina Bifida, Myelomeningocele
Fetoscopic Repair of Isolated Fetal Spina Bifida
The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital.
- Conditions
- Spina Bifida, Myelomeningocele, Chiari Malformation Type 2, Neural Tube Defects
- Trial name
- NCT03090633
- Testing
- Fetoscopy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Atlantoaxial Dislocation, Chiari Malformation
Clinical Study of the Treatment of Chiari Malformation Combined With Type II Skull Base Depression
The research background of this study is that Chiari malformation (CM) is a congenital malformation in the foramen magnum region, often associated with syringomyelia, basilar depression, odontoid dislocation and other…
- Conditions
- Atlantoaxial Dislocation, Chiari Malformation, Basilar Invagination
- Trial name
- NCT05754554
- Testing
- Atlas occipital decompression lateral joint release combined with occipital-neck fusion, Simple FMD with Outer Dural Delamination
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Southern Medical University, China
Chiari Malformation Type I, Proprioceptive Disorders
Investigation of the Effects of Exercise on Patients With Chiari Malformation
Chiari Malformation (CM) is a posterior brain anomaly caused by the displacement of the brain stem and cerebellum into the cervical spinal canal.
- Conditions
- Chiari Malformation Type I, Proprioceptive Disorders, Coordination and Balance Disturbances, Syringomyelia
- Trial name
- NCT04220541
- Testing
- Motor learning based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Hacettepe University
Chiari Malformation, Type 1
Modalities of Surgical Treatment of Chiari Malformation Disease : Clinical Study and Outcomes
Evaluation of postoperative outcomes of Chiari type I Malformation Patients at Department of Neurosurgery Assiut University Hospital .
- Trial name
- NCT06029101
- Testing
- posterior fossa craniectomy with or without duraplasty
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Assiut University
Organic Obstructive Sleep Apnea (Diagnosis), Questionnaire
Comparison of Four Questionnaires for OSA Screening in China
Background: Obstructive sleep apnea (OSA) refers to the apnea and hypopnea caused by upper airway obstruction during sleep. Patients are associated with sleep disorders, frequent desaturation, hypertension, coronary heart…
- Conditions
- Organic Obstructive Sleep Apnea (Diagnosis), Questionnaire, Chiari Malformation
- Trial name
- COQ (NCT03074747)
- Testing
- questionnaires
- Volunteers
- 1,200 people
- Sponsor
- Beijing Tongren Hospital
Neural Tube Defects, Spina Bifida, Open
Fetal Endoscopic Surgery for Spina Bifida
This study aims to assess the feasibility to perform a fetoscopic prenatal repair of an open neural tube defect, and secondly to assess the maternal, fetal and neonatal outcomes.
- Conditions
- Neural Tube Defects, Spina Bifida, Open, Myelomeningocele, Fetal Disease
- Trial name
- FESSB (NCT03315637)
- Testing
- Fetoscopic repair of spina bifida
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute