Clinical trials: Chronic Cluster Headache
Cluster Headache
A Study to Explore the Long-Term Safety and Efficacy of Fremanezumab (TEV-48125) for the Prevention of Cluster Headache
This is a 68-week study to evaluate the long-term safety and efficacy of fremanezumab in participants with cluster headache (CH).
- Trial name
- ENFORCE (NCT03107052)
- Testing
- Fremanezumab
- Where
- 83 sites in United States, Australia and 10 more
- Volunteers
- 275 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Episodic Cluster Headache
Civamide Nasal Solution for Cluster Headache
The purpose of this study is to evaluate the safety and efficacy of intranasally administered civamide nasal solution in the prevention of cluster headaches during an episodic cluster headache period.
- Trial name
- ECH (NCT01341548)
- Testing
- Civamide nasal solution 0.01%
- Volunteers
- 180 people
- Sponsor
- Winston Laboratories
Chronic Cluster Headache
Pathway CH-1 Long-Term Follow-Up
The objective of the study is to demonstrate the long-term safety and performance of the ATI Neurostimulation System when used for stimulation of the sphenopalatine ganglion (SPG) in cluster headache subjects.
- Trial name
- NCT01616511
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 33 people
- Sponsor
- Autonomic Technologies, Inc.
Cluster Headache
Pathway CH S&E Registry
Monitor the safety and performance of the Pulsante Microstimulator System.
- Trial name
- SER (NCT02440776)
- Where
- 9 sites in Denmark, Germany and 3 more
- Volunteers
- 30 people
- Sponsor
- Autonomic Technologies, Inc.
Chronic Cluster Headache
A 1-year Trial to Inform About Long-term Exposure to Eptinezumab in Participants With Chronic Cluster Headache (cCH)
The main goal of this trial is to inform about long-term safety and tolerability of eptinezumab in participants with chronic cluster headache.
- Trial name
- CHRONICLE (NCT05064397)
- Testing
- Eptinezumab
- Where
- 31 sites in United States, Denmark and 7 more
- Volunteers
- 131 people
- Sponsor
- H. Lundbeck A/S
Primary Headaches (Migraines, Tension, Cluster Headaches)
Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study
Chronic headaches are associated with changes in brain structure and function that may be associated with increased suffering and disability.
- Trial name
- NCT06841627
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Cluster Headache
Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache
The purpose of this study is to test the effects of sodium oxybate on headache response (frequency), sleep quality and quality of life in the prophylactic treatment of patients with chronic and episodic cluster headache.
- Trial name
- SOinCH (NCT02637648)
- Testing
- Sodium Oxybate
- Volunteers
- 60 people
- Sponsor
- Ramin Khatami
Chronic Cluster Headache
Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacks
The goal of this clinical trial is to evaluate the efficacy of low sodium oxybate (LXB) (brand name Xywav) in the treatment of (nocturnal) cluster headache attacks in subjects with chronic cluster headache.
- Trial name
- SUNCET (NCT06950281)
- Testing
- Low Sodium Oxybate
- Volunteers
- 52 people
- Sponsor
- Leiden University Medical Center
Cluster Headache
PACAP-38 Infusion in Patients With Cluster Headache
A randomized, double-blinded, two-way crossover study investigating the headache inducing capabilities of PACAP-38 in patients with cluster headache.
- Trial name
- NCT03814226
- Testing
- Evaluation of headache inducing capabilities of PACAP38
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Danish Headache Center
Cluster Headache
Psilocybin for the Treatment of Cluster Headache
The purpose of this study is to investigate the effects of an oral psilocybin pulse regimen in cluster headache. Subjects will be randomized to receive oral placebo, low dose psilocybin, or high dose psilocybin in three…
- Trial name
- NCT02981173
- Testing
- 0.143 mg/kg Psilocybin or 10 mg Psilocybin, 0.0143 mg/kg Psilocybin or 1 mg Psilocybin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Cluster Headache
Sleep, Circadian Rhythms and Cluster Headache
The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache.
- Trial name
- NCT01447641
- Testing
- Polysomnography, Actigraphy
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Surrey
Cluster Headache
Prophylactic Effects of Psilocybin on Chronic Cluster Headache
The purpose of this study is to investigate the prophylactic effects of psilocybin in chronic cluster headache. Subjects will receive a low dose of psilocybin during 3 sessions spaced by one week.
- Trial name
- EPOCH (NCT04280055)
- Testing
- Psilocybin
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Gitte Moos Knudsen
Cluster Headache
Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout
Sleep study in episodic cluster headache patients.
- Trial name
- NCT03439722
- Testing
- Polysomnography
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Danish Headache Center
Migraine, Cluster Headache
Pain Biomarker Study
This study investigates molecular and physical biomarkers of headaches in order to better understand mechanisms of these diseases. There are 3 main parts: 1.
- Conditions
- Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua
- Trial name
- PBS (NCT03511846)
- Testing
- Oral capsaicin, Topical capsaicin, Intranasal capsaicin
- Where
- United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cluster Headache
A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache
Cluster headache is a disorder marked by frequent attacks of short-lasting, severe, unilateral head pain with associated autonomic symptoms. It is the most severe head pain syndrome known.
- Trial name
- NCT01298921
- Testing
- Oxygen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Geisinger Clinic
Chronic Cluster Headache
A Study Comparing the Efficacy and Safety of Fremanezumab (TEV-48125) for the Prevention of Chronic Cluster Headache (CCH)
The purpose of the current study is to evaluate the efficacy and safety of Fremanezumab (TEV-48125), in the prevention of CCH in adult participants.
- Trial name
- NCT02964338
- Testing
- Fremanezumab
- Where
- 83 sites in United States, Australia and 10 more
- Volunteers
- 259 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Primary Headache Disorders
A Prospective Observational Registry of Primary Headache Patients Treated With Ausanil
This study is an observational study with the primary objective to assess the safety and tolerability of Ausanil in the treatment of primary headache disorders.
- Trial name
- NCT02392273
- Testing
- Ausanil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VR1 Corporation
Primary Headache
Two US-guided Techniques for Greater Occipital Nerve Blocks
Headache is one of the most common reasons for patients to access healthcare. Greater occipital nerve (GON) block with local anesthetic and steroid has been described for the management of primary headache refractory to…
- Trial name
- GON (NCT02031822)
- Testing
- US-guided Greater Occipital Nerve Injection
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cluster Headache, Headache Disorders
Resting State Functional Connectivity in Cluster Headache
Cluster headache is a highly disabling primary headache disorder, characterized by severe, excruciating, recurrent unilateral headache attacks.
- Trial name
- NCT06206772
- Testing
- Resting state HD-EEG recording
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cluster Headache, Obesity
DBS of the Third Ventricle for Cluster Headache and Obesity
Study of Deep Brain Stimulation of the Third ventricle in Cluster Headache and Obesity treatment.
- Trial name
- DBS V3 (NCT02782533)
- Testing
- Deep Brain Stimulation V3
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Grenoble