Clinical trials: Chronic Graft-Versus-Host-Disease
Chronic Obstructive Pulmonary Disease Moderate
Manual Therapy in Addition to Pulmonary Rehabilitation in Moderate Chronic Obstructive Pulmonary Disease.
The aim of this study is to investigate the feasibility of administering this combination of interventions (CMT plus PR) to Veterans with moderate COPD within the context of a hospital-based outpatient pulmonary rehabilitation…
- Trial name
- NCT04386590
- Testing
- Manual Therapy Plus Pulmonary Rehabilitation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Canandaigua VA Medical Center
Cerebral Palsy, Spastic, Posture
The Effect of Trunk Control on Respiratory Muscle Strength
Cerebral palsy (CP) can be defined as a group of disorders of movement and posture, causing activity limitation that are attributed to nonprogressive deficits that take place in the immature brain.
- Conditions
- Cerebral Palsy, Spastic, Posture, Respiratory Muscle Strength, Activities of Daily Living
- Trial name
- NCT03209310
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gazi University
Diabetes Mellitus, Type 2
Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus
An AGE-rich diet can induce after 2-6 weeks persistent increases in mediators linked to vascular dysfunction (e.g. TNFα, VCAM-1) in people with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT00446810
- Testing
- Benfotiamine
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ruhr University of Bochum
Vascular Diseases, Kidney Disease
Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD
Risk of cardiovascular diseases (CVD) is significantly elevated in patients with chronic kidney disease (CKD); however, this increased risk is only partially explained by traditional CV risk factors.
- Conditions
- Vascular Diseases, Kidney Disease, Blood Pressure, Oxidative Stress
- Trial name
- NCT04040959
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Colorado, Denver
Rhinosinusitis
Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis
The study should create data for the selection of a clinically relevant endpoint to assess the potential of Buparid/PARI SINUS to postpone sinus surgery in patients with chronic Rhinosinusitis.
- Trial name
- NCT01955980
- Testing
- Budesonide
- Where
- 3 sites in Germany
- Volunteers
- 19 people
- Sponsor
- Pari Pharma GmbH
Complication of Transplanted Liver
Donor Specific HLA Alloantibodies in Liver Transplantation
The aim is to evaluate the impact of donor specific HLA alloantibodies (DSA) on all-cause mortality and re-transplantation, early allograft dysfunction, acute and chronic rejection, fibrosis, vascular, and biliary complications.
- Trial name
- NCT02784080
- Testing
- HLA-alloantibodies exposure
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 858 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Hepatitis C, Hemodialysis
Retreatment of Dialysis Patients With Chronic Hepatitis C With Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin
Chronic hepatitis C virus (HCV) infection is common in dialysis patients. Interferon (IFN)-based treatment for chronic hepatitis C has been the mainstay therapy in immunocompetent patients.
- Trial name
- NCT00491179
- Testing
- Pegylated interferon alfa-2a and ribavirin
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- National Taiwan University Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Neuromuscular Electrical Stimulation as an Adjunct to Exercise Training in Stable Chronic Obstructive Pulmonary Disease (COPD)
Skeletal muscle dysfunction impairs exercise capacity, quality of life and prognosis in chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01658046
- Testing
- Neuromuscular electrical stimulation, Endurance training, Quadriceps strength training
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Hacettepe University
Advanced Chronic Heart Failure
ELEVATE Early LEvosimendan Vs Usual Care in Advanced Chronic hearT failurE
The purpose of this study is to compare in patients with Advanced Chronic Heart Failure the effects of Levosimendan versus diuretic (single 24-hour infusion) applied at the early detection of impending destabilization on…
- Trial name
- ELEVATE (NCT01290146)
- Testing
- Diuretics, Levosimendan
- Where
- 22 sites in Italy
- Volunteers
- 13 people
- Sponsor
- Niguarda Hospital
Pulmonary Disease, Chronic Obstructive
Long-term Safety Study for GSK573719/GW642444 in Japanese
The objective of this study is to evaluate the safety and tolerability of GSK573719/GW642444 Inhalation Powder 125/25 mcg once-daily.
- Trial name
- DB2115362 (NCT01376388)
- Testing
- GSK573719/GW642444 Inhalation Powder
- Where
- 23 sites in Japan
- Volunteers
- 131 people
- Sponsor
- GlaxoSmithKline
Acidosis, Lactic, Chronic Disease
Prevention of Dichloroacetate Toxicity
This is a study to determine the safety of dichloroacetate (DCA) with a low-tyrosine diet given with or without nitisinone (NTBC) in children with chronic lactic acidosis (CLA).
- Trial name
- NCT00031161
- Testing
- Nitisinone (NTBC), Dichloroacetate, Low-tyrosin diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Asthma
Safety, Tolerability and Pharmacokinetics of Inhaled Laninamivir Octanoate TwinCaps® DPI in Adults With Chronic Asthma
This is a single centre, randomized, double-blind, placebo-controlled, single ascending dose study, in which the safety and pharmacokinetics of laninamivir octanoate administered by inhalation via the TwinCaps® DPI will be…
- Trial name
- NCT02022761
- Testing
- Laninamivir octanoate
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Biota Scientific Management Pty Ltd
Chronic Postherniotomy Pain
Predisposing Factors for Chronic Postherniotomy Pain
Chronic pain affects pain in 5-8% of patients more than a year after groin hernia repair. However no prospective study has investigated potential predisposing factors for development of pain, including genetic, psychosocial and…
- Trial name
- NCT00649142
- Testing
- Open sutured mesh repair, Laparoscopic mesh glue fixation
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 455 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Wet AMD
Genetics Study of Wet Age-Related Macular Degeneration (AMD) Non-Responders to Vascular Endothelial Growth Factor (VEGF) Therapy
To obtain a genotypic analysis of patients with chronic exudative age-related macular degeneration noted to have subretinal or intraretinal edema despite continuous monthly Anti-VEGF therapy.
- Trial name
- NCT01310686
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- West Coast Retina Medical Group, Inc.
Cerebral Palsy Infantile, Caregiver
Experiences, Outcomes and Unmet Needs of Caregivers of Children With Cerebral Palsy
Cerebral palsy (CP ) is one of the most prevalent motor disabilities in childhood, significantly impacting both children and their caregivers.
- Trial name
- NCT06912373
- Volunteers
- 30 people
- Sponsor
- Universitat de Lleida
Periodontitis
Photodynamic Therapy Plus Root Debridement in Gum Disease Treatment V2
Gum disease is a common disease, which affects 45% of the UK adult dentate population. It is caused by bacteria in dental plaque, which produces inflammation and a deepening of the natural crevice between the gum and the tooth…
- Trial name
- PDTV2 (NCT03270254)
- Testing
- light activated dye photodynamic therapy (PDT)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Information Dissemination, Evidence-Based Public Health
Disseminating Public Health Evidence to Support State Health Department Prevention of Cancer and Other Chronic Diseases
The purpose of this study is to identify and evaluate dissemination strategies to promote the uptake of evidence-based cancer and other chronic disease prevention among state-level public health practitioners.
- Trial name
- NCT01978054
- Testing
- Dissemination of public health knowledge
- Where
- United States
- Volunteers
- 1,703 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
COPD, Healthy Adult
Shear Wave Elastography of Intercostal Muscles for the Non-invasive Assessment of the Work of BreathinG
Quantifying respiratory effort is a key step in physiological and clinical research on exercise tolerance, mechanisms of fatigability, and ventilatory impairment.
- Trial name
- SWING (NCT07371754)
- Testing
- Intercostal muscle shear wave elastography (SWE) during standardized inspiratory loading
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier du Havre
Congenital Heart Defect, Chronic Pain
Impacting Children's Physical and Mental Health Through Kinesiology Support in Clinical Care
Over the past four decades, it has become clear that childhood physical activity carries with it a myriad of beneficial effects.
- Conditions
- Congenital Heart Defect, Chronic Pain, Concussion Post Syndrome, Cerebral Palsy
- Trial name
- NCT04106154
- Testing
- Kinesiology Support
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Children's Hospital of Eastern Ontario
Pulmonary Disease, Chronic Obstructive
Pharmacovigilance Study to Evaluate Safety of SERETIDE in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Primary objective: Evaluation of the safety of Seretide discus administration in subjects with COPD. Treatment duration: 2 years. Study has 3 phases: Screening phase (visit 1), treatment phase (visits 2-5.
- Trial name
- NCT00662805
- Testing
- Salmeterol/Fluticasone propionate
- Volunteers
- 762 people
- Sponsor
- GlaxoSmithKline
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