Clinical trials: Chronic Diseases in Adolescence
Hidradenitis Suppurativa
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)
The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) Dose A and Dose B compared to placebo in participants with moderate to severe hidradenitis suppurativa (HS).
- Trial name
- NCT06799000
- Testing
- Remibrutinib Dose A, Remibrutinib Dose B
- Where
- 139 sites in United States, Argentina and 18 more
- Volunteers
- 588 people
- Sponsor
- Novartis Pharmaceuticals
Cerebral Palsy
Home-Based Training With Feedback to Improve Outcomes in Adolescents and Young Adults With Cerebral Palsy..
This clinical trial aims to determine whether extrinsic feedback through music enhances the effects of home-based motor training for adolescents and young adults with cerebral palsy (CP) and whether feedback improves adherence to…
- Trial name
- THRIVE-CP (NCT06962618)
- Testing
- Music Motion Group, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Copenhagen
Chronic Hepatitis B
Safety and Efficacy of Adefovir Dipivoxil in Children and Adolescents With Chronic Hepatitis B
The purpose of this study is to investigate the efficacy and safety of adefovir dipivoxil for the treatment of chronic hepatitis B in children and adolescents (age 2 to less than 18 years) following 48 weeks of…
- Trial name
- NCT00095121
- Testing
- Adefovir Dipivoxil (ADV), Lamivudine
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- Gilead Sciences
Cerebral Palsy Infantile
Study of Sagittal Pelvic Statics in the Sitting Position in Children With Cerebral Palsy
Cerebral palsy is the leading cause of motor disability in children. Children with little or no walking (GMFCS III, IV and V) represent 43% of children with cerebral palsy, the majority of whom present pelvic and spinal…
- Trial name
- SPS-PC (NCT05657548)
- Testing
- spine and pelvis radiography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cerebral Palsy
Relaxation Training to Decrease Pain and Improve Function in Adolescents With Cerebral Palsy
This study will examine the effectiveness of relaxation training for providing pain relief and improving physical and psychological functioning in youth with physical disabilities due to cerebral palsy.
- Trial name
- NCT00061230
- Testing
- biofeedback-monitored relaxation training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Fatigue Syndrome, Chronic, Epstein-Barr Virus Infection
Mental Training for CFS Following EBV Infection in Adolescents
The general aim of this study is to investigate the effect of an individually tailored mental training program in adolescents developing chronic fatigue syndrome (CFS) after an acute Epstein Barr-virus (EBV) infection.
- Trial name
- NCT02499302
- Testing
- Mental training
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial
The purpose of this study IS to explore the underlying pathophysiology of chronic fatigue syndrome (CFS) in adolescents, particularly focusing on genetics, infections/immunology, endocrinology, autonomic control and cognitions to…
- Trial name
- NorCAPITAL (NCT01040429)
- Testing
- Clonidine, Lactose capsula
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Health-Related Quality-of-Life, Adolescent
HEALTH-RELATED QUALITY OF LIFE IN CEREBRAL PALSY: AGREEMENT BETWEEN ADOLESCENTS, CAREGIVERS AND PHYSIOTHERAPISTS
Health-related quality of life (HRQoL) has recently become a widely used outcome measure. Although self-reporting is considered the gold standard, proxy reports are commonly used for adolescents with cerebral palsy (CP).
- Conditions
- Health-Related Quality-of-Life, Adolescent, Cerebral Palsy (CP)
- Trial name
- NCT07211594
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Hacettepe University
Chronic Pain, Musculoskeletal Pain
Targeted Realtime Assessment of Chronic Pain in Youth
The purpose of this study is to evaluate the feasibility and acceptability of using wearable digital health technology for continuous monitoring of physiological, sleep, and physical activity data in adolescents with chronic…
- Trial name
- TRAC-Pain (NCT06867757)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Stanford University
Pain, Postoperative, Pain
Improved Rehabilitation After Spinal Surgery in Adolescents
Impact of the OFA technique on postoperative recovery from adolescent spine surgery and the incidence of chronic postoperative pain.
- Conditions
- Pain, Postoperative, Pain, Scoliosis, Spinal Fusion
- Trial name
- NCT04183049
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Autism Spectrum Disorder, Developmental Disability
Propranolol for Challenging Behaviors in Autism
Severe challenging behaviors such as aggression and self-injury can cause significant morbidity and decrease the quality of life for individuals with Autism Spectrum Disorders (ASD).
- Conditions
- Autism Spectrum Disorder, Developmental Disability, Aggression, Self-Injurious Behavior
- Trial name
- NCT04047355
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Graft-versus-Host-Disease, Leukemia
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults…
- Conditions
- Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer
- Trial name
- NCT04372524
- Where
- 16 sites in United States, Canada
- Volunteers
- 350 people
- Sponsor
- University of British Columbia
Attention Deficit Hyperactivity Disorder
Open-Label, Chronic Exposure, Safety Study of CLONICEL (Clonidine HCl Sustained Release) in Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this 12-month, multi-center, open-label study is to evaluate the safety of CLONICEL (clonidine HCl sustained release) when administered chronically under regular clinical conditions either as monotherapy or in…
- Trial name
- NCT00723190
- Testing
- CLONICEL (Clonidine HCl sustained release)
- Where
- 27 sites in United States
- Volunteers
- 303 people
- Sponsor
- Shionogi
Immune Thrombocytopenia
Hetrombopag for Pediatric Patients With Chronic Immune Thrombocytopenia
The purpose of this study is to investigate the efficacy, safety of Hetrombopag in children with previously treated chronic immune thrombocytopenia who are between 6 and 17 years of age. This is a 2 part study.
- Trial name
- NCT04737850
- Testing
- Hetrombopag
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Cerebral Palsy (CP), Spasticity Due to Cerebral Palsy
Effect of Botulinum Toxin Type A on Motor Function in Children With Cerebral Palsy
Project Identification and Researchers Title: "Changes in functionality and quality of life when applying the botulinum toxin type A infiltration protocol in children and adolescents with cerebral palsy of the spastic hemiparesis…
- Conditions
- Cerebral Palsy (CP), Spasticity Due to Cerebral Palsy, Hemiparesis
- Trial name
- NCT07034547
- Testing
- Botulinum toxin infiltration
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Instituto Teletón Chile
Type 1 Diabetes
Testing MST to Improve Adherence Among Youth With Chronic Poor Metabolic Control
The protocol is a randomized clinical trial providing Multisystemic Therapy (MST), an intensive home-based family psychotherapy intervention, to a group of urban adolescents with poorly controlled Type 1 diabetes and their…
- Trial name
- NCT00519935
- Testing
- Multisystemic Therapy
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Wayne State University
Sickle Cell Disease, Solid Tumor
Validating Pain Scales in Children and Young Adults
Background: Assessing pain levels is important to improve treatments for different illnesses. Most pain rating scales are used to determine pain levels in adults. Pain is also a common symptom among children who have cancer.
- Conditions
- Sickle Cell Disease, Solid Tumor, Leukemia, Neurofibromatosis
- Trial name
- NCT01639950
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- National Cancer Institute (NCI)
Cerebral Palsy, Children
Physical, Functional and Neural Effects of Two Lower Extremity Exercise Protocols in Children With Cerebral Palsy
Background: Many people who have cerebral palsy (CP) have spastic diplegia, which affects the legs and causes difficulty with leg movement and walking.
- Conditions
- Cerebral Palsy, Children, Adolescents
- Trial name
- NCT01086670
- Testing
- Physical Exercise
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Chronic Diseases in Adolescence, Cardio Vascular Disease
Lifestyle Practices With Chronic Diseases Among Different Professionals
A qualitative study conducted in 2018 Exploring socio-cultural factors impacting adherence to type 2 diabetes therapy in rural Sargodha featured respondents who were primarily doctors, patients, and.
- Conditions
- Chronic Diseases in Adolescence, Cardio Vascular Disease, Diabetes Type 2
- Trial name
- NCT05865717
- Testing
- Quantitative sampling, Qualitative interviews
- Where
- Pakistan
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Health Services Academy, Islamabad, Pakistan
Depression in Adolescence, Depressive Disorder
Clinical Effectiveness of TARA Compared to Standard Treatment for Adolescents and Young Adults With Depression
Depressive Disorders constitute an increasing global health concern and available treatments for young people have not been sufficiently effective in haltering this trend.
- Conditions
- Depression in Adolescence, Depressive Disorder, Dysthymia and Chronic Depression
- Trial name
- TARA (NCT04747340)
- Testing
- Training for Awareness Resilience and Action (TARA), Standard treatment
- Where
- 3 sites in Sweden
- Volunteers
- 136 people
- Sponsor
- Umeå University