Clinical trials: Child Malnutrition
Infant Malnutrition, Cognitive Change
Integrating Infant Feeding Counselling With Psychosocial Stimulation to Improve Child Growth and Development in Urban Slum of Bangladesh
Undernutrition and poor cognitive development affect many children under 5 in developing countries, who are exposed to multiple risk factors including poverty, malnutrition, poor health, and unstimulating home environments.
- Trial name
- NCT03040375
- Testing
- Peer counselling
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Hypophosphatasia
Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)
This clinical trial was conducted to study hypophosphatasia (HPP), a bone disorder caused by gene mutations or changes. These gene mutations cause low levels of an enzyme needed to harden bone.
- Trial name
- NCT01176266
- Testing
- asfotase alfa
- Where
- 23 sites in United States, Australia and 10 more
- Volunteers
- 69 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Weight Gain, Body Mass Index
"Effects of High-Calorie Diets VS High-Calorie Formulas on Weight Gain in Children With Congenital Heart Disease "
This study is a randomized controlled trial designed to evaluate the effects of high-calorie diets and specialized nutritional formulas on weight gain and clinical outcomes in underweight children aged 1 to 5 years with…
- Conditions
- Weight Gain, Body Mass Index, Pediatric Nutrition, Congenital Heart Disease
- Trial name
- NCT07552688
- Testing
- High-Calorie Specialized Nutritional Formula, education program, High-Calorie Diet
- Where
- 2 sites in Iraq
- Volunteers
- 75 people
- Sponsor
- Aryan Najmadin Nasradin
Severe Wasting, Severe Acute Malnutrition
High-protein Quantity and Quality RUTF in Improving Linear Growth Among Children With Severe Wasting
This is a proof-of-concept trial that aims to compare the efficacy of an 8-week treatment with higher-protein-Ready-to-Use Therapeutic Foods (RUTF) with standard RUTF in improving levels of markers of growths, height, nutritional…
- Trial name
- Protein+ (NCT05737472)
- Testing
- High-protein RUTF, Standard RUTF
- Where
- Malawi
- Volunteers
- 128 people
- Sponsor
- The Hospital for Sick Children
Intestinal Failure, Short Bowel Syndrome
Safety and Dosing Study of Glucagon-like Peptide 2 (GLP-2) in Infants and Children With Intestinal Failure
This protocol outlines a randomized,open label trial examining the safety, pharmacology and efficacy of Glucagon like peptide 2 (GLP-2) in infants and children with intestinal failure.
- Trial name
- GLP-2-01 (NCT01573286)
- Testing
- Glucagon-Like Peptide 2, Glucagon like peptide-2
- Where
- 4 sites in Canada
- Volunteers
- 13 people
- Sponsor
- Alberta Children's Hospital
Malnutrition, Infant, Malnutrition, Child
Efficacy of Mobile Health Application in Promotion of Exclusive Breast Feeding and Young Child Feeding Practices in Pakistan
Early life nutrition is the key modifiable determinant of child growth, development, survival and diseases of adult onset. Pakistan ranks highest for neonatal mortality rate (44.2/1000 live births (LBs)) globally.
- Trial name
- NCT05590351
- Testing
- First diet: m-health coaching application, Face to Face counselling
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Environmental Enteric Dysfunction, Zinc Deficiency
Effects of EED on Zn Absorption and Retention in Children From a Standard Dose
The overall objective is to determine the impact of EED on zinc absorption and homeostasis, and its impact on the absorptive capacity of vitamin A absorption of young children (18-24 months of age) in an austere setting with high…
- Conditions
- Environmental Enteric Dysfunction, Zinc Deficiency, Vitamin A Deficiency
- Trial name
- ZEED1 (NCT02760095)
- Testing
- 3 mg zinc sulfate supplement, 0.5 mg of 13C10-retinyl-acetate
- Where
- 2 sites in United States, Bangladesh
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Anemia, Iron-deficiency
The Effect of Anemia in Infancy on the Microbiome and Systemic Metabolism
Serum and fecal samples were collected from infants at either 6-7 m of age or 12-13 m of age. Serum and feces were analyzed locally for hemoglobin status or evidence of parasites, and standard of care was provided.
- Conditions
- Anemia, Iron-deficiency, Iron Deficiency Anemia
- Trial name
- NCT03377777
- Testing
- No intervention
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Malnutrition, Infection
Effectiveness of Supplementary Feeding During Infection Among Moderately Malnourished Children
The purpose of this study is to determine whether an outpatient-based strategy of short-term, ready to use supplementary food (RUSF) among moderately malnourished children with acute infections achieves greater improvement in…
- Trial name
- MODMAL (NCT00890695)
- Testing
- Ready to use supplementary food (RUSF)
- Where
- 2 sites in Kenya
- Volunteers
- 64 people
- Sponsor
- University of Oxford
Malnutrition, Child Development
Tools to Improve Parental Recognition of Developmental Deficits in Children
In this study, we aim to improve child nutrition by increasing parents' awareness of their children's physical growth. We use a cluster-randomized trial design to evaluate two interventions that provide parents with regular…
- Trial name
- NCT02242539
- Testing
- Height measurement poster, Community-based monitoring
- Where
- Zambia
- Volunteers
- 547 people, healthy volunteers welcome
- Sponsor
- Boston University
Tumor, Solid, Children
Standardized Nutritional Management of Pediatric Patients With Solid Tumors
The purpose of this study is to establish a standardized nutrition intervention procedure for children with solid tumors, and to explore the effectiveness and clinical applicability of standardized nutrition management and short…
- Conditions
- Tumor, Solid, Children, Nutritional Intervention
- Trial name
- NCT06730204
- Testing
- Standardized nutritional management, Standardized nutritional management + short peptide ONS
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Children's Hospital of Fudan University
Malnutrition
Efficacy Trial on Alleviation of Infant Malnutrition With Fortified Spread or Maize-soy Flour Food Supplements
This study tests the hypothesis that moderately underweight but not severely wasted 6-17-month old infants receiving fortified spread or maize-soy flour as a food supplement for 12 weeks grow better during the supplementation…
- Trial name
- NCT00420368
- Testing
- No food supplement, Food supplement: fortified spread, Food supplement: maize-soy flour
- Where
- Malawi
- Volunteers
- 189 people
- Sponsor
- Tampere University
Malnutrition
Assessment of the Nutritional Status of Children and Adolescents With Malignancies
The main objective of this study was the assessment of the nutritional status of children and adolescents aged between 0-18 with malignancies based on BMI percentiles and standard deviation scores, at diagnosis, during treatment…
- Trial name
- NCT02246452
- Volunteers
- 135 people
- Sponsor
- University of Hohenheim
Malnutrition, Child
Effect of an Alternative RUTF on Intestinal Permeability in Children With Severe Acute Malnutrition
Ready-to-use therapeutic food (RUTF) is the standard of care for the treatment of SAM. UNICEF requires that there be no oil separation in these products necessitating the use of emulsifiers.
- Trial name
- NCT04334538
- Testing
- S-RUTF, oat RUTF
- Where
- Sierra Leone
- Volunteers
- 129 people
- Sponsor
- Washington University School of Medicine
Malnutrition, Child
Impact of Harvest Lentil Vegetable Blend and Nutrition Education on Turkana Children's Health Outcomes
The goal of this study was to test the effect of an intervention that Integrated supplemental feeding program for children aged 6-59 months with a caregiver intensive nutrition education intervention on the health outcomes of…
- Trial name
- NCT06866626
- Testing
- Theory-Based Nutrition Education Intervention to Improve Infant and Young Child Feeding Practices and WASH Practices Among Turkana Caregivers, Harvest Lentil Vegetable Blend
- Where
- Kenya
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Water-Related Diseases
SAFEWATER Health & Behaviour Impact Field Trials; Colombia
At least 1.8 billion people globally use a source of drinking water that is faecally contaminated and thus likely to lead to diarrheal illness: nearly 1,000 children die each day due to water and sanitation-related diarrhoeal…
- Trial name
- SAFEWATER (NCT04829981)
- Testing
- SAFEWATER systems for drinking water disinfection, Behaviour change interventions
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Undernutrition
Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children
Nutrition is essential for a child's growth, brain development, and protection from disease. While breastmilk provides the best nutrition for young infants, children older than six months may not get all the nutrients they need…
- Trial name
- NCT07451951
- Testing
- Medium-quantity lipid-based nutrient supplement (MQ-LNS), Small-quantity lipid-based nutrient supplement (SQ-LNS)
- Where
- 2 sites in Pakistan
- Volunteers
- 1,568 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Lead Poisoning, Vitamin D Deficiency
Penicillamine Chelation for Children With Lead Poisoning
Childhood Lead Poisoning is a widespread disease that has few effective treatments. The specific aims of this proposed clinical trial are threefold: To determine whether a six-week course of a newly formulated d-penicillamine…
- Trial name
- NCT00552630
- Testing
- d-penicillamine
- Where
- United States
- Sponsor
- FDA Office of Orphan Products Development
Crohn Disease Colitis, Colitis, Ulcerative
Resting Energy Expenditure in Pediatric Patients With Inflammatory Bowel Disease (REE-MICI)
This multicenter prospective observational non-pharmacological study aims to evaluate resting energy expenditure (REE) in pediatric patients affected by inflammatory bowel disease (IBD), including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease Colitis, Colitis, Ulcerative, Inflammatory Bowel Diseases
- Trial name
- REE-MICI (NCT07670975)
- Testing
- Indirect Calorimetry
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Primary Malnurtrition
Folic Acid Supplementation as an Appetizer in Primary Malnourished Egyptian Infants and Children
Folic acid as a appetizer in primary malnutrition
- Trial name
- NCT03040219
- Testing
- Folic Acid
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University