Clinical trials: Chronic Diseases in Children
Caregivers, Parents
Self-Management in Parents of Technology-Dependent Children
Parent caregivers of children with chronic conditions who require life-saving technology such as mechanical ventilation or feeding tubes must maintain a high level of vigilance 24 hours a day, 7 days a week.
- Conditions
- Caregivers, Parents, Self-Management, Chronic Illnesses, Multiple
- Trial name
- NCT04105244
- Testing
- Resourcefulness Training©
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Hypertension, Chronic Kidney Disease
Safety and Tolerability of Valsartan in Children 6 to 17 Years of Age
The purpose of this study is to assess the long-term safety and tolerability profile of valsartan and valsartan-based treatments in children with hypertension, with or without chronic kidney disease.
- Trial name
- NCT01365481
- Testing
- Valsartan, amlodipine, Hydrochlorothiazide
- Where
- 28 sites in Colombia, Finland and 8 more
- Volunteers
- 150 people
- Sponsor
- Novartis Pharmaceuticals
Cerebral Palsy, Lower Urinary Tract Symptoms
Incontinence and MRI Results in Children with Cerebral Palsy
More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment.
- Trial name
- NCT05060211
- Testing
- Vancouver symptom score for dysfunctional elimination syndroms, Magnetic resonance imaging
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- University Hospital, Ghent
Sinusitis
Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
Healthy children may develop symptoms of chronic sinusitis such as chronic cough, chronic runny nose, nasal congestion, even headaches.
- Trial name
- NCT00465530
- Testing
- Saline, Gentamycin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Julie Wei, MD
Cerebral Palsy
Evaluation of Functional, Neuroplastic and Biomechanical Changes Induced by an Intensive, Playful Early-morning Treatment Including Lower Limbs (EARLY-HABIT-ILE) in Preschool Children With Uni and Bilateral Cerebral Palsy
An urgent priority in the field of paediatric neurorehabilitation is the development of effective early motor interventions. Hand and Arm Bimanual Intensive Therapy Including Lower Extremities (= HABIT-ILE) applies the concepts…
- Trial name
- HABIT-ILE (NCT04017871)
- Testing
- MRI, Electro-Encephalography-High Density (children with unilateral PC only), 3D and EMG analysis
- Where
- 2 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Brest
Cerebral Palsy
Home-based Virtual Reality Rehabilitation for Children With Cerebral Palsy
Rationale: In a way, VR-based gaming shows some similarities to Constraint-induced movement therapy. VR games are controlled unimanually or bimanually.
- Trial name
- NCT06478082
- Testing
- Home-based virtual reality training
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Sint Maartenskliniek
Cerebral Palsy (CP), Balance
The Effect of Kinesiologic Taping on Trunk Control and Balance in Children With Cerebral Palsy
Title: Effects of Kinesiology Taping on Motor Function, Balance, and Spasticity in Children with Hemiplegic and Diplegic Cerebral Palsy: A Four-Week Study Study Type: Interventional (Clinical Trial) Study Design: Single-group…
- Conditions
- Cerebral Palsy (CP), Balance, Kinesiology Taping, Spasticity
- Trial name
- NCT07188961
- Testing
- kinesiologic taping
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Rumeli University
Cerebral Palsy, Autism or Other Neuromotor Behavior Abnormalities Correlation With Anthropometry
Is There Any Correlation Among Neonates Anthropometry and Neuromotor Behaviour
To explore the association among anthropometric parameters and neuromotor behaviour in neonates for early identification and prediction of later neuromotor deficit.
- Trial name
- NCT05361213
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Asir John Samuel
Cerebral Palsy
Utility of Upper-Extremity Plyometrics in Children With Unilateral Cerebral Palsy
This study was set out to evaluate the effect of a 12-week upper extremity plyometric exercise (Plyo-Ex) on muscle strength and upper extremity function in children with hemiparetic cerebral palsy (Hemi-CP).
- Trial name
- NCT06980246
- Testing
- Plyometric Exercise, Standard exercise program
- Where
- Saudi Arabia
- Volunteers
- 58 people
- Sponsor
- Cairo University
Cerebral Palsy
Whole Body Vibration for Children and Young Adults With Moderate Severity of Cerebral Palsy
Osteopenia is common in children with cerebral palsy (CP) due to poor bone growth and muscle disuse and the problem extends to their adulthood.
- Trial name
- NCT03375736
- Testing
- whole body vibration
- Where
- Hong Kong
- Volunteers
- 14 people
- Sponsor
- The Hong Kong Polytechnic University
Cerebral Palsy, Spastic
Nervus Vagus Stimulation and Cerebral Palsy
When the literature is reviewed, it is difficult to find direct research on the effects of auricular vagus nerve stimulation (aVNS) on the autonomic nervous system and spasticity in children with spastic cerebral palsy.
- Trial name
- NCT06880887
- Testing
- nervus vagus stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Istanbul Medipol University Hospital
Hurler Syndrome, Cerebral Palsy
Effects of Growth Hormone in Chronically Ill Children
The specific aims for this study are - 1. To determine the effect of GH on height, height velocity, body weight and lean body mass.
- Conditions
- Hurler Syndrome, Cerebral Palsy, Juvenile Rheumatoid Arthritis, Crohn Disease
- Trial name
- NCT00286689
- Testing
- Growth Hormone, Whole body Protein turnover, DEXA scan
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Cerebral Palsy
The Effects of Virtual Reality on Upper Extremity Function in Hemiplegic Cerebral Palsy
The investigators have planned a research on the effects of virtual reality therapy and home exercise program on hand functions in children with hemiplegic cerebral palsy in Istanbul University Istanbul Faculty of Medicine in the…
- Trial name
- NCT02841319
- Testing
- Virtual Reality Exercises using Hand Tutor
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University
To Determine Efficacy of the Headpod, Cerebral Palsy
Measuring Head Control Change With 2D Video Analysis After Utilization of Headpod in Children With Poor Head Control
Inclusion Criteria: children ages 2 to 14 years with poor head control and non progressive diagnoses. Exclusion criteria: significant change of status i.e. prolonged hospitalization, surgery; inability to tolerate using Headpod.
- Trial name
- headpod (NCT02764775)
- Testing
- Headpod
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Texas Woman's University
Cerebral Palsy
Non-Invasive Measurement of Pulmonary Dysfunction in Children With Cerebral Palsy
This proposal addresses pulmonary dysfunction in severe cerebral palsy by using a novel non-invasive respiratory sensor. The two aims of the project are to 1) provide a screening tool to detect respiratory distress and 2) Find a…
- Trial name
- NCT05791877
- Testing
- pneuRIP
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Nemours Children's Clinic
Cerebral Palsy, Robotics
Can Robot-Assisted Gait Training In Addition To Conventional Rehabilitation Provide Better Outcomes In Children With Cerebral Palsy?
A total of 26 patients who were diagnosed with CP [diplegic, with Gross Motor Function Classification System (GMFCS) level of 2-5] and who regularly participated in a rehabilitation programme were included in the study after…
- Trial name
- NCT04781101
- Testing
- conventional therapy, RoboGait®
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Okan University
Cerebral Palsy, Post-operative Pain
The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial
Cerebral palsy is common. It affects approximately 3 per 1000 children. Hip displacement due to muscle tightness (spasticity) occurs in up to half of the more severely affected children, and many of these children require major…
- Trial name
- POPPIES (NCT01437644)
- Testing
- botulinum toxin intramuscular injection
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Spastic Cerebral Palsy, Physical Therapy Modalities
Effectiveness of Whole-Body Vibration
Cerebral Palsy is the most common cause of severe physical disability in childhood and may present difficulties and limitations that will have an impact on their independence and integration in all social areas.
- Conditions
- Spastic Cerebral Palsy, Physical Therapy Modalities, Vibration; Exposure, Lower Extremity Weakness, Spastic
- Trial name
- WBVibration (NCT06330311)
- Testing
- Physiotherapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Cerebral Palsy
Exoskeleton-assisted Physiotherapy for Children With Mobility Impairments
Non-ambulatory children with cerebral palsy (CP) and similar childhood-onset neuromotor conditions face many challenges to fulsome participation in everyday life.
- Trial name
- NCT05463211
- Testing
- Trexo Plus Pediatric Exoskeleton
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Hepatitis C, Chronic, Hematologic Malignancy
Pharmacokinetics of Ledipasvir/Sofosbuvir in Hepatitis C Virus-Infected Children With Hematological Malignancy
This is a prospective, controlled, open-label, pharmacokinetic study. This study aims at studying the PK of ledipasvir, sofosbuvir, and GS-331007 metabolite in HCV infected children with hematological malignancy.
- Trial name
- NCT03903185
- Testing
- Ledipasvir / Sofosbuvir Oral Product
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
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