Clinical trials: Chronic Fatigue Symptoms
Chronic Myeloid Leukemia
Nuvigil in Treatment of Cancer-Related Fatigue in Chronic Myeloid Leukemia Patients
The goal of this clinical research study is to learn if Nuvigil (armodafinil) can help to control fatigue in patients with CML. The safety of this drug will also be studied.
- Trial name
- NCT01169753
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Obstructive Pulmonary Disease (COPD)
Neuromuscular Fatigue in Chronic Obstructive Pulonary Disease
Fatigue is a prevalent symptom in Chronic Obstructive Pulmonary Disease (COPD) that limits patients in their daily living activities.
- Trial name
- NEUROTIGUE (NCT04028973)
- Testing
- Single then dual task situation, Dual then single task situation
- Where
- 2 sites in France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
ME/CFS, Long COVID
Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome?
Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people…
- Conditions
- ME/CFS, Long COVID, Post- COVID-19 Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
- Trial name
- ME/CFS (NCT07454395)
- Testing
- Swimming, Cycling
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Myeloproliferative Disease, Polycythemia Vera
ENERGIA: Personalized Exercise Program for Fatigue in Patients With Myeloproliferative Neoplasms and Chronic Myeloid Leukemia
This study evaluates whether a personalized, supervised exercise program can improve fatigue and physical function in patients with myeloproliferative neoplasms (MPN) and chronic myeloid leukemia (CML).
- Conditions
- Myeloproliferative Disease, Polycythemia Vera, Thrombocythemia Essential, Myelofibrosis, Primary
- Trial name
- ENERGIA (NCT07518940)
- Testing
- Participants will take part in a 12-week exercise program that includes aerobic and resistance training, tailored to their individual fitness level and clinical condition.
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Carmen Fava
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Systemic Lupus Erythematosus, Fatigue
REACH (Restore Energy, Activity Can Help) Lupus Study
The goal of this clinical trial is to pilot test the REACH peer coaching program for fatigue in people with systemic lupus erythematosus. The main questions it aims to answer are: 1.
- Trial name
- REACH (NCT06479213)
- Testing
- REACH Peer Coaching Program, REACH Mobile Health Application
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Tufts Medical Center
Chronic Fatigue With OSA, Chronic Fatigue Syndrome With OSA
Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing
Chronic fatigue (CF) and chronic fatigue syndrome (CFS) are disabling disorders that may be induced or aggravated by underlying sleep disturbances. The relationship between sleep quality and fatigue is still not fully elucidated.
- Trial name
- NCT01368718
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Hypothyroidism Primary
Study of Chronic Fatigue, Depression, and Anxiety Among Hypothyroid Patients Attending Assuit University Hospitals
Assessment of the prevalence of chronic fatigue, depression, and anxiety among patients with hypothyroidism in Assuit University Hospital.
- Trial name
- NCT06660888
- Testing
- • Fatigue Severity Scale (FFS). • Hamilton Rating Scale for Depression (HRSD-17). • Hamilton Anxiety Rating Scale (HAM-A).
- Where
- Egypt
- Volunteers
- 406 people
- Sponsor
- Assiut University
Chronic Fatigue Syndrome, Idiopathic Chronic Fatigue
Investigator Initiated Clinical Study to Explore the Efficacy and Safety of Human Placenta Hydrolysate in the Chronic Fatigue Patients
GCJBP Laennec Injection contains a variety of cytokines derived from human placenta, amino acids, peptides, nucleobases, and carbohydrates. This product is approved for improving liver function.
- Trial name
- NCT01742013
- Testing
- GCJBP Laennec Inj.
- Where
- 2 sites in South Korea
- Volunteers
- 78 people
- Sponsor
- Ho Cheol Shin, M.D., Ph.D.
End-Stage Kidney Disease (ESKD), Hemodialysis
Effects of Intradialytic Nutrition on Dialysis Adequacy and Fatigue
This randomized, two-period, two-sequence crossover trial aims to evaluate the effects of intradialytic nutrition on dialysis adequacy, intradialytic hemodynamic parameters, and fatigue in adults receiving maintenance…
- Trial name
- NCT07687498
- Testing
- Standardized Intradialytic Nutrition
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Mersin University
Chronic Fatigue Syndrome
ACT for ME/CFS - an Open Case Trial
The goal of this research project is to evaluate if our well-researched behavior medicine treatment model for chronic pain, based on Acceptance and Commitment Therapy, is safe and effective in increasing quality of life and…
- Trial name
- NCT03562325
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Rikard Wicksell
Chronic Heart Failure
Health Behavior-Related Outcomes With Diaphragmatic Breathing Retraining in Heart Failure Patients
The purpose of this study is to provide information on how the practicing of deep breathing ("DBR" - diaphragmatic breathing re-training) may improve the health outcomes and likelihood of heart failure patients to engage in…
- Trial name
- NCT01886391
- Testing
- Diaphragmatic Breathing Retraining
- Sponsor
- University of Nebraska
Neck Pain Musculoskeletal, Work Related Musculoskeletal Disorders
Effects of Aerobic and Combined Exercise on Pain and Fatigue in Workers With Chronic Neck Pain
This randomized controlled trial investigated the acute effects of aerobic exercise (AE) and combined aerobic and cervical-upper extremity resistance exercise (CE) on the pressure pain threshold (PPT), pain perception, and…
- Trial name
- EIH-CNNP (NCT07546838)
- Testing
- Aerobic Exercise, Combined Exercise, Informed Control
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Hacettepe University
Long COVID
The Efficacy and Safety of a Chinese Herbal Medicine for Long COVID Associated Fatigue
This is a randomized, double-blinded, placebo-controlled clinical trial to determine the efficacy and safety of a Chinese herbal medicine (Shenlingcao oral liquid) for treating long COVID associated fatigue.
- Trial name
- NCT05684952
- Testing
- Shenlingcao Oral Liquid
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Hong Kong Baptist University
Anemia, Cancer Fatigue
Ex Vivo-activated Autologous Lymph Node Lymphocytes in Treating Patients With Chronic Lymphocytic Leukemia
This phase II trial studies the side effects of ex vivo-activated autologous lymph node lymphocytes infusion and to see how well they work in treating patients with chronic lymphocytic leukemia.
- Conditions
- Anemia, Cancer Fatigue, Chronic Lymphocytic Leukemia, Fever
- Trial name
- NCT02530515
- Testing
- Ex Vivo-activated Autologous Lymph Node Lymphocytes, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Post-COVID ME/CFS
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main…
- Trial name
- NCT05697640
- Testing
- Vericiguat Oral Tablet
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Fibromyalgia, Chronic Pain
The Effectiveness of Operant Learning Versus Energy Conservation Activity Pacing Treatments in Fibromyalgia
Activity pacing (AP) is a commonly used treatment for people with chronic pain. Many people with pain try to continue their daily activities at the same level as they were able to manage before they had pain.
- Trial name
- NCT01674335
- Testing
- Operant Learning, Energy Conservation
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depressive Symptoms, Anxiety
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
The heightened vulnerability to COVID-19 of African American older adults in Detroit, Michigan and other marginalized communities is linked to systemic racism experienced over the life course.
- Conditions
- Depressive Symptoms, Anxiety, Chronic Pain, Fatigue
- Trial name
- NCT05451589
- Testing
- RESET, Wellness Check Control
- Where
- United States
- Volunteers
- 457 people
- Sponsor
- University of Michigan
End Stage Renal Disease
Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis
The study will test and compare the efficacy of a single essential amino acid valine with a combination of essential amino acids (EAA) supplement on fatigue, frailty, and cognitive function in end-stage kidney disease (ESKD)…
- Trial name
- OASIS (NCT05705414)
- Testing
- Valine, EEA
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Long COVID, Post-COVID Conditions
Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue
Long COVID can cause persistent symptoms such as fatigue, cognitive difficulties commonly described as brain fog, reduced exercise tolerance, and impaired quality of life.
- Conditions
- Long COVID, Post-COVID Conditions, Fatigue, Cognitive Dysfunction
- Trial name
- NEUROSTIM-LC (NCT07709234)
- Testing
- Transcranial Direct Current Stimulation
- Volunteers
- 20 people
- Sponsor
- University of Las Palmas de Gran Canaria