Clinical trials: Chronic Disease of Cardiovascular System
Heart Failure, Cardio-renal-metabolic Syndrome
CArdio-Reno- Hepato -MEtabolic Disease iN Chronic Heart Failure (CARMEN-CHF)
Study aims to investigate the incidence, associations and prognostic value of CRGM and its components: chronic kidney disease, type 2 diabetes, atherosclerotic cardiovascular diseases, and non-alcoholic fatty liver disease in…
- Trial name
- CARMEN-CHF (NCT07380828)
- Volunteers
- 3,000 people
- Sponsor
- Russian Scientific Medical Society of Therapists
Coronary Artery Disease
ESCALATion of Medical Therapy Following Multimodality Plaque Evaluation in High-risk Chronic Coronary Syndromes
ESCALATE will provide a thorough investigation of how anti-inflammatory therapy, with low-dose colchicine, affects patients with stable coronary artery disease.
- Trial name
- ESCALATE (NCT06469528)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Hypertension, Chronic Heart Failure
Tolerability, Pharmacokinetics and Pharmacodynamics of Six Multiple Rising Dose Regimens of BIA 5-453
The purpose of this study is to assess the tolerability of BIA 5-453 after six multiple rising dose regimens of BIA 5-453.
- Trial name
- NCT02840565
- Testing
- BIA 5-453
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Chronic Venous Insufficiency
The Effect of Structured Exercise on Chronic Venous Insufficiency
Individuals with Chronic Venous Insufficiency (CVI) face a number of complications, such as, muscular dysfunction, limited ankle range of motion(ROM) and diminished calf muscle pump function.
- Trial name
- CVI (NCT03562546)
- Testing
- Strength From Within
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- Shannon Hernon
End Stage Renal Disease
Mid-HDF Randomized Controlled Study on Outcome
The purpose of this study is to determine whether mid-dilution hemodiafiltration is effective in the reduction of the crude mortality risk in patients who have been undergoing renal replacement treatment for less than 1 year.
- Trial name
- MILESTONE (NCT01693354)
- Testing
- Mid-dilution HDF, HF dialysis
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 500 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Ischemic Stroke, Chronic Stroke
Investigation of Neural Stem Cells in Ischemic Stroke
A study of stereotactic, intracerebral injection of CTX0E03 neural stem cells into patients with moderate to moderately severe disability as a result of an ischemic stroke.
- Conditions
- Ischemic Stroke, Chronic Stroke, Hemiparesis, Arm Paralysis
- Trial name
- PISCES III (NCT03629275)
- Testing
- CTX0E03 Drug Product and delivery device
- Where
- 23 sites in United States
- Volunteers
- 15 people
- Sponsor
- ReNeuron Limited
Coronary Artery Disease
Effect of Grape Seed Extract Plus Ascorbic Acid on Endothelial Function
A pilot study of 15 subjects will be conducted to confirm an acute effect of grape seed extract on endothelial function. We then will perform a a randomized, double blind, placebo controlled crossover study designed to…
- Trial name
- NCT00554242
- Testing
- Grape seed extract and ascorbic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Uremia, Chronic Renal Failure
Uremic Hyperhomocysteinemia -A Folate Trial for Possible Prevention of Cardiovascular Events
Homocysteine recently gained access to the category of risk factor for the development of atherosclerotic cardiovascular disease in the general population.
- Conditions
- Uremia, Chronic Renal Failure, Hemodialysis, Hyperhomocysteinemia
- Trial name
- NCT00317005
- Testing
- folate treatment
- Where
- 2 sites in Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Estadual de Londrina
Chronic Limb-Threatening Ischemia
The Role of Glass Stage Compared to WIFI Stage in Predicting Limb Salvage
compare between GLASS and WIFI Staging in predicting limb salvage in patients with chronic limb threatening ischemia ( CLTI) undergoing endovascular revascularization.
- Trial name
- NCT06209866
- Testing
- PTA
- Volunteers
- 28 people
- Sponsor
- Assiut University
Leg Ulcer
Evaluation of a Ionic Silver and Honey Preparation to Treat Chronic Wounds of the Lower Legs
In this open study, the primary objective is to study the efficacy and clinical outcome of the chronic wounds treated with this preparation for 8 weeks on 30 adults.
- Trial name
- NCT01111695
- Testing
- ApisSept
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy
Study of Default Options in Advance Directives
Default options represent the events or conditions that are set into place if no alternatives are actively chosen. The setting of default options has well-established effects on a broad range of human decisions, but its influence…
- Conditions
- COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy, Idiopathic Pulmonary Fibrosis, Other Interstitial Lung Disease Without Curative Therapy
- Trial name
- NCT01817686
- Testing
- Comfort Default AD forms, Life Extension Default AD forms, Standard Default AD forms
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Chronic Disease, Cardiovascular Disease
Synchronization to Improve Non-Adherence to Cardiovascular Medications
The aim of this study is to evaluate if synchronizing when patients with diabetes and/or coronary artery disease fill their prescriptions improves long-term adherence to these medications.
- Conditions
- Chronic Disease, Cardiovascular Disease, Diabetes Mellitus
- Trial name
- SyNCMed (NCT01963156)
- Testing
- Prescription synchronization
- Where
- United States
- Volunteers
- 3,675 people
- Sponsor
- Brigham and Women's Hospital
Venous Leg Ulcer, Bacterial Infections
Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular Ulcers
This study will determine the effectiveness of CUTIMED® hydrophobic dressings against AQUACEL® silver dressings in bacterial colonization of vascular ulcers.
- Conditions
- Venous Leg Ulcer, Bacterial Infections, Chronic Ulcer of Skin of Lower Limb Nos
- Trial name
- CUCO-UV (NCT03667937)
- Testing
- CUTIMED, AQUACEL silver
- Where
- Spain
- Volunteers
- 204 people
- Sponsor
- University of Malaga
Neuropathic Diabetic Ulcer - Foot
Safety Trial of the RedDress Wound Care System (RD1) in Management of Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
The purpose of this study is to assess the safety of the RedDress Wound Care System (RD1) in patients Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
- Trial name
- NCT01396837
- Testing
- RedDress Wound Care System (RD1)
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- RedDress Ltd.
Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia
Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies
To see if it is possible to use short-duration tacrolimus after a peripheral blood stem cell transplant in certain malignancies that are considered difficult to engraft.
- Conditions
- Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia
- Trial name
- NCT02556931
- Testing
- Fludarabine, Cyclophosphamide, Total body irradiation
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Heart Failure
Safety and Efficacy of Autologous Cardiopoietic Cells for Treatment of Ischemic Heart Failure.
Evaluation the safety and efficacy of C3BS-CQR-1 by comparing the overall response to standard of care and C3BS-CQR-1 relative to standard of care and a sham procedure.
- Trial name
- CHART-1 (NCT01768702)
- Testing
- Injection of C3BS-CQR-1
- Where
- 35 sites in Belgium, Bulgaria and 7 more
- Volunteers
- 315 people
- Sponsor
- Celyad Oncology SA
Hypertension, Chronic Heart Failure
Tolerability, Pharmacokinetics and Dopamine ß-hydroxylase (DßH) Inhibition Profile of BIA 5-453
The purpose of this study is to assess the safety and tolerability of BIA 5-453 after single oral doses
- Trial name
- NCT02845037
- Testing
- BIA 5-453
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Congestive Heart Failure, Chronic Heart Failure
Significance of Impedance Cardiography and Early Repolarization Pattern in ECG in Congestive Heart Failure
Congestive heart failure (CHF) is a disorder of the heart when structural or functional heart disease impairs the heart's ability to work properly.
- Conditions
- Congestive Heart Failure, Chronic Heart Failure, Right Ventricular Failure, Heart Failure
- Trial name
- SICERE-CHF (NCT05480345)
- Testing
- Impedance cardiography
- Where
- Lithuania
- Volunteers
- 301 people
- Sponsor
- Lithuanian University of Health Sciences
Chronic Kidney Disease
The Canadian Prevention of Renal and Cardiovascular Endpoints Trial
Advanced kidney disease with it's associated heart and blood vessel problems are becoming more frequent. These problems markedly affect length and quality of life and cost a lot to treat.
- Trial name
- CanPrevent (NCT00231803)
- Testing
- Combined CKD and CVD Prevention, Cardiovascular Disease prevention, Treatment of Chronic Kidney Disease complications
- Where
- 5 sites in Canada
- Volunteers
- 474 people
- Sponsor
- Brendan Barrett
Blood Coagulation
Anticoagulation in Chronic Hemodialysis Patients Versus Hemodialyzer Fiber Patency, Bleedings and Quality of Life
Stable chronic hemodialysis patients are included in this observational study. After a midweek dialysis (test moment 1), the hemodialyzer is dried and scanned in a micro Computed Tomography scanner to quantify the number of…
- Trial name
- ClotSigns (NCT05365542)
- Testing
- Hemodialyzer scanning, Bleeding Questionnaires, Quality of life questionnaire
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
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