Clinical trials: Chronic Coronary Disease
Chronic Heart Failure, Hypertension
Nebivolol Versus Carvedilol in Patients With Heart Failure
BACKGROUND Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (CHF)…
- Trial name
- NCT00511888
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS San Raffaele
Hypertension, Coronary Disease
Analyzing How Genetics May Affect Response to High Blood Pressure Medications
High blood pressure is one of the most common health problems in the United States. There are many medications to treat high blood pressure, but there is a large variance in how people respond to these medications.
- Conditions
- Hypertension, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00563901
- Where
- 2 sites in United States
- Volunteers
- 37,939 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
STEMI, NSTEMI
Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk…
- Conditions
- STEMI, NSTEMI, Chronic Coranary Sindrome, Unstable Angina (UA)
- Trial name
- Predict AI (NCT07866144)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Heart Failure
The Effect of a Five Week Electrical Myostimulation Program in Chronic Diseases
Patients afflicted with Chronic Heart Failure (HF) typically do not maintain stable cardiac function for the remainder of their life and consequently require continuous medical management and intermittent hospital admissions.
- Trial name
- NCT01695421
- Testing
- Medium-frequency alternating current, Burst-modulated alternating current, Functional electrical stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Brasilia
Chronic Heart Failure
Readmission Risk of Patients With Heart Failure.
Heart failure (HF) is a frequent, serious, and costly chronic disease: it leads to 150,000 hospitalizations each year in France at a cost of 525 million Euros.
- Trial name
- PREDIC (NCT04984928)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Montpellier
Chronic Total Occlusion of Coronary Artery, Angina Pectoris
Observational Registry on Clinical Outcome After Diagnosis of Chronic Total Occlusions
This registry aims at enrolling all consecutive patients presenting with at least one chronic total occlusion at coronary angiogram as diagnosed during angiography in our catheterization laboratory during 1 year.
- Trial name
- PETS-CTO (NCT04145167)
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Ziekenhuis Netwerk Antwerpen (ZNA)
Heart Failure, Left Bundle-Branch Block
Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure
The purpose of this study is to evaluate the efficacy and safety of conduction system pacing versus biventricular pacing in patients with chronic heart failure with reduced ejection fraction and left bundle branch block.
- Conditions
- Heart Failure, Left Bundle-Branch Block, Cardiac Resynchronization, Conduction System Pacing
- Trial name
- PhysioSync-HF (NCT05572736)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- 14 sites in Brazil
- Volunteers
- 179 people
- Sponsor
- Hospital Moinhos de Vento
Long COVID, Post-COVID Conditions
Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue
Long COVID can cause persistent symptoms such as fatigue, cognitive difficulties commonly described as brain fog, reduced exercise tolerance, and impaired quality of life.
- Conditions
- Long COVID, Post-COVID Conditions, Fatigue, Cognitive Dysfunction
- Trial name
- NEUROSTIM-LC (NCT07709234)
- Testing
- Transcranial Direct Current Stimulation
- Volunteers
- 20 people
- Sponsor
- University of Las Palmas de Gran Canaria
Stable Chronic Angina, Ischemic Heart Disease
Effect of Remote Intervention in Patients With SCAD
The study was a multicenter, two-arm, parallel, open-label, prospective clinical trial that evaluated a remote intervention with 1 year of follow-up.
- Conditions
- Stable Chronic Angina, Ischemic Heart Disease, Coronary Artery Disease, Heart Diseases
- Trial name
- NCT04795492
- Testing
- remote intervention, Routine outpatient follow-up
- Where
- China
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure, Congestive
Prednisone for Decompensated Congestive Heart Failure
We designed this, randomized, double-blind, placebo-controlled trial to determine the clinical efficacy of chronic administration of prednisone on renal function and clinical status when added to standard care.
- Trial name
- NCT00369044
- Testing
- prednisone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hebei Medical University
Chronic Coronary Syndrome, Hypertension
Benidipine in Hypertensive and/or Chronic Coronary Syndrome Patients
Evaluation of the clinical outcomes of Benidipine initiated by physician's preference in patients with hypertension and/or angina pectoris (chronic coronary syndrome) presenting to cardiology outpatient clinics in Türkiye.
- Conditions
- Chronic Coronary Syndrome, Hypertension, Angina Pectoris
- Trial name
- BenidipineTR (NCT06808321)
- Testing
- Benidipine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 1,659 people
- Sponsor
- The Society of Prevention and Awareness of Cardiovascular Diseases
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
This will be a double blind, randomised, placebo controlled, single and multiple oral dose study conducted in 3 parts: Part A, Part B and Part C.
- Conditions
- Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies, MELAS Syndrome, Mitochondrial Myopathies
- Trial name
- NCT03888716
- Testing
- KL1333
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abliva AB
Hyperlipidemia, Hypercholesterolemia
Patient and Provider Assessment of Lipid Management Registry
The purpose of the Patient and Provider Assessment of Lipid Management Registry (PALM) is to gain a better understanding of physicians' cholesterol medication prescribing practices, patient and physician attitudes and beliefs…
- Conditions
- Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, Diabetes
- Trial name
- PALM (NCT02341664)
- Where
- 14 sites in United States
- Volunteers
- 7,658 people
- Sponsor
- Duke University
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Heart Failure
Portable Oxygen Concentrator in Non-hospitalized Patients With Chronic Heart Failure
This is a one-day, proof-of-concept, pilot study of portable oxygen concentrator (POC) administration and Six Minute Walk Test (6MWT) distance in patients with stable chronic heart failure.
- Trial name
- NCT05719363
- Testing
- Inogen Rove 6 Portable Oxygen Concentrator
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Inogen Inc.
Hyperalgesia, Pain
Local Anesthetic Infusion and Sternotomy
Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy.
- Trial name
- CARDIODOLAL (NCT00802048)
- Testing
- Local anesthetic (Ropivacaine), Saline
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Pulmonary Disease, Chronic Obstructive
RELOVAIR® Lung Deflation Study
The primary objective of the study is to test the hypothesis that lung hyperinflation contributes to cardiac dysfunction in COPD and that the treatment of lung deflation with FF/VI Inhalation Powder 100/25 mcg administered once…
- Trial name
- NCT01691885
- Testing
- Fluticasone Furoate, Vilanterol
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
A Study on the Heat Transport Characteristics of Meridian Phenomenon for the Heart and Lung Meridians Based on Patients With Stable Angina Pectoris
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches.
- Trial name
- NCT04046640
- Testing
- Infrared thermal imaging
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Chinese Medical University
Cardiovascular Disease, Chronic Obstructive Pulmonary Disease
Safety of the CO-rebreathing Method in Stable Coronary Artery Disease and COPD Patients
The primary objective is to establish the safety of the CO-rebreathing method for measuring total blood and plasma volume in CAD patients.
- Trial name
- NCT01470274
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- Norwegian University of Science and Technology
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