Clinical trials: Childhood Pneumonia
Pneumonia, Bacterial, Viral Infection
Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia
Clinical pneumonia is a leading cause of pediatric hospitalization. The etiology is generally bacterial or viral. Prompt and optimal treatment of pneumonia is critical to reduce mortality.
- Conditions
- Pneumonia, Bacterial, Viral Infection, Clinical Pneumonia, Plasmodium Falciparum Malaria
- Trial name
- NCT03996967
- Where
- 3 sites in United States, Netherlands and 1 more
- Volunteers
- 837 people
- Sponsor
- Boston University
Pneumonia Childhood
The Role of Melatonin as an Adjuvant Therapy in Childhood Pneumonia
The goal of this study is to compare the mean length of hospital stay between children with pneumonia receiving melatonin as an adjuvant therapy and those receiving standard of care alone.
- Trial name
- NCT06949904
- Testing
- Melatonin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mian Muhammad Hassan Ahmed
Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs)
Validation of the EQ-5D-Y-3L and EQ-5D-Y-5L for Paediatric Patients in China
The goal of this observational study is to validate the EQ-5D-Y-3L and EQ-5D-Y-5L in measuring health-related quality of life (HRQoL) for paediatric patients with different health conditions in China.
- Conditions
- Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs), Pneumonia Childhood, Neuroblastoma (NB)
- Trial name
- NCT06873672
- Where
- China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Childhood Diarrhea, Childhood Pneumonia
Community Mobilization and Incentivization for Childhood Diarrhea and Pneumonia
Childhood diarrhea and pneumonia remains the leading cause of mortality among children under five years of age in Pakistan. The prevalence of diarrhea in Pakistan has increased from 15% in 1990 to 23% in 2013 while there has been…
- Conditions
- Childhood Diarrhea, Childhood Pneumonia, Community Mobilisation, Sanitation and Hygiene
- Trial name
- CoMIC (NCT03594279)
- Testing
- Community Mobilization, Community Mobilization and Community Incentive
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Aga Khan University
Cancer
Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation
RATIONALE: Antivirals such as ribavirin are used to treat infections caused by viruses. It is not yet known if ribavirin is more effective with or without monoclonal antibody therapy in treating patients who develop RSV pneumonia…
- Trial name
- NCT00014391
- Testing
- palivizumab, ribavirin
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Community Acquired Pneumonia, Childhood Pneumonia
3 vs. 5 Days of Amoxicillin for Childhood Pneumonia: An RCT
Pneumonia is the most common infection in children and leading to most common cause of mortality and morbidity in in children globally. Bacterial cause is mostly streptococcus pneumonia in children of 3 months to 5 years of age.
- Trial name
- Pnemonia (NCT07647835)
- Testing
- Amoxicillin
- Where
- Pakistan
- Volunteers
- 250 people
- Sponsor
- Khyber Teaching Hospital
Childhood Obesity
Evaluation of an Online Lifestyle Intervention in Mexican School Children During COVID-19 Pandemic
Introduction: School closures due to the COVID-19 pandemic represent a risk factor for the development of childhood obesity due to the increase in unhealthy behaviors.
- Trial name
- NCT04772859
- Testing
- Online Lifestyle Intervention, Control Group
- Where
- Mexico
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidad de Sonora
Empyema, Pneumonia
Urokinase Versus Video-assisted Thoracoscopic to Treat Complicated Parapneumonic Empyema in Childhood
A great controversy exists about which is the best method to perform the evacuation of the collection. The purpose of this study is to evaluate which is the best initial treatment to drain complicated parapneumonic empyema…
- Trial name
- NCT00798278
- Testing
- Urokinase, Video-Assisted Thoracoscopic
- Where
- 6 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Pediatric Surgery
Pneumonia, Childhood Pneumonia
Online Learning Portal on Under Five Pneumonia
Despite the availability of standard pneumonia management guidelines and multiple global efforts, pneumonia continues to be the leading killer of children under five, accounting to around 17% of the total under five deaths…
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT04495361
- Testing
- E-learning portal
- Where
- Pakistan
- Volunteers
- 600 people
- Sponsor
- University of Edinburgh
COVID-19, Childhood Cancer
COVID-19 and Childhood Cancer
The investigators will first examine the impact of the COVID-19 pandemic on childhood cancer patients in Sweden and Denmark, both regarding susceptibility to severe COVID-19 among long-term childhood cancer survivors, and, for…
- Conditions
- COVID-19, Childhood Cancer, Childhood Leukemia, Acute Lymphoblastic
- Trial name
- NCT06482281
- Where
- Sweden
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Childhood Anxiety Disorder, Childhood Depression
Brief Internet-delivered Intervention for Children and Adolescents With Anxiety and Depression Symptoms
Investigators developed a brief standardized internet-delivered cognitive-behavioral program for treating anxious and depressive symptoms in children and adolescents in the context of COVID-19 pandemics in Brazil.
- Trial name
- NCT05139433
- Testing
- Telepsychotherapy, Psychoeducational Videos
- Where
- Brazil
- Volunteers
- 280 people
- Sponsor
- University of Sao Paulo
Pneumonia, Hypoxemia
Solar Oxygen Study
Globally, approximately 7.7 million children per year die before the age of 5 years. Infectious diseases account for a large proportion of these deaths, with pneumonia being the leading cause of mortality (2.1 million…
- Trial name
- SOS (NCT03851783)
- Testing
- Solar-powered oxygen
- Where
- 20 sites in Uganda
- Volunteers
- 2,405 people
- Sponsor
- University of Alberta
Pneumonia, Primary Health Care
Tools for the Integrated Management of Childhood Illness (TIMCI): Evaluation of Pulse Oximetry & Clinical Decision Support Algorithms in Primary Care
By introducing pulse oximetry, with or without clinical decision support algorithms, to primary care facilities in India, Kenya, Senegal and Tanzania, the Tools for Integrated Management of Childhood Illness (TIMCI) project aims…
- Conditions
- Pneumonia, Primary Health Care, Child Health, Hypoxia
- Trial name
- TIMCI (NCT04910750)
- Testing
- Pulse oximetry, Clinical Decision Support Algorithm
- Where
- 27 sites in Tanzania
- Volunteers
- 167,517 people
- Sponsor
- Swiss Tropical & Public Health Institute
Anxiety Disorder of Childhood or Adolescence
Mental Health Support for SickKids Children and Families During COVID-19 Using Established eHealth Interventions
Coronavirus disease 2019 (COVID-19) and associated emergency measures (EM) have dramatically impacted the lives of children/adolescents (children) and families.
- Trial name
- NCT04408027
- Testing
- Virtual-Care Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children
Pneumonia, Childhood Pneumonia
Diagnostic Accuracy of Lung Ultrasound for Pneumonia Diagnosis in Children
Chest X-ray is historically being used as an imaging standard to aid to the diagnosis of childhood pneumonia, however, the evidence does not support it as a perfect imaging tool.
- Trial name
- LUS (NCT07331311)
- Testing
- LUS as a chest imaging tool
- Where
- Nepal
- Volunteers
- 320 people
- Sponsor
- Nagasaki University
Pneumonia
Effect of Enhanced Feedback to Hospitals in an Emerging Clinical Information Network
A cluster randomised pragmatic trial will be conducted within an emerging clinical information network composed of 12 Kenyan county hospitals.
- Trial name
- NCT02817971
- Testing
- Enhanced feedback, Standard feedback
- Where
- 12 sites in Kenya
- Volunteers
- 900 people
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Childhood Pneumonia, Pneumococcal Carriage
The Study of Chest Infections in Infants Living in a Refugee Camp on the Thai-Burmese Border
This study will follow 1000 refugee infants from birth for two years. The aim of the study is to better understand why some children develop infections caused by the bacterium Streptococcus pneumoniae whilst others merely carry…
- Trial name
- ARI (NCT00894764)
- Where
- 2 sites in Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pneumonia Childhood
Severe Pneumonia Diagnostic in Pediatric Population by Lung Ultrasonography and Procalcitonin
Lung ultrasound (LUS) in combination with a biomarker has not yet been studied. The investigators propose a clinical trial where the primary aims are: 1.
- Trial name
- PROLUSP (NCT04217980)
- Testing
- Lung ultrasonography (LUS) or Chest X ray (CXR)
- Where
- 2 sites in Spain
- Volunteers
- 202 people
- Sponsor
- Fundació Sant Joan de Déu
Pneumonia
Host Response and Pathogen Genomics in Childhood Respiratory Infection
A major challenge in children's infections is that it is difficult to work out which bug is making them unwell. Tests can find the bugs that are present though there can be more than one.
- Trial name
- INTERACT (NCT07545096)
- Testing
- Non-Interventional Study
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Feasibility
Feasibility and Acceptability Followed by Effectiveness of bCPAP for Treatment of Bangladeshi Children With Severe Pneumonia
Background: Feasibility and acceptability of bubble continuous positive airway pressure (CPAP) were not evaluated in childhood severe pneumonia in developing countries at a larger scale. Objective: 1.
- Trial name
- Child-bCPAP (NCT05239559)
- Testing
- Bubble CPAP oxygen delivery device
- Where
- 2 sites in Bangladesh
- Volunteers
- 20 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh