Clinical trials: Cholesterol; Metabolic Disorder
Hypercholesterolemia
Effects of Ezetimibe With Simvastatin in the Therapy of Adolescents With HeFH (Study P02579)
This is a randomized, double-blind, controlled, parallel-group, multicenter, Phase-3 study to evaluate the efficacy and safety of ezetimibe with simvastatin taken alone in subjects ages 10-17 years with Heterozygous Familial…
- Trial name
- NCT00129402
- Testing
- ezetimibe with simvastatin, simvastatin
- Volunteers
- 248 people
- Sponsor
- Organon and Co
Acute Coronary Syndrome, Dyslipidemias
Low-density Lipoprotein Cholesterol Reduction With State-of-the-art Therapy in Secondary Prevention and Major Cardiovascular Adverse Events: Republic of Srpska Registry
Recent trials have demonstrated that a reduction in low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular adverse events following acute coronary syndrome (ACS).
- Trial name
- RS-ACS (NCT05081336)
- Testing
- Statin
- Where
- Bosnia and Herzegovina
- Volunteers
- 500 people
- Sponsor
- University Clinical Centre of Republic of Srpska
Dyslipidemia
A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.
The main aim of this study is to assess the effects of AZD0780 when added on top of ezetimibe or ezetimibe and rosuvastatin or ezetimibe and bempedoic acid.
- Trial name
- NCT06742853
- Testing
- AZD0780, Ezetimibe, Rosuvastatin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypercholesterolemia, Hydroxy-methylglutaryl-coenzyme A (HMG Co-A) Reductase Inhibitors Adverse Reaction
Genetically Guided Statin Therapy
The purpose of this study is to examine if using genetics can improve statin adherence in patients who should be taking statins but are not because of prior side effects.
- Trial name
- NCT01894230
- Testing
- SLCO1B1*5 allele testing, results reported at randomization, SLCO1B1*5 allele testing, results reported at end of study, Genetic testing for SLCO1B1*5 allele
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Duke University
Homozygous Familial Hypercholesterolemia (HoFH), Major Adverse Cardiovascular Events (MACE)
Evaluation of the Effect of Lomitapide Treatment on Major Adverse Cardiovascular Events (MACE) in Patients With Homozygous Familial Hypercholesterolemia
This observational, multicenter, retrospective and prospective study aims to evaluate the effect of lomitapide treatment on Major Adverse Cardiovascular Events (MACE) in patients with Homozygous Familial Hypercholesterolemia…
- Conditions
- Homozygous Familial Hypercholesterolemia (HoFH), Major Adverse Cardiovascular Events (MACE), Dyslipidemia
- Trial name
- LILITH (NCT06832371)
- Where
- 30 sites in France, Greece and 3 more
- Volunteers
- 73 people
- Sponsor
- Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)
Metabolic Syndrome
Effects of Canola Oil on Vascular and Metabolic Parameters in Individuals With Metabolic Syndrome
MetS is an early stage of CVD and is an appropriate target for dietary interventions. MetS is a clustering of risk factors (abdominal obesity, elevated serum triglycerides, low HDL-cholesterol, hypertension, elevated fasting…
- Trial name
- METCO-2013 (NCT01890330)
- Testing
- Canola Oil 25 g/d, Non-Canola Oil Mixture 25 g/d
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Familial Hypercholesterolemia
Treatment Rates and Compliance to Treatment in Patients With Familial Hypercholesterolemia
Familial hypercholesterolemia is a genetic disease characterized by increased levels of low density lipoprotein cholesterol (LDL-C).
- Trial name
- NCT04494464
- Testing
- No intervention
- Volunteers
- 367 people
- Sponsor
- Ankara Yildirim Beyazıt University
Smith-Lemli-Opitz Syndrome
Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome
The purpose of this study is to determine whether supplementation with an oil-based cholesterol suspension will correct the biochemical abnormalities in cholesterol and its precursors in individuals with the Smith-Lemli-Opitz…
- Trial name
- NCT00272844
- Testing
- crystalline cholesterol oil-based suspension
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Boston Children's Hospital
HIV Infections, Lipodystrophy
Changing to Nonprotease Inhibitor Treatment to Improve Side Effects
The purpose of this study is to learn whether changing from a type of anti-HIV drug called a protease inhibitor (PI) to another type of anti-HIV drug will help to lower the amount of fats or sugars in the blood.
- Trial name
- NCT00021463
- Testing
- Abacavir sulfate, Lamivudine and Zidovudine, Abacavir sulfate, Efavirenz
- Where
- 11 sites in United States
- Volunteers
- 342 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity (Disorder), Diabetes Type 2
Healthy Living Anson Study
The goal of this randomized delayed control intervention research study is to see if participants who receive education and healthy prepared meals improve the quality of their diet compared to participants who receive only…
- Conditions
- Obesity (Disorder), Diabetes Type 2, Heart Disease, Hypertension
- Trial name
- HLA (NCT07126587)
- Testing
- Nutrition Education and Food Delivery, Physical Activity Comparator
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Lipid Metabolism, Glucose Metabolism
Effects of Beta-glucan From Barley and Oats on Glucose and Lipid Metabolism, and Satiety
The interventional study will evaluate the effects of a regularly consumption of barley and oat flakes in crude and roasted form on the glucose and lipid metabolism as well as the postprandial saturation.
- Conditions
- Lipid Metabolism, Glucose Metabolism, Satiety
- Trial name
- gLUCAn (NCT03648112)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Jena
Dyslipoproteinemias, Hypercholesterolemia, Familial
Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry
This is a prospective German registry for patients with dyslipidemia with very high cardiovascular risk who principally meet the Gemeinsamer Bundesausschuss (G-BA) stipulations for Proprotein convertase subtilisin/kexin like type…
- Conditions
- Dyslipoproteinemias, Hypercholesterolemia, Familial, Familial Hypercholesterolemia - Homozygous, Familial Combined Hyperlipidemia
- Trial name
- PERI-DYS (NCT03110432)
- Testing
- PCSK9 Inhibitor [EPC], Standard lipid lowering therapy
- Where
- 3 sites in Germany
- Volunteers
- 1,695 people
- Sponsor
- GWT-TUD GmbH
Obesity, Wolman Disease
Breakfast for Young Women
Investigators will in a crossover study test the health effects of eating a dairy-based protein-rich breakfast, isocaloric carbohydrate-rich breakfast or no breakfast in young overweight women.
- Conditions
- Obesity, Wolman Disease, Nutrition
- Trial name
- GoDag (NCT04652713)
- Testing
- Protein-rich breakfast, Carbohydrate-rich breakfast, No breakfast
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cholesteryl Ester Storage Disease
National Lysosomal Acid Lipase Deficiency Study
Cholesteryl Ester Storage Disease (CESD) is an autosomal recessive lysosomal storage disorder (LSD) caused by mutations in the lysosomal acid lipase gene (LIPA) that markedly reduce lysosomal acid lipase (LAL) activity, leading…
- Trial name
- LAL-D (NCT02372513)
- Where
- Turkey (Türkiye)
- Volunteers
- 810 people
- Sponsor
- Ankara University
Overweight
Oxidized Omega-3 Supplements With Different Oxidation
The oxidation level of unsaturated fatty acid supplements commercialized in capsules could be a serious problem for manufacturers and a risk to consumers; health by ingesting substances whose effects are not desired.
- Trial name
- GPTPASPAD (NCT01799720)
- Testing
- Less oxidized oil and diet, More oxidized oil and diet, Hypercholesterolemic diet
- Where
- Spain
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Hypercholesterolemia
Effect of Red Yeast Rice, Phytosterols and L-tyrosol on Lipid Profile and Endothelial Function
A large body of evidence confirm the cholesterol lowering effect of red yeast rice, phytosterols and L-tyrosol. Because their mechanisms of action mime the ones of chemical statins and cholesterol absorption inhibitors, it is…
- Trial name
- NCT03065491
- Testing
- Combined nutraceutical
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Cardiovascular Diseases, Diabetes Mellitus
Retrospective Evaluation of Athens Complete Health Improvement Program (CHIP) Database
Data from participants in Athens CHIP classes from May 2011 to present will be analyzed to evaluate the differences in outcomes based on: 1) gender, 2) age, 3) whether a household member participated in the class with them.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Hypertension, Dyslipidemias
- Trial name
- NCT03025451
- Testing
- The Complete Health Improvement Program
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Ohio University
Insulin Resistance, Type 2 Diabetes
Dietary Protein and Insulin Sensitivity Study
The overall objective of the Dietary Protein and Insulin Sensitivity Study is to test the hypothesis that increased protein in a diet with reduced carbohydrate (35% energy) can ameliorate insulin resistance in the absence of…
- Conditions
- Insulin Resistance, Type 2 Diabetes, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- NCT00508937
- Testing
- Diet
- Where
- 2 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Coronary Artery Disease, Atherosclerosis
Effect of ACP-501 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Subjects With Coronary Artery Disease
This study is a phase 1, intravenous, open-label, single-dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ACP-501 (recombinant human Lecithin Cholesterol Acyl Transferase…
- Trial name
- NCT01554800
- Testing
- ACP-501
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- MedImmune LLC
Cardiovascular Diseases, Overweight and Obesity
Impact of Milk Fat Globule Membrane Supplementation on Heart and Brain Health
In a randomised, controlled cross-over manner, this trial aims to determine how short-term daily supplementation with a milk fat globule membrane-enriched ingredient impacts on cardiometabolic health and cognitive outcomes.
- Conditions
- Cardiovascular Diseases, Overweight and Obesity, Cognition
- Trial name
- NCT05939544
- Testing
- Experimental: Milk Fat Globule Membrane-enriched Powdered Ingredient
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
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