Clinical trials: Chlorhexidine
Pneumonia, Respiratory Infection
Chlorhexidine & Pneumonia in Nursing Home Residents
The purpose of this study is determine if topical oral application of a chlorhexidine antimicrobial spray will significantly reduce pneumonia and respiratory infections, and improve oral health compared to a placebo solution in…
- Trial name
- NCT00841074
- Testing
- chlorhexidine
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Dental Caries
Evaluation of Antimicrobial Efficacy of Green Tea, Garlic With Lime, Pomegranate Extract and Chlorhexidine Mouth Rinses in a Group of Egyptian Children (In-Vivo Study)
the aim of the clinical trial is to evaluate the antimicrobial efficacy of the herbal mouth rinses against chlorhexidine mouth rinse.
- Trial name
- NCT05841589
- Testing
- Green tea extract mouth rinse, Garlic with lime extract mouth rinse, Pomegranate extract mouth rinse
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- omnia sayed
Lower Extremity Surgery, Surgical Site Infection
Study on the Reapplication of Chloraprep After Lower Extremity Surgery and Prior to Dressing Application
The purpose of the current work is to determine the efficacy of the re-application of surgical prep solution in decreasing surgical site bacterial contamination following lower extremity surgery.
- Conditions
- Lower Extremity Surgery, Surgical Site Infection, Bacterial Colonization, Surgical Antiseptic
- Trial name
- NCT02017145
- Testing
- Chloraprep
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Sanford Health
Staphylococcus Aureus, MRSA Skin Infections
Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees
This cluster-randomized prospective study will evaluate the effect of hygiene-based intervention strategies on the incidence of overall SSTI and MRSA-associated SSTI among military trainees.
- Conditions
- Staphylococcus Aureus, MRSA Skin Infections, Staphylococcal Skin Infections
- Trial name
- NCT01105767
- Testing
- Chlorhexidine gluconate, Supplemental training, education and hygiene
- Where
- United States
- Volunteers
- 30,209 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction
Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in volunteers with PH in the breakdown of oral nitrate and effect on hemodynamics.
- Conditions
- Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction, Pulmonary Heart Disease and Diseases of Pulmonary Circulation
- Trial name
- NCT03787082
- Testing
- Nitrates, Chlorhexidine Gluconate Mouthwash
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Antibiotic Resistant Infection
Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients
The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.
- Trial name
- NCT01989416
- Testing
- 2% chlorhexidine wipe, Soap
- Where
- Thailand
- Volunteers
- 481 people
- Sponsor
- Mahidol University
Dental Caries, Infection, Bacterial
Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth.
The process of removing bacteria and their products from the root canals is an essential step that is achieved through the combination of mechanical preparation and irrigation with chemicals.
- Conditions
- Dental Caries, Infection, Bacterial, Tooth, Deciduous
- Trial name
- NCT05361278
- Testing
- Chlorhexidine solution, Activated chlorhexidine solution, Chlorhexidine gel
- Where
- Syria
- Volunteers
- 15 people
- Sponsor
- Damascus University
Caries
Antibacterial Effect of Chlorhexidine Added to the Preventive Protocol in Adolescent Special Needs
This study ia conducted to know the antibacterial effect of chlorhexidine on the mouth flora speciallly in adolescent special needs who can't hold the tooth brush properly
- Trial name
- NCT04679558
- Testing
- Chlorhexidine varnish added to the preventive protocol, Preventive protocol
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Halitosis
Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath
The ODOR trial will be a single-centric, double-blinded, parallel-group, double-armed pilot randomized controlled trial with a non-inferiority design.
- Trial name
- NCT06219226
- Testing
- Chlorine dioxide mouthwash, Chlorhexidine mouthwash
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Semmelweis University
Chronic Hepatitis B
3E Extension Study
The purpose of this study is to evaluate the long-term efficacy and safety of entecavir 0.5 mg/d + adefovir 10 mg/d for treatment experienced chronic hepatitis B patients.
- Trial name
- 3E Ex (NCT01834508)
- Testing
- oral entecavir 0.5mg daily and adefovir 10mg daily for 144 weeks
- Where
- 28 sites in China
- Volunteers
- 600 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Pathogenic Bacteria in the Oropharynx, Ventilator-associated Pneumonia
Chlorhexidine vs Lactobacillus Plantarum for Oral Care in Intubated ICU Patients
Critically ill patients often need ventilatory support through a plastic tube connected to a ventilator. Those patients have a altered microbiological flora in the mouth, oropharynx as well as throughout the intestine.
- Trial name
- NCT01105819
- Testing
- Lactobacillus plantarum 299 for oral care, Chlorhexidine for standard oral care
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Chronic Apical Periodontitis
Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis
The goal of this clinical study was to evaluate the effect of using different irrigation solutions in the final irrigation of root canal treatment procedures on the intensity of postoperative pain and periapical tissue healing in…
- Trial name
- NCT06834711
- Testing
- N-Acetyl Cysteine, Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Cukurova University
Surgical Site Infections, Lumbar Disc Herniation
The Effect of Number of Showers With 4% Chlorhexidine Gluconate on Prevention of Surgical Site Infections
Surgical site infections (SSIs) are the most common type of nosocomial infection in surgical departments. Although lumbar disc herniation (LDH), which is one of the common cases in neurosurgery, is a serious problem affecting…
- Trial name
- SSI (NCT06801275)
- Testing
- 1 shower with 4% chlorhexidine gluconate, 2 shower with 4% chlorhexidine gluconate
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Drain Site Complication
The Efficacy of Chlorhexidine Gluconate Gel Dressing in Preventing Surgical Drain Site Infection
This study aims to evaluate if the application of chlorhexidine gluconate dressing on surgical drain sites can decrease drain site infection vs the standard of care (dry, sterile gauze).
- Trial name
- NCT04656145
- Testing
- 3M™ Tegaderm™ CHG Chlorhexidine Gluconate I.V. Securement Dressing
- Where
- United States
- Sponsor
- NYU Langone Health
Congenital Disorders
Chlorhexidine Swabs Effectiveness in Reducing Blood Stream Infections
Children's Healthcare of Atlanta (Children's) is collaborating with Child Health Corporation of America (CHCA) in the nationwide effort to reduce catheter related blood stream infections (BSIs).
- Trial name
- NCT00485992
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Children's Healthcare of Atlanta
Periodontitis
The Efficacy and Safety of PerioChip Plus (Flurbiprofen/Chlorhexidine) Formulation in the Therapy of Adult Periodontitis
The purpose of this study is to determine the effect of the placement of a PerioChip Plus (flurbiprofen/chlorhexidine - FBP/CHX) formulation versus PerioChip (chlorhexidine) formulation versus Flurbiprofen Chip formulation versus…
- Trial name
- NCT00425451
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Dexcel Pharma Technologies Ltd.
Candidiasis, Vulvovaginal
A Clinical Trial for Chlorhexidine as Treatment for Vulvovaginal Candidiasis
The overall aim of this study is to investigate if vaginally applied 1% chlorhexidine gluconate (CHG) could be an alternative treatment to oral fluconazole (FLZ), both during an acute episode and as prophylaxis, against recurrent…
- Trial name
- NCT05059145
- Testing
- Chlorhexidine Gluconate, Fluconazole
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Oropharyngeal Gram-negative Bacilli Colonization
Microbial Epidemiology and Chlorhexidine Suscebtibily of Oropharyngeal and Intestinal Colonization
In this prospective observational study we aim to determine the prevalence of oropharyngeal and rectal Gram-negative bacilli colonization in healthy subjects, and their susceptibility to chlorehexidine.
- Trial name
- OroColi-HS (NCT02840656)
- Testing
- oropharyngeal swabbing, rectal swabbing
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Saliva
Antibacterial Effect and Substantivity of a New Chlorhexidine and Cymenol Gel on Oral Biofilm and Saliva
The objective of this project was to compare the immediate antimicrobial effect and in situ substantivity of a new 0.20% chlorhexidine (CHX) gel and cymenol with the current CHX gel formulation on dental plaque biofilm and…
- Conditions
- Healthy, Saliva, Biofilms
- Trial name
- NCT06437262
- Testing
- 0.20% CHX gel on saliva, 0.20% CHX and Cymenol gel on saliva, 0.20% CHX gel on oral biofilm
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Scarring, Skin Aging
Open-label, Prospective, Multicenter Study to Evaluate the Cutera Excel V™ Laser and a Micro-Lens Array Attachment
Open-label, Prospective, Study to Evaluate the Cutera excel V laser at 532 nm in a low fluence, high repetition rate mode and the Micro-Lens Array attachment used with excel V laser at 1064 nm and 532 nm for the improvement of…
- Trial name
- NCT03424148
- Testing
- Excel V™ Laser & Micro-Lens Array Attach
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.