Clinical trials: Chronic Cough
Asthma, Cough
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal…
- Conditions
- Asthma, Cough, Cough Variant Asthma
- Trial name
- NCT03105843
- Testing
- Methacholine (MCh) Challenge Testing, Eucapneic Voluntary Hyperventilation (EVH), Mannitol Inhalation Kit
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dr. Diane Lougheed
Chronic Cough
A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)-China Extension
The primary objective of this study will be to evaluate the efficacy of gefapixant (MK-7264) in reducing cough frequency as measured over a 24-hour period.
- Trial name
- NCT04525885
- Testing
- Gefapixant 45 mg twice daily (BID), Gefapixant 15 mg BID, Gefapixant 45 mg BID
- Where
- 8 sites in China
- Volunteers
- 161 people
- Sponsor
- Merck Sharp & Dohme LLC
COPD
Human Safety of Capsaicin Inhalation Challenge Testing for Young and Older Men
In 2004, the investigators initiated a human Capsaicin inhalation experiment under an Investigational New Drug (IND) protocol approved by the FDA (IND 69,642) and the subject safety procedures instituted and approved by the…
- Trial name
- Capsaicin (NCT01621685)
- Testing
- biological/vaccine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Chronic Obstructive Pulmonary Disease, Acute Exacerbation Copd
COPD Exacerbation Blood and Urine Biomarkers Study
This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation Copd, Alpha-1 Anti-trypsin Deficiency
- Trial name
- NCT03823443
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Asthma
A Case-control Study on the Differentiation Between Cough Variant Asthma and Chronic Cough
this study aimed to compare characters in pulmonary function of patients with cough variant asthma and chronic cough and establish a diagnostic model.
- Trial name
- NCT06199830
- Testing
- positive bronchial provocation test
- Where
- China
- Volunteers
- 645 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis
Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
The purpose of this study is to determine whether lozenges containing interferon-alpha can reduce the frequency and severity of coughing in patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Cough
- Trial name
- NCT00690885
- Testing
- interferon-alpha lozenges
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
Lung Diseases, Interstitial
INREAL - Nintedanib for Changes in Dyspnea and Cough in Patients Suffering From Chronic Fibrosing Interstitial Lung Disease (ILD) With a Progressive Phenotype in Everyday Clinical Practice: a Real-world Evaluation
The primary objective of this observational study is to investigate the correlation between changes from baseline at 52 weeks in forced vital capacity (FVC) and changes from baseline at 52 weeks in dyspnea score points or cough…
- Trial name
- INREAL (NCT04702893)
- Testing
- Nintedanib
- Where
- 21 sites in Germany
- Volunteers
- 108 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Comparative Effects of Costophrenic Assisted Cough and Anterior Chest Compression Technique in COPD Patients
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production and wheezing.
- Trial name
- NCT05922241
- Testing
- Costophrenic assisted cough, Anterior chest compression
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Cough (CC)
Wenjuanxing-Based Multidimensional Etiologic Screening and Clinical Validation of Chronic Cough in Children
Chronic cough is a common and burdensome condition in children, with complex and overlapping etiologies that often lead to delayed diagnosis, misdiagnosis, and inappropriate treatment.
- Trial name
- NCT07306637
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Children's Medical Center
Chronic Cough
Analysis of the Reliability and Validity of the Chinese Version of CC-QoL
At present, there is no research scale designed for the quality of life of children with chronic cough in China, most of them use the cough scale designed for adults to evaluate the quality of life of children.
- Trial name
- NCT05362097
- Testing
- The reliability and validity of the Chinese version of CC-QoL
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Refractory Chronic Cough
The Effect of Nalbuphine Extended-Release (NAL ER) on Cough in Participants With Refractory Chronic Cough (RCC)
The purpose of this study is to evaluate the efficacy and safety of Nalbuphine ER Extended-release tablets for the treatment of participants with RCC.
- Trial name
- LAKE (NCT07671924)
- Testing
- NAL ER
- Where
- 10 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Trevi Therapeutics
Cough
Stimulation of the Larynx to Treat Unexplained Chronic Cough
Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.
- Trial name
- NCT05273190
- Testing
- Vibrotactile Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Chronic Cough, Type 2 Diabetes
Chronic Cough and Small Fiber Neuropathy
Diabetic patients with and without chronic cough will be included in this study. After giving their informed consent, the patients will perform a spirometry, chest X-ray at the inclusion visit.
- Trial name
- CHROCOS (NCT03787511)
- Testing
- Cough assessment, Neurological tests and cardiovascular tests, Skin biopsy
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Toulouse
Pertussis, Chronic Cough
A Multi-center Study to Determine the Prevalence and Influence of Pertussis on Subacute Cough in Shenzhen
A prospective, multi-center, observational clinical trail. Aim to evaluate the real incidence of COPD pertussis and the impact of pertussis on subaute cough.
- Trial name
- NCT04694963
- Testing
- Blood sample, Data collection, Throat swab
- Where
- 26 sites in China
- Volunteers
- 500 people
- Sponsor
- Shenzhen People's Hospital
Chronic Cough
Single-center Clinical Study on the Safety and Effect of Bronchoscopic Cryotherapy in Patients With Chronic Cough
Chronic cough is one of the most common complaints in respiratory specialty clinics, imposing significant economic burden on patients and severely affecting their quality of life.
- Trial name
- ColdCough (NCT06378671)
- Testing
- General treatment, Cryotherapy Treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou Medical University
Cough
Influence on Cough and Airway Symptoms by Oral Capsaicin
Study objectives To establish whether an oral intake of Capsicum oleoresin; capsaicinoids expressed as 0.4 mg capsaicin (C18H27N03; Mw: 305.4) in each capsule (from chili extract) can desensitise the cough reflex and improve…
- Trial name
- NCT04125563
- Testing
- Capsicum Oleoresin
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Vastra Gotaland Region
Refractory Chronic Cough
A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)
A randomized, double-blind, placebo-controlled, crossover, dose escalation study to assess the efficacy and tolerability of gefapixant (AF-219; MK-7264) in participants with refractory chronic cough.
- Trial name
- NCT02349425
- Testing
- Gefapixant
- Volunteers
- 59 people
- Sponsor
- Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Chronic Cough
An Open Label Trial of Azithromycin in Chronic Productive Cough
We have noticed a group of patients presenting with a longstanding wet cough which has often been treated as asthma. The cough is productive of sputum which frequently contains bacteria, but does not resolve with standard…
- Trial name
- AZCC (NCT02196493)
- Testing
- Azithromycin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Chronic Refractory Cough
A Comprehensive Evaluation of the Impact of ATP on Laryngeal Symptoms, Hypersensitivity and Function
OBJECTIVES To deliver a comprehensive model of laryngeal assessment, evaluating both the sensory and motor components of upper airway control and to relate this to symptom disturbance.
- Trial name
- MISP COUGH (NCT05570981)
- Testing
- Laryngeal sensitivity testing
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Chronic Cough
Cough Count Validation
People with respiratory infection, asthmatic patients and cystic fibrosis (CF) patients suffer from a multitude of pathologies of airways and are often inflicted with chronic cough.
- Trial name
- NCT01413698
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- KarmelSonix Ltd.