Clinical trials: Chlorhexidine
Gingivitis, Dental Plaque
Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices
This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners.
- Trial name
- NCT07307716
- Testing
- Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Recurrent Caries Incidence
Digital Radiography in Detection of Recurrent Caries Underneath Chlorhexidine Containing Adhesive Versus Conventional Adhesive After One Year Follow up: Randomized Clinical Trial
This study will be conducted to compare the effect of chlorexidine containing adhesive versus conventional one in prevention of secondary caries lesion underneath composite restoration over one year follow up null hypothesis
- Trial name
- NCT03139409
- Testing
- adhesive bond with chlorhexidine, Time variable
- Where
- Egypt
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Cairo University
Wound Healing
Efficacy of Hypochlorous Acid as a Postoperative Wound Antiseptic
The aim was to examine the effectiveness of hypochlorous acid on postoperative wound healing in 24 systemically healthy gingivectomy participants aged 12-30.
- Trial name
- NCT06760403
- Testing
- Hypochlorous acid
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Gingivitis
Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis
The aim of the present study is to evaluate the efficacy of 5 mouthwashes, based on different ingredients, in the treatment of generalised gingivitis.
- Trial name
- NCT04733196
- Testing
- Essential oils, Essential oils in combination with chlorhexidine 0,12%, Chlorhexidine 0,20 % in combination with aroma oils
- Where
- Bulgaria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Oral Mucosal Disorder
Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa
The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa.
- Trial name
- NCT06942026
- Testing
- Control 1
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Asepsis, Analgesia, Epidural
Chlorhexidine Versus Povidone-Iodine for Prevention of Epidural Needle Contamination in the Parturient
Infection after epidural catheter placement is fortunately rare. When it does happen, the affected person can become seriously ill.
- Conditions
- Asepsis, Analgesia, Epidural, Anesthesia, Epidural
- Trial name
- NCT00223002
- Testing
- Chlorhexidine
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Bone Densitometry
T-score Comparability Between GE Lunar Prodigy and Norland Excel Densitometers
Differences in determining bone density scores have been found when comparing different bone density machines. Reducing differences between machines will improve diagnostic agreement for patients measured at different clinics.
- Trial name
- Wildwood (NCT00593437)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
HGF, Fibroblast
Effects of Chlorhexidine on Human Gingival Fibroblasts
This prospective in vitro study aims to evaluate the effects of two chlorhexidine-based mouthwash formulations on the survival and function of human gingival fibroblasts (hGFs).
- Conditions
- HGF, Fibroblast, Chlorhexidine, Cytotoxicity
- Trial name
- NCT07669636
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Periapical Periodontitis
Evaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.
This study will evaluate the synergistic effect of CHX + H2O2 when used as an irrigant during biomechanical preparation.in root canal treatment on periapical healing and compared with Chlorhexidine( CHX) and Sodium Hypochlorite…
- Trial name
- NCT04373018
- Testing
- Sodium hypochlorite, Chlorhexidine, Chlorhexidine + Hydrogen peroxide
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Plaque Induced Gingivitis
Compare the Effect of Green Tea Mouthwash vs Chlorohexidine Mouthwash in Children With Plaque-induced Gingivitis
This study aims to assess and compare the effect of green tea mouthwash compared to chlorohexidine mouthwash in reducing gingivitis and plaque scores (in terms of plaque index and gingival index) in children with plaque-induced…
- Trial name
- NCT05803590
- Testing
- Green tea mouthwash, Chlorhexidine mouthwash
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Properties of Glass Ionomer Cements Associated With Chlorhexidine or Doxycycline
This study assessed the clinical performance of a resin-modified glass ionomer cement containing different concentrations of chlorhexidine digluconate and doxycycline hyclate.
- Trial name
- NCT02168374
- Testing
- Indirect pulp treatment
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Aline R F de Castilho
Dental Caries
Glass-ionomer Cement Containing Chlorhexidine for ART
This study evaluated the clinical and microbiological long-term effects of 1.25% CHX associated with GIC applied in primary molars using Atraumatic Restorative Treatment (ART) technique.
- Trial name
- NCT02459730
- Testing
- ART with GIC containing 1.25% CHX., ART with GIC.
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Gastroscopy
Chlorhexidine Mouthwash and Bacterial Contamination During Endoscopy
Background: Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a surgical technique that has been rapidly evolving over the last five years.
- Trial name
- NCT01154530
- Testing
- Chlorhexidine
- Where
- Denmark
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Obese, Obesity, Morbid
Treatment of Periodontitis in Obese Individuals
Obesity and gum diseases are highly prevalent in all parts of the world. Obesity can negatively influence severity and progression rates of gum diseases.
- Conditions
- Obese, Obesity, Morbid, Periodontitis
- Trial name
- CLIMBEO (NCT03103204)
- Testing
- One-stage full-mouth disinfection with chlorhexidine
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Surgical Site Infection
The Use of 2% Chlorhexidine Gluconate Impregnated Cloth Bathing in Preoperative Skin Preparation
To compare the use of towels impregnated with 2% chlorhexidine gluconate in the traditional preoperative bath with 2% chlorhexidine gluconate in preventing the occurrence of surgical site infection among patients undergoing…
- Trial name
- NCT03813693
- Testing
- towels impregnated with 2% chlorhexidine gluconate, chlorhexidine gluconate 2% liquid
- Where
- Brazil
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pneumonia, Respiratory Infection
Chlorhexidine & Pneumonia in Nursing Home Residents
The purpose of this study is determine if topical oral application of a chlorhexidine antimicrobial spray will significantly reduce pneumonia and respiratory infections, and improve oral health compared to a placebo solution in…
- Trial name
- NCT00841074
- Testing
- chlorhexidine
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Drying Time
Chlorhexidine Drying Time
Before a patient gets a spinal/epidural, their lower back is cleaned with an antiseptic solution diluted in alcohol called ChloraPrep. ChloraPrep must completely dry before starting the anesthetic procedure.
- Trial name
- Chlorhexidine (NCT02095535)
- Testing
- Chlorhexidine gluconate
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dental Plaque, Side Effects
Clinical Effects of Two New Chlorhexidine Digluconate Formulations: 0.12% and 0.03%.
In the current study we tested the hypothesis that new 0.05% Cetylpyridinium chloride (CPC) mouthrinse formulations containing 0.12% or 0.03% chlorhexidine digluconate (CHX): 1) yield similar or better clinical results regarding…
- Trial name
- NCT02194023
- Testing
- 0.12%NF, 0.03%NF, PAT
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Periapical Abscess
Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy…
- Trial name
- NCT02943759
- Testing
- Neem leaf extract, Chlorhexidine gluconate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Hygiene
An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
The aim of this study is to compare the stain effect on teeth of twice daily brushing with a 67% sodium bicarbonate containing toothpaste versus standard toothpaste (not containing sodium bicarbonate) for six weeks whilst using a…
- Trial name
- NCT01962493
- Testing
- Sodium bicarbonate/ Sodium Fluoride, Sodium fluoride, Chlorhexidine digluconate
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline