Clinical trials: Chronic Arthritis
Osteoarthritis (OA) of the Hip
PENG Block & PENG PRF
The primary aim of this study is to prospectively compare the effects of the pericapsular nerve group (PENG) block alone and the combination of PENG block with pulsed radiofrequency (PRF) on pain intensity in patients with…
- Trial name
- PENG-PRF (NCT07360093)
- Testing
- PENG Block Pulsed radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara City Hospital Bilkent
Chronic Pain, Osteoarthritis, Knee
Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis
Pain is the principal symptom in knee osteoarthritis (OA) and results in a considerable amount of years lived with disability, emotional distress and has significant socioeconomic consequences.
- Trial name
- NCT03774121
- Testing
- Cryoneurolysis, Neuromuscular exercise (GLA:D)
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Chronic Pain, Osteo Arthritis Knee
rTMS for Relieving Chronic OA Pain
In this study the investigators aim to examine the effects of Transcranial Magnetic Stimulation (TMS) on hippocampal network connectivity and pain levels in individuals with pain due to knee osteoarthritis.
- Trial name
- NCT05097729
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Sponsor
- Northwestern University
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Knee Osteoarthritis, Chronic Knee Pain
Selective Nerve Ablation for Chronic Knee Pain: A Retrospective Study
SAVE-KNEE is a single-center retrospective observational cohort study evaluating outcomes of ultrasound-guided cryoneurolysis, radiofrequency ablation and chemical neurolysis for chronic knee pain in routine clinical care.
- Trial name
- SAVE-KNEE (NCT07835672)
- Testing
- Ultrasound-Guided Cryoneurolysis, Ultrasound-Guided Radiofrequency Ablation, Ultrasound-Guided Chemical Neurolysis
- Where
- Poland
- Volunteers
- 746 people
- Sponsor
- Michał Bartoszewicz
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Knee Osteoarthritis
Effectiveness of Exercise Plus Pain Neuroscience Education on Brain Function in Knee Osteoarthritis
A three-arm randomized controlled trial will be conducted. Fifty-nine participants with KOA will be recruited in a 1:1:1 ratio. Assessor, and statistician will be blinded to group allocation.
- Trial name
- NCT06482970
- Testing
- Neuromuscular exercise plus pain neuroscience education, Neuromuscular exercise
- Volunteers
- 57 people
- Sponsor
- Universidad Santo Tomas, Chile
Osteoarthritis, Knee
Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain
This is a single center randomized controlled trial. Approximately 102 patients will be randomized to one of two treatment groups: cooled radiofrequency or conventional monopolar radiofrequency ablation.
- Trial name
- NCT02260869
- Testing
- Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Millennium Pain Center
Osteoarthritis
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint
This study will examine the effectiveness of injected hylan (Synvisc) for treating pain associated with osteoarthritis of the temporomandibular joint (jaw joint) and improving function of the joint.
- Trial name
- NCT00078351
- Testing
- High molecular weight hylan (Synvisc) injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Osteoarthritis, Knee, Knee Osteoarthritis
Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis
This study evaluates the efficacy and safety of a single IA injection of various RTX doses, Zilretta or placebo for the treatment of pain due to moderate to severe osteoarthritis knee pain..
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT04885972
- Testing
- Resiniferatoxin, Zilretta
- Where
- 6 sites in United States
- Volunteers
- 124 people
- Sponsor
- Sorrento Therapeutics, Inc.
Systemic Juvenile Idiopathic Arthritis
Study of Efficacy and Safety of Canakinumab in Japanese Patients With SJIA
This was a phase III study designed to provide efficacy and safety data for canakinumab administered for at least 48 weeks as subcutaneous (s.c.) injection every 4 weeks (q4wk) in Japanese patients with Systemic Juvenile…
- Trial name
- NCT02396212
- Testing
- Canakinumab
- Where
- 7 sites in Japan
- Volunteers
- 19 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
Acupuncture as an Adjunctive Therapy to the Pharmacological Treatment in Patients With Chronic Pain in Osteoarthritis of the Knee: a Three Armed Randomized Placebo Controlled Trial
The objective of this study is to assess the efficacy of acupuncture as an adjunctive therapy to pharmacological treatment of chronic pain due to knee osteoarthritis, as well as for, the improvement of physical functioning…
- Trial name
- NCT01398930
- Testing
- acupuncture
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- National and Kapodistrian University of Athens
Rheumatoid Arthritis, Psoriatic Arthritis
A Study in Pregnant Women With Chronic Inflammatory Diseases Treated With Cimzia (Certolizumab Pegol)
The purpose of the study is to assess systemic certolizumab pegol (CZP) exposure, the formation of anti-CZP antibodies and safety of CZP across the course of pregnancy in study participants with chronic inflammatory diseases.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Axial Spondyloarthritis
- Trial name
- CHERISH (NCT04163016)
- Testing
- Pharmacokinetics of certolizumab pegol
- Where
- 9 sites in United States, France and 4 more
- Volunteers
- 22 people
- Sponsor
- UCB Biopharma SRL
Shoulder Impingement, Shoulder Arthritis
Pragmatic Posterior Capsular Stretch Versus Sleeper Stretch in Subject With Shoulder Pathologies
The glenohumeral joint is an articulation between the glenoid of the scapula and the head of the humerus that is enclosed by a synovial capsule divided into three main components: anterior, posterior, and the axillary pouch.
- Conditions
- Shoulder Impingement, Shoulder Arthritis, Shoulder Injuries, Shoulder Capsulitis
- Trial name
- NCT05064033
- Testing
- Pragmatic Set of intervention and posterior capsular stretch, Pragmatic Set of intervention and Sleeper Stretch
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Helping Hand Institute of Rehabilitation Sciences
Knee Arthroplasty, Total, Partial Knee Arthroplasty
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Conditions
- Knee Arthroplasty, Total, Partial Knee Arthroplasty, Chronic Pain, Postoperative, Osteoarthritis (OA) of the Knee
- Trial name
- OREOS-K (NCT07895472)
- Testing
- Standard care, Multicomponent opioid reduction and pain management pathway
- Volunteers
- 170 people
- Sponsor
- McMaster University
Knee Osteoarthritis, Knee Pain Chronic
Effects of Internet / Web-based Exercises on the Population With Knee Arthritis
1. To test whether internet-based exercises reduce the pain in knee OA 2. To check whether internet-based exercises improve the physical activity in the patients with knee OA. 3.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Sleep Disturbance
- Trial name
- Knee OA (NCT03545048)
- Testing
- Internet based exercises
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Nottingham
Chronic Pain
Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Background and significance: Treatment with opioid pain medications (like hydrocodone and morphine) is common for severe pain, but studies show these medications may not always help and can cause serious problems.
- Trial name
- VOICE (NCT03026790)
- Testing
- Medication management, Non-pharmacological pain management, Buprenorphine-Naloxone
- Where
- United States
- Volunteers
- 820 people
- Sponsor
- University of Minnesota
Transcutaneous, Pulsed Radiofrequency
Transcutaneous Pulsed Radiofrequency Application Plus Genicular Nerve Block Versus Intraarticular Hyaluronic Acid Injection for Management of Chronic Pain in Knee Osteoarthritis.
The aim of the present study is to compare the analgesic efficacy of combined transcutaneous pulsed radiofrequency plus genicular nerve block with bupivacaine plus corticosteroid versus intraarticular Hyaluronic acid injections…
- Conditions
- Transcutaneous, Pulsed Radiofrequency, Genicular Nerve Block, Intraarticular
- Trial name
- NCT06710782
- Testing
- Hyaluronic acid, Transcutaneous pulsed radiofrequency
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Rheumatoid Arthritis, Atherosclerotic Ischemic Disease
Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study
The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that…
- Conditions
- Rheumatoid Arthritis, Atherosclerotic Ischemic Disease, Pulmonary Disease, Depressive Disorder
- Trial name
- COTIRA (NCT07363980)
- Where
- 4 sites in Denmark
- Volunteers
- 4,000 people
- Sponsor
- Ellen Margrethe Hauge