Clinical trials: Chlamydia Infections
Trachoma
Azithromycin Reduction to Reach Elimination of Trachoma
The investigators propose a randomized controlled trial of discontinuation versus continuation of annual mass azithromycin distribution in hypoendemic communities of Maradi, Niger.
- Trial name
- ARRET (NCT04185402)
- Testing
- Azithromycin
- Where
- Niger
- Volunteers
- 3,931 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Vaginal Discharge, Sexually Transmitted Diseases
Point-of-care Tests for Vaginal Discharge in Nepal
The goal of this clinical trial is to examine if and how the implementation of point-of care-tests (POCT) for sexually transmitted infections in the management of abnormal vaginal discharge reduces the overtreatment with…
- Trial name
- POCT-BRA (NCT05977491)
- Testing
- Health care practitioner is informed of POCT results for CT and NG, Health care practitioner is informed about POCT result for TV and BV, addressing psycholsocial problems
- Where
- Nepal
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Sexually Transmitted Infection (STI), Gonorrhea
A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women
This study is for people who may get sexually transmitted infections (STIs). Approximately 580 African adolescent and young adult women ages 13-34 in Africa will be included in this study.
- Conditions
- Sexually Transmitted Infection (STI), Gonorrhea, Syphilis, Chlamydia
- Trial name
- NCT07884240
- Testing
- Doxycycline hyclate, Standard of Care for STI prevention
- Where
- 4 sites in Botswana, Eswatini and 2 more
- Volunteers
- 580 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis, Vaginal Microbiome
Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
HIV remains a global pandemic with 37 million infected. In western Kenya, 16% of women in the general population and 29% of the poorest women have HIV.
- Conditions
- Bacterial Vaginosis, Vaginal Microbiome, Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
- Trial name
- POWWERHealth (NCT05666778)
- Testing
- Menstrual Cup
- Where
- 2 sites in United States, Kenya
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
HIV, Syphilis
Texting Intervention to Sustain HIV Prevention in Women in High-drug-use Contexts
The purpose of this study is to determine whether a program of regular, theory-based text messages that encourages the message recipient to continue practicing safer sex (i.e., using condoms with sex partners) is effective in…
- Conditions
- HIV, Syphilis, Gonorrhea, Chlamydia
- Trial name
- NCT02447484
- Testing
- Mujer Segura Siempre, General Health Message Texts
- Where
- Mexico
- Volunteers
- 600 people
- Sponsor
- University of California, San Diego
Sexually Transmitted Diseases, Syphilis
Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro
The goal of this clinical trial is to learn if doxycycline post-exposure prophylaxis (doxy-PEP) can help prevent bacterial sexually transmitted infections (STIs) among sexual and gender minorities in Rio de Janeiro, Brazil…
- Conditions
- Sexually Transmitted Diseases, Syphilis, Gonorrhea, Chlamydia Infections
- Trial name
- NCT07500415
- Testing
- Doxycycline
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Trachoma
Partnership for Rapid Elimination of Trachoma
Trachoma, an ocular infection caused by C. trachomatis, is the second leading infectious cause of blindness worldwide. Years of repeated infection with C.
- Trial name
- PRET (NCT00792922)
- Testing
- Azithromycin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis
Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers
In the early years of the HIV epidemic in Africa, female sex workers (FSWs) were identified as a high-prevalence, high-incidence, core group among whom the extraordinary prevalence of other sexually transmitted infections (STIs)…
- Conditions
- Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis, HIV
- Trial name
- NCT01329588
- Testing
- Monthly antibiotic
- Where
- Benin
- Volunteers
- 636 people
- Sponsor
- CHU de Quebec-Universite Laval
Gonococcal Infection, Chlamydia Infections
Screening of Gonococcal and Chlamydial Infections in the Third Trimester
Untreated maternal infection with gonorrhea and/or chlamydia can have serious complications in pregnancy and the neonatal period.
- Trial name
- NCT03073538
- Volunteers
- 1,691 people
- Sponsor
- Unity Health Toronto
Chlamydia Trachomatis Infection
Transmission of Genital and Extra-genital Chlamydia Trachomatis Infections in Women
Multicenter prospective cohort study in Chlamydia trachomatis positive women after regular treatment to understand the transmission of anorectal CT infections.
- Trial name
- FemCure (NCT02694497)
- Testing
- Chlamydia care as usual
- Where
- Netherlands
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
Multiple Sclerosis
Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory, demyelinating disease which affects the central nervous system (CNS). The etiology of MS is unknown, although the immune system appears to play a role.
- Trial name
- NCT00043264
- Testing
- Rifampin, Azithromycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Center for Research Resources (NCRR)
Child Development
Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso
The use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome.
- Trial name
- ARMCA (NCT03187834)
- Testing
- Azithromycin, Amoxicillin, Cotrimoxazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trichomonas Vaginitis, Chlamydia Trachomatis
Non-Invasive Sexually Transmitted Disease Testing in Women Seeking Emergency Contraception or Urine Pregnancy Testing
The purpose of this study is to determine the prevalence and treatment rates of T. vaginalis, C. trachomatis, and N. gonorrhoeae in women seeking emergency contraception or urine pregnancy testing in the Magee-Womens Hospital…
- Conditions
- Trichomonas Vaginitis, Chlamydia Trachomatis, Neisseria Gonorrhoeae Infection
- Trial name
- NCT00978848
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Trachoma
Trachoma Elimination Study by Focused Antibiotic (TESFA)
The study population consists of all households residing in eligible kebeles (sub-districts) within districts in Amhara National Regional State which are identified as having a high prevalence of trachoma and infection measured…
- Trial name
- NCT03523156
- Testing
- Azithromycin mass treatment, Azithromycin targeted treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection
Performance of Nucleic Acid Amplification Tests for the Detection of NG and CT
The purpose of this study was to use participant samples to simultaneously evaluate three nucleic acid amplification tests (NAATs) diagnostic platforms.
- Conditions
- Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection, Sexually Transmitted Infections
- Trial name
- pNAAT (NCT02870101)
- Testing
- Nucleic acid amplification test 1 for NG and CT, Nucleic acid amplification test 2 for NG and CT, Nucleic acid amplification test 3 for NG and CT
- Where
- 9 sites in United States
- Volunteers
- 2,767 people, healthy volunteers welcome
- Sponsor
- Duke University
Overactive Bladder Syndrome
Colonization of the Female Urethra With Mycoplasma Hominis, Ureaplasma Urealyticum, Chlamydia Trachomatis, or Neisseria Gonorrhea in Patients With Lower Urinary Tract Symptoms
The purpose of this study is to assess the prevalence of mycoplasma hominis, ureaplasma urealyticum, neisseria gonorrhea, and chlamydia trachomatis in women with overactive bladder symptoms, and to correlate these findings with…
- Trial name
- NCT01559623
- Testing
- retrospective data analysis
- Where
- Switzerland
- Volunteers
- 766 people
- Sponsor
- University of Zurich
Gonorrhea, Chlamydia
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
The purpose of this study is to understand if taking an antibiotic called doxycycline by mouth as soon as possible after sexual contact without a condom can reduce the risk of sexually transmitted infections (STIs), including…
- Conditions
- Gonorrhea, Chlamydia, Syphilis
- Trial name
- NCT03980223
- Testing
- Doxycycline Hyclate Delayed-Release 200 mg
- Where
- 3 sites in United States
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Urogential Chlamydia Trachomatis Infection
Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin
Evaluate the clinical efficacy and safety of WC2031 200 mg tablets taken orally once a day for 7 days versus Vibramycin (doxycycline) 100 mg capsules taken orally twice a day for 7 days, for the treatment of uncomplicated…
- Trial name
- NCT01113931
- Testing
- Doxycyline Hyclate tablet, Vibramycin (doxycyline hyclate) capsule
- Where
- 43 sites in United States
- Volunteers
- 495 people
- Sponsor
- Warner Chilcott